Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 244 |
first page | previous page | next page | last page |
| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| TMPRSS11D | ENSG00000153802 | 0.00 | 0.00 | 0 | 0 |
| MARK3 | ENSG00000075413 | 0.20 | 0.44 | 1 | 2 |
| ATP2B3 | ENSG00000067842 | 0.00 | 0.00 | 0 | 0 |
| ADGRG1 | ENSG00000205336 | 0.00 | 0.00 | 0 | 0 |
| MAP3K5 | ENSG00000197442 | 0.00 | 0.28 | 0 | 2 |
| CA3 | ENSG00000164879 | 0.00 | 0.00 | 0 | 0 |
| ABCA3 | ENSG00000167972 | 0.00 | 0.00 | 0 | 0 |
| TDRD12 | ENSG00000173809 | 0.00 | 0.00 | 0 | 0 |
| KCNK1 | ENSG00000135750 | 0.42 | 0.10 | 2 | 1 |
| MAPKAPK3 | ENSG00000114738 | 0.00 | 0.71 | 0 | 4 |
| MYSM1 | ENSG00000162601 | 0.00 | 0.00 | 0 | 0 |
| SMOC2 | ENSG00000112562 | 0.00 | 0.00 | 0 | 0 |
| GRID2 | ENSG00000152208 | 0.00 | 0.00 | 0 | 0 |
| TNNT2 | ENSG00000118194 | 0.00 | 0.00 | 0 | 0 |
| ATXN3 | ENSG00000066427 | 0.00 | 0.31 | 0 | 1 |
| C5 | ENSG00000106804 | 0.00 | 0.00 | 0 | 0 |
| SMPDL3B | ENSG00000130768 | 0.00 | 0.00 | 0 | 0 |
| TPO | ENSG00000115705 | 0.00 | 0.00 | 0 | 0 |
| GPNMB | ENSG00000136235 | 0.00 | 0.00 | 0 | 0 |
| SLC4A10 | ENSG00000144290 | 0.00 | 0.00 | 0 | 0 |
|
Showing page 244 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.