Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| ADGRE5 | ENSG00000123146 | 0.00 | 0.00 | 0 | 0 |
| GPR37L1 | ENSG00000170075 | 0.00 | 0.00 | 0 | 0 |
| PLA2G15 | ENSG00000103066 | 0.31 | 0.47 | 2 | 2 |
| CACNA1H | ENSG00000196557 | 0.00 | 0.00 | 0 | 0 |
| DPT | ENSG00000143196 | 0.00 | 0.00 | 0 | 0 |
| DDR1 | ENSG00000204580 | 0.00 | 0.00 | 0 | 0 |
| SLC24A1 | ENSG00000074621 | 0.00 | 0.00 | 0 | 0 |
| GRIK3 | ENSG00000163873 | 0.00 | 0.00 | 0 | 0 |
| HSD17B6 | ENSG00000025423 | 0.00 | 0.00 | 0 | 0 |
| SLC25A23 | ENSG00000125648 | 0.00 | 0.00 | 0 | 0 |
| CTLA4 | ENSG00000163599 | 0.00 | 0.00 | 0 | 0 |
| SHH | ENSG00000164690 | 0.00 | 0.11 | 0 | 1 |
| CLUL1 | ENSG00000079101 | 0.00 | 0.00 | 0 | 0 |
| AQP3 | ENSG00000165272 | 0.00 | 0.00 | 0 | 0 |
| PRDM8 | ENSG00000152784 | 0.00 | 0.00 | 0 | 0 |
| ERAP2 | ENSG00000164308 | 0.00 | 0.12 | 0 | 1 |
| GRIA3 | ENSG00000125675 | 0.00 | 0.00 | 0 | 0 |
| MAST2 | ENSG00000086015 | 0.00 | 0.00 | 0 | 0 |
| MAT1A | ENSG00000151224 | 0.00 | 0.00 | 0 | 0 |
| TNFSF14 | ENSG00000125735 | 0.00 | 0.00 | 0 | 0 |
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