Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 24 |
first page | previous page | next page | last page |
| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| SPAM1 | ENSG00000106304 | 0.00 | 0.00 | 0 | 0 |
| PCOLCE | ENSG00000106333 | 0.00 | 0.00 | 0 | 0 |
| IMPDH1 | ENSG00000106348 | 0.12 | 0.25 | 1 | 2 |
| SERPINE1 | ENSG00000106366 | 0.00 | 0.00 | 0 | 0 |
| MEST | ENSG00000106484 | 0.13 | 0.00 | 1 | 0 |
| AGR2 | ENSG00000106541 | 0.00 | 0.00 | 0 | 0 |
| PSMA2 | ENSG00000106588 | 0.00 | 0.00 | 0 | 0 |
| EIF4H | ENSG00000106682 | 0.12 | 0.00 | 1 | 0 |
| CNTNAP3 | ENSG00000106714 | 0.00 | 0.24 | 0 | 2 |
| SPIN1 | ENSG00000106723 | 0.00 | 0.15 | 0 | 1 |
| OGN | ENSG00000106809 | 0.00 | 0.00 | 0 | 0 |
| ASPN | ENSG00000106819 | 0.00 | 0.00 | 0 | 0 |
| ECM2 | ENSG00000106823 | 0.00 | 0.00 | 0 | 0 |
| RLN2 | ENSG00000107014 | 0.35 | 0.19 | 2 | 1 |
| RLN1 | ENSG00000107018 | 0.00 | 0.19 | 0 | 1 |
| KDM4C | ENSG00000107077 | 0.17 | 0.36 | 1 | 2 |
| TESK1 | ENSG00000107140 | 1.40 | 0.13 | 5 | 1 |
| CA9 | ENSG00000107159 | 0.52 | 0.00 | 2 | 0 |
| PTGDS | ENSG00000107317 | 0.00 | 0.00 | 0 | 0 |
| CXCL12 | ENSG00000107562 | 0.00 | 0.00 | 0 | 0 |
|
Showing page 24 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.