Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 215 |
first page | previous page | next page | last page |
| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| NTRK3 | ENSG00000140538 | 0.00 | 0.00 | 0 | 0 |
| CFB | ENSG00000243649 | 0.00 | 0.00 | 0 | 0 |
| SGK3 | ENSG00000104205 | 0.61 | 0.00 | 3 | 0 |
| KLHL17 | ENSG00000187961 | 0.00 | 0.82 | 0 | 4 |
| CYB5R4 | ENSG00000065615 | 0.00 | 0.12 | 0 | 1 |
| NISCH | ENSG00000010322 | 0.00 | 0.91 | 0 | 5 |
| CSNK1D | ENSG00000141551 | 0.80 | 0.21 | 4 | 2 |
| SMARCA4 | ENSG00000127616 | 0.00 | 0.00 | 0 | 0 |
| TMPRSS4 | ENSG00000137648 | 0.00 | 0.00 | 0 | 0 |
| DSCAM | ENSG00000171587 | 0.00 | 0.00 | 0 | 0 |
| KLHL15 | ENSG00000174010 | 0.30 | 0.00 | 2 | 0 |
| FREM1 | ENSG00000164946 | 0.00 | 0.00 | 0 | 0 |
| TFPI | ENSG00000003436 | 0.00 | 0.00 | 0 | 0 |
| CD80 | ENSG00000121594 | 0.00 | 0.00 | 0 | 0 |
| STK11 | ENSG00000118046 | 0.00 | 1.45 | 0 | 5 |
| FUCA1 | ENSG00000179163 | 0.00 | 1.81 | 0 | 5 |
| SFRP4 | ENSG00000106483 | 0.00 | 0.00 | 0 | 0 |
| CREBBP | ENSG00000005339 | 0.00 | 0.62 | 0 | 3 |
| CA11 | ENSG00000063180 | 0.00 | 0.56 | 0 | 2 |
| ATP8B2 | ENSG00000143515 | 0.22 | 0.00 | 1 | 0 |
|
Showing page 215 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.