Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 214 |
first page | previous page | next page | last page |
| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| PLCB2 | ENSG00000137841 | 0.00 | 0.18 | 0 | 1 |
| MBTPS2 | ENSG00000012174 | 0.13 | 0.00 | 1 | 0 |
| SLCO4A1 | ENSG00000101187 | 0.11 | 0.00 | 1 | 0 |
| TUBB2A | ENSG00000137267 | 0.00 | 0.14 | 0 | 1 |
| ITGA7 | ENSG00000135424 | 0.00 | 0.00 | 0 | 0 |
| CTSW | ENSG00000172543 | 0.00 | 0.00 | 0 | 0 |
| NOTUM | ENSG00000185269 | 0.00 | 0.00 | 0 | 0 |
| FASLG | ENSG00000117560 | 0.00 | 0.00 | 0 | 0 |
| CELSR2 | ENSG00000143126 | 0.00 | 0.13 | 0 | 1 |
| NAE1 | ENSG00000159593 | 0.00 | 0.14 | 0 | 1 |
| CYP26B1 | ENSG00000003137 | 0.00 | 0.00 | 0 | 0 |
| PAK3 | ENSG00000077264 | 0.00 | 0.00 | 0 | 0 |
| PVR | ENSG00000073008 | 0.24 | 0.45 | 1 | 2 |
| GPRC5C | ENSG00000170412 | 0.21 | 0.00 | 1 | 0 |
| SLC22A23 | ENSG00000137266 | 0.17 | 0.14 | 1 | 1 |
| COL8A2 | ENSG00000171812 | 0.00 | 0.00 | 0 | 0 |
| SERPINF1 | ENSG00000132386 | 0.00 | 0.13 | 0 | 1 |
| UBA6 | ENSG00000033178 | 0.00 | 0.00 | 0 | 0 |
| MAST4 | ENSG00000069020 | 0.00 | 0.18 | 0 | 1 |
| KCNB2 | ENSG00000182674 | 0.00 | 0.00 | 0 | 0 |
|
Showing page 214 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.