Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 210 |
first page | previous page | next page | last page |
| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| SLC37A3 | ENSG00000157800 | 0.34 | 0.14 | 2 | 1 |
| RDH11 | ENSG00000072042 | 0.00 | 0.84 | 0 | 4 |
| CFLAR | ENSG00000003402 | 0.14 | 0.00 | 1 | 0 |
| COL4A3 | ENSG00000169031 | 0.00 | 0.19 | 0 | 1 |
| PHF12 | ENSG00000109118 | 0.29 | 0.00 | 1 | 0 |
| DPEP2 | ENSG00000167261 | 0.00 | 0.00 | 0 | 0 |
| ADORA2B | ENSG00000170425 | 0.00 | 0.12 | 0 | 1 |
| GPLD1 | ENSG00000112293 | 0.00 | 0.00 | 0 | 0 |
| PPAT | ENSG00000128059 | 0.62 | 0.00 | 3 | 0 |
| HTRA4 | ENSG00000169495 | 0.00 | 0.00 | 0 | 0 |
| ZRANB3 | ENSG00000121988 | 0.00 | 0.19 | 0 | 1 |
| AMBP | ENSG00000106927 | 0.00 | 0.00 | 0 | 0 |
| EFNA4 | ENSG00000243364 | 1.54 | 0.00 | 6 | 0 |
| AKR1B10 | ENSG00000198074 | 0.00 | 0.00 | 0 | 0 |
| CACNB1 | ENSG00000067191 | 0.00 | 0.00 | 0 | 0 |
| IL17B | ENSG00000127743 | 0.00 | 0.00 | 0 | 0 |
| RAI1 | ENSG00000108557 | 0.76 | 0.16 | 1 | 1 |
| MAOA | ENSG00000189221 | 0.00 | 0.00 | 0 | 0 |
| ABCA2 | ENSG00000107331 | 0.28 | 0.52 | 2 | 3 |
| NR0B1 | ENSG00000169297 | 0.00 | 0.00 | 0 | 0 |
|
Showing page 210 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.