Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 204 |
first page | previous page | next page | last page |
| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| GPR19 | ENSG00000183150 | 0.00 | 0.00 | 0 | 0 |
| ROR1 | ENSG00000185483 | 0.00 | 0.00 | 0 | 0 |
| ITPKB | ENSG00000143772 | 0.00 | 0.24 | 0 | 1 |
| SLC35F3 | ENSG00000183780 | 0.00 | 0.10 | 0 | 1 |
| PTPRU | ENSG00000060656 | 0.00 | 0.00 | 0 | 0 |
| PTP4A3 | ENSG00000184489 | 0.72 | 0.00 | 2 | 0 |
| CACNA1D | ENSG00000157388 | 0.00 | 0.16 | 0 | 1 |
| SIRPG | ENSG00000089012 | 0.00 | 0.00 | 0 | 0 |
| USP8 | ENSG00000138592 | 0.00 | 0.00 | 0 | 0 |
| SP140L | ENSG00000185404 | 0.00 | 1.20 | 0 | 5 |
| LAMB4 | ENSG00000091128 | 0.00 | 0.00 | 0 | 0 |
| PLCH1 | ENSG00000114805 | 0.00 | 0.00 | 0 | 0 |
| PTN | ENSG00000105894 | 0.11 | 0.00 | 1 | 0 |
| TRIM69 | ENSG00000185880 | 0.00 | 0.16 | 0 | 1 |
| TNFRSF10B | ENSG00000120889 | 0.00 | 1.17 | 0 | 7 |
| GPM6A | ENSG00000150625 | 0.00 | 0.00 | 0 | 0 |
| STK3 | ENSG00000104375 | 0.69 | 0.00 | 3 | 0 |
| PTBP1 | ENSG00000011304 | 0.00 | 0.30 | 0 | 2 |
| TDO2 | ENSG00000151790 | 0.00 | 0.00 | 0 | 0 |
| AKR1B15 | ENSG00000227471 | 0.00 | 0.00 | 0 | 0 |
|
Showing page 204 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.