Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 196 |
first page | previous page | next page | last page |
| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| COL4A1 | ENSG00000187498 | 0.16 | 0.00 | 1 | 0 |
| CD244 | ENSG00000122223 | 0.00 | 0.00 | 0 | 0 |
| GHR | ENSG00000112964 | 0.00 | 0.00 | 0 | 0 |
| ALOX5AP | ENSG00000132965 | 0.00 | 0.00 | 0 | 0 |
| PLA2R1 | ENSG00000153246 | 0.00 | 0.00 | 0 | 0 |
| TDRKH | ENSG00000182134 | 1.86 | 0.00 | 7 | 0 |
| SV2B | ENSG00000185518 | 0.19 | 0.00 | 1 | 0 |
| MUC4 | ENSG00000145113 | 0.19 | 0.00 | 1 | 0 |
| HCN2 | ENSG00000099822 | 0.00 | 0.18 | 0 | 1 |
| SLC5A1 | ENSG00000100170 | 0.00 | 0.00 | 0 | 0 |
| CACNG4 | ENSG00000075461 | 0.00 | 0.00 | 0 | 0 |
| NPM1 | ENSG00000181163 | 0.43 | 0.00 | 2 | 0 |
| WNK3 | ENSG00000196632 | 0.00 | 0.00 | 0 | 0 |
| SSH2 | ENSG00000141298 | 0.00 | 0.00 | 0 | 0 |
| PCSK2 | ENSG00000125851 | 0.00 | 0.00 | 0 | 0 |
| ABCB9 | ENSG00000150967 | 0.00 | 0.16 | 0 | 1 |
| NETO2 | ENSG00000171208 | 0.00 | 0.00 | 0 | 0 |
| ABCC9 | ENSG00000069431 | 0.62 | 0.00 | 1 | 0 |
| CACNA1C | ENSG00000151067 | 0.73 | 0.00 | 2 | 0 |
| DCLK1 | ENSG00000133083 | 0.00 | 0.00 | 0 | 0 |
|
Showing page 196 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.