Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 19 |
first page | previous page | next page | last page |
| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| CHRDL1 | ENSG00000101938 | 0.00 | 0.00 | 0 | 0 |
| SUV39H1 | ENSG00000101945 | 0.00 | 0.00 | 0 | 0 |
| F9 | ENSG00000101981 | 0.00 | 0.00 | 0 | 0 |
| ABCD1 | ENSG00000101986 | 0.66 | 0.00 | 4 | 0 |
| KCND1 | ENSG00000102057 | 0.00 | 0.00 | 0 | 0 |
| OPN1LW | ENSG00000102076 | 0.00 | 0.00 | 0 | 0 |
| FMR1 | ENSG00000102081 | 0.15 | 0.00 | 1 | 0 |
| PIM2 | ENSG00000102096 | 0.49 | 0.00 | 1 | 0 |
| SLC35A2 | ENSG00000102100 | 0.49 | 0.00 | 1 | 0 |
| RS1 | ENSG00000102104 | 0.00 | 0.00 | 0 | 0 |
| PCSK1N | ENSG00000102109 | 0.00 | 0.00 | 0 | 0 |
| SMS | ENSG00000102172 | 0.13 | 0.00 | 1 | 0 |
| GPR50 | ENSG00000102195 | 0.00 | 0.00 | 0 | 0 |
| JADE3 | ENSG00000102221 | 0.00 | 0.00 | 0 | 0 |
| CDK16 | ENSG00000102225 | 0.14 | 0.00 | 1 | 0 |
| CD40LG | ENSG00000102245 | 0.00 | 0.00 | 0 | 0 |
| TIMP1 | ENSG00000102265 | 0.00 | 0.00 | 0 | 0 |
| GABRE | ENSG00000102287 | 0.00 | 0.00 | 0 | 0 |
| PORCN | ENSG00000102312 | 0.00 | 0.00 | 0 | 0 |
| ITIH6 | ENSG00000102313 | 0.00 | 0.00 | 0 | 0 |
|
Showing page 19 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.