Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 176 |
first page | previous page | next page | last page |
| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| TNFRSF11A | ENSG00000141655 | 0.00 | 0.33 | 0 | 3 |
| HSPG2 | ENSG00000142798 | 0.00 | 0.23 | 0 | 2 |
| COL11A1 | ENSG00000060718 | 0.00 | 0.00 | 0 | 0 |
| CHST11 | ENSG00000171310 | 0.00 | 0.00 | 0 | 0 |
| NSD1 | ENSG00000165671 | 0.34 | 0.11 | 1 | 1 |
| IL6ST | ENSG00000134352 | 0.00 | 0.24 | 0 | 1 |
| DNMT1 | ENSG00000130816 | 0.00 | 0.00 | 0 | 0 |
| ACACB | ENSG00000076555 | 0.00 | 0.00 | 0 | 0 |
| LMTK3 | ENSG00000142235 | 0.00 | 0.33 | 0 | 1 |
| CDH3 | ENSG00000062038 | 0.17 | 0.35 | 1 | 1 |
| PSMA3 | ENSG00000100567 | 0.00 | 0.00 | 0 | 0 |
| LPAR1 | ENSG00000198121 | 0.00 | 0.00 | 0 | 0 |
| PPIL4 | ENSG00000131013 | 0.00 | 0.47 | 0 | 3 |
| SLC1A5 | ENSG00000105281 | 0.00 | 0.33 | 0 | 1 |
| MTAP | ENSG00000099810 | 0.00 | 2.90 | 0 | 4 |
| ITGB1 | ENSG00000150093 | 0.13 | 0.00 | 1 | 0 |
| PPP1CA | ENSG00000172531 | 0.50 | 0.00 | 2 | 0 |
| CACNA2D3 | ENSG00000157445 | 0.00 | 0.00 | 0 | 0 |
| ATP5A1 | ENSG00000152234 | 0.00 | 0.00 | 0 | 0 |
| FN1 | ENSG00000115414 | 0.00 | 0.19 | 0 | 1 |
|
Showing page 176 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.