Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 175 |
first page | previous page | next page | last page |
| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| PTK2 | ENSG00000169398 | 0.91 | 0.00 | 3 | 0 |
| SCD | ENSG00000099194 | 0.00 | 0.00 | 0 | 0 |
| DCLK2 | ENSG00000170390 | 0.00 | 0.00 | 0 | 0 |
| FDPS | ENSG00000160752 | 1.46 | 0.00 | 6 | 0 |
| ENPP3 | ENSG00000154269 | 0.00 | 0.00 | 0 | 0 |
| ERN1 | ENSG00000178607 | 0.66 | 0.00 | 3 | 0 |
| ABCA5 | ENSG00000154265 | 0.64 | 0.00 | 3 | 0 |
| CRTAC1 | ENSG00000095713 | 0.00 | 0.33 | 0 | 1 |
| FARS2 | ENSG00000145982 | 0.67 | 0.43 | 3 | 2 |
| ELP3 | ENSG00000134014 | 0.00 | 0.28 | 0 | 2 |
| AQP7 | ENSG00000165269 | 0.00 | 0.00 | 0 | 0 |
| CDK7 | ENSG00000134058 | 0.00 | 1.10 | 0 | 3 |
| KMT2A | ENSG00000118058 | 0.00 | 0.81 | 0 | 4 |
| MTOR | ENSG00000198793 | 0.00 | 0.85 | 0 | 4 |
| COL7A1 | ENSG00000114270 | 0.00 | 0.51 | 0 | 3 |
| CLK2 | ENSG00000176444 | 1.52 | 0.00 | 6 | 0 |
| ATP6V0A4 | ENSG00000105929 | 0.00 | 0.00 | 0 | 0 |
| DUSP15 | ENSG00000149599 | 0.67 | 0.00 | 3 | 0 |
| SLC45A2 | ENSG00000164175 | 0.00 | 0.00 | 0 | 0 |
| PDCD1LG2 | ENSG00000197646 | 0.86 | 0.00 | 4 | 0 |
|
Showing page 175 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.