Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 174 |
first page | previous page | next page | last page |
| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| BIRC3 | ENSG00000023445 | 1.55 | 0.00 | 4 | 0 |
| IMMP2L | ENSG00000184903 | 0.00 | 1.17 | 0 | 5 |
| LATS2 | ENSG00000150457 | 0.00 | 0.78 | 0 | 4 |
| PPIL2 | ENSG00000100023 | 0.58 | 0.00 | 2 | 0 |
| HSPD1 | ENSG00000144381 | 0.16 | 0.00 | 1 | 0 |
| COL10A1 | ENSG00000123500 | 0.00 | 0.00 | 0 | 0 |
| ATP6V0D2 | ENSG00000147614 | 0.25 | 0.00 | 1 | 0 |
| P4HB | ENSG00000185624 | 0.77 | 0.00 | 4 | 0 |
| KDM2A | ENSG00000173120 | 0.52 | 0.00 | 2 | 0 |
| RPS6KA1 | ENSG00000117676 | 0.00 | 2.72 | 0 | 9 |
| AR | ENSG00000169083 | 0.00 | 0.00 | 0 | 0 |
| TRPM8 | ENSG00000144481 | 0.00 | 0.00 | 0 | 0 |
| BRD4 | ENSG00000141867 | 2.08 | 0.00 | 6 | 0 |
| MDM4 | ENSG00000198625 | 1.08 | 0.00 | 3 | 0 |
| LRP8 | ENSG00000157193 | 0.00 | 0.00 | 0 | 0 |
| SLAMF1 | ENSG00000117090 | 0.00 | 0.00 | 0 | 0 |
| PRDM1 | ENSG00000057657 | 0.00 | 0.12 | 0 | 1 |
| MFSD12 | ENSG00000161091 | 0.13 | 1.20 | 1 | 3 |
| NR3C1 | ENSG00000113580 | 0.31 | 0.15 | 1 | 1 |
| SETDB2 | ENSG00000136169 | 0.00 | 0.35 | 0 | 2 |
|
Showing page 174 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.