Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 173 |
first page | previous page | next page | last page |
| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| PI4KA | ENSG00000241973 | 0.58 | 0.00 | 2 | 0 |
| PIK3C3 | ENSG00000078142 | 0.00 | 0.00 | 0 | 0 |
| CAMK4 | ENSG00000152495 | 0.00 | 0.14 | 0 | 1 |
| THBS2 | ENSG00000186340 | 0.00 | 0.00 | 0 | 0 |
| ATP6V1A | ENSG00000114573 | 0.00 | 0.00 | 0 | 0 |
| BLM | ENSG00000197299 | 0.73 | 0.00 | 4 | 0 |
| SLC39A6 | ENSG00000141424 | 0.00 | 0.00 | 0 | 0 |
| SETD2 | ENSG00000181555 | 0.00 | 0.71 | 0 | 4 |
| SMYD3 | ENSG00000185420 | 0.90 | 0.25 | 4 | 1 |
| SLC44A4 | ENSG00000204385 | 0.00 | 0.00 | 0 | 0 |
| F12 | ENSG00000131187 | 0.00 | 0.11 | 0 | 1 |
| SRM | ENSG00000116649 | 0.11 | 0.64 | 1 | 3 |
| CHD7 | ENSG00000171316 | 0.36 | 0.00 | 2 | 0 |
| PDK1 | ENSG00000152256 | 0.00 | 0.00 | 0 | 0 |
| TP53 | ENSG00000141510 | 0.00 | 1.12 | 0 | 3 |
| PLD1 | ENSG00000075651 | 1.15 | 0.00 | 3 | 0 |
| EPCAM | ENSG00000119888 | 0.13 | 0.00 | 1 | 0 |
| FAT1 | ENSG00000083857 | 0.00 | 1.49 | 0 | 7 |
| NEGR1 | ENSG00000172260 | 0.00 | 0.00 | 0 | 0 |
| CD3G | ENSG00000160654 | 0.00 | 0.23 | 0 | 1 |
|
Showing page 173 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.