Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| SRD5A2 | ENSG00000277893 | 0.00 | 0.00 | 0 | 0 |
| OR52E5 | ENSG00000277932 | 0.00 | 0.00 | 0 | 0 |
| DHRS11 | ENSG00000278535 | 0.00 | 0.00 | 0 | 0 |
| OR4F29 | ENSG00000278566 | 0.00 | 0.00 | 0 | 0 |
| NR2E3 | ENSG00000278570 | 0.00 | 0.00 | 0 | 0 |
| HIST1H4B | ENSG00000278705 | 0.00 | 0.00 | 0 | 0 |
| HIST1H3H | ENSG00000278828 | 0.00 | 0.00 | 0 | 0 |
| OR51G1 | ENSG00000278870 | 0.00 | 0.00 | 0 | 0 |
| OR2S2 | ENSG00000278889 | 0.00 | 0.00 | 0 | 0 |
| OR10A6 | ENSG00000279000 | 0.00 | 0.00 | 0 | 0 |
| OR51B2 | ENSG00000279012 | 0.00 | 0.00 | 0 | 0 |
| OR6Q1 | ENSG00000279051 | 0.00 | 0.00 | 0 | 0 |
| OR10X1 | ENSG00000279111 | 0.00 | 0.00 | 0 | 0 |
| OR8D2 | ENSG00000279116 | 0.00 | 0.00 | 0 | 0 |
| OR52R1 | ENSG00000279270 | 0.00 | 0.00 | 0 | 0 |
| OR2T11 | ENSG00000279301 | 0.00 | 0.00 | 0 | 0 |
| OR5L1 | ENSG00000279395 | 0.00 | 0.00 | 0 | 0 |
| OR2AG1 | ENSG00000279486 | 0.00 | 0.00 | 0 | 0 |
| OR4C16 | ENSG00000279514 | 0.00 | 0.00 | 0 | 0 |
| OR5R1 | ENSG00000279961 | 0.00 | 0.00 | 0 | 0 |
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