Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| HIST1H3A | ENSG00000275714 | 0.00 | 0.00 | 0 | 0 |
| LYZL6 | ENSG00000275722 | 0.00 | 0.00 | 0 | 0 |
| PRSS2 | ENSG00000275896 | 0.00 | 0.00 | 0 | 0 |
| DUSP14 | ENSG00000276023 | 0.00 | 0.00 | 0 | 0 |
| UHRF1 | ENSG00000276043 | 0.00 | 0.00 | 0 | 0 |
| CCL4L2 | ENSG00000276070 | 0.00 | 0.00 | 0 | 0 |
| CCL3L3 | ENSG00000276085 | 0.00 | 0.00 | 0 | 0 |
| OR13C2 | ENSG00000276119 | 0.00 | 0.00 | 0 | 0 |
| HIST1H4I | ENSG00000276180 | 0.00 | 0.00 | 0 | 0 |
| PIK3R6 | ENSG00000276231 | 0.00 | 0.00 | 0 | 0 |
| OR4E1 | ENSG00000276240 | 0.00 | 0.00 | 0 | 0 |
| CCL14 | ENSG00000276409 | 0.00 | 0.00 | 0 | 0 |
| HIST1H4E | ENSG00000276966 | 0.00 | 0.00 | 0 | 0 |
| HIST1H4D | ENSG00000277157 | 0.00 | 0.00 | 0 | 0 |
| GPR179 | ENSG00000277399 | 0.00 | 0.00 | 0 | 0 |
| PKD1L3 | ENSG00000277481 | 0.00 | 0.00 | 0 | 0 |
| GPIHBP1 | ENSG00000277494 | 0.00 | 0.00 | 0 | 0 |
| OR13C5 | ENSG00000277556 | 0.00 | 0.00 | 0 | 0 |
| CCL3 | ENSG00000277632 | 0.00 | 0.00 | 0 | 0 |
| PSMB3 | ENSG00000277791 | 0.00 | 0.11 | 0 | 1 |
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