Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| OR4C45 | ENSG00000260811 | 0.00 | 0.00 | 0 | 0 |
| SULT1A3 | ENSG00000261052 | 0.17 | 0.00 | 1 | 0 |
| TUBB8 | ENSG00000261456 | 0.00 | 0.00 | 0 | 0 |
| HPR | ENSG00000261701 | 0.00 | 0.00 | 0 | 0 |
| MIA | ENSG00000261857 | 0.00 | 0.00 | 0 | 0 |
| OR1P1 | ENSG00000262085 | 0.00 | 0.00 | 0 | 0 |
| MMP12 | ENSG00000262406 | 0.00 | 0.00 | 0 | 0 |
| OR1D5 | ENSG00000262628 | 0.00 | 0.00 | 0 | 0 |
| OR52L2P | ENSG00000262980 | 0.00 | 0.00 | 0 | 0 |
| PPIAL4C | ENSG00000263464 | 0.00 | 0.00 | 0 | 0 |
| GDF2 | ENSG00000263761 | 0.00 | 0.00 | 0 | 0 |
| AKR1C8P | ENSG00000264006 | 0.00 | 0.00 | 0 | 0 |
| RBP3 | ENSG00000265203 | 0.00 | 0.00 | 0 | 0 |
| BAHCC1 | ENSG00000266074 | 0.00 | 0.00 | 0 | 0 |
| PNLIPRP2 | ENSG00000266200 | 0.00 | 0.00 | 0 | 0 |
| GDF10 | ENSG00000266524 | 0.00 | 0.00 | 0 | 0 |
| LCN6 | ENSG00000267206 | 0.00 | 0.00 | 0 | 0 |
| GABRQ | ENSG00000268089 | 0.00 | 0.00 | 0 | 0 |
| SLC6A14 | ENSG00000268104 | 0.00 | 0.00 | 0 | 0 |
| OPN1MW | ENSG00000268221 | 0.00 | 0.00 | 0 | 0 |
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