Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| MTRNR2L1 | ENSG00000256618 | 0.00 | 0.00 | 0 | 0 |
| PGA5 | ENSG00000256713 | 0.00 | 0.00 | 0 | 0 |
| MTRNR2L7 | ENSG00000256892 | 0.00 | 0.00 | 0 | 0 |
| GPR142 | ENSG00000257008 | 0.00 | 0.00 | 0 | 0 |
| OR11H12 | ENSG00000257115 | 0.00 | 0.00 | 0 | 0 |
| TAS2R38 | ENSG00000257138 | 0.00 | 0.00 | 0 | 0 |
| MGAM2 | ENSG00000257743 | 0.00 | 0.00 | 0 | 0 |
| OR9A4 | ENSG00000258083 | 0.00 | 0.00 | 0 | 0 |
| PRSS58 | ENSG00000258223 | 0.00 | 0.00 | 0 | 0 |
| RP11-371E8.2 | ENSG00000258595 | 0.00 | 0.00 | 0 | 0 |
| SERPINA2 | ENSG00000258597 | 0.00 | 0.00 | 0 | 0 |
| BCL2L2-PABPN1 | ENSG00000258643 | 0.00 | 0.00 | 0 | 0 |
| OR11H7 | ENSG00000258806 | 0.00 | 0.00 | 0 | 0 |
| OR4C13 | ENSG00000258817 | 0.00 | 0.00 | 0 | 0 |
| RNASE4 | ENSG00000258818 | 0.00 | 0.00 | 0 | 0 |
| MC1R | ENSG00000258839 | 0.00 | 0.33 | 0 | 3 |
| ITGB3 | ENSG00000259207 | 0.00 | 0.00 | 0 | 0 |
| GH1 | ENSG00000259384 | 0.00 | 0.00 | 0 | 0 |
| SLC22A31 | ENSG00000259803 | 0.00 | 0.00 | 0 | 0 |
| MRC1 | ENSG00000260314 | 0.00 | 0.00 | 0 | 0 |
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