Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| IGLL5 | ENSG00000254709 | 0.00 | 0.00 | 0 | 0 |
| OR10G4 | ENSG00000254737 | 0.00 | 0.00 | 0 | 0 |
| OR5M10 | ENSG00000254834 | 0.00 | 0.00 | 0 | 0 |
| OR5M1 | ENSG00000255012 | 0.00 | 0.00 | 0 | 0 |
| OR1D4 | ENSG00000255095 | 0.00 | 0.00 | 0 | 0 |
| OR5M11 | ENSG00000255223 | 0.00 | 0.00 | 0 | 0 |
| OR52B2 | ENSG00000255307 | 0.00 | 0.00 | 0 | 0 |
| TAS2R43 | ENSG00000255374 | 0.00 | 0.00 | 0 | 0 |
| HCAR3 | ENSG00000255398 | 0.00 | 0.00 | 0 | 0 |
| OR10G2 | ENSG00000255582 | 0.00 | 0.00 | 0 | 0 |
| OR4D2 | ENSG00000255713 | 0.00 | 0.00 | 0 | 0 |
| OR6J1 | ENSG00000255804 | 0.00 | 0.00 | 0 | 0 |
| MTRNR2L8 | ENSG00000255823 | 0.00 | 0.00 | 0 | 0 |
| TAS2R20 | ENSG00000255837 | 0.55 | 0.00 | 1 | 0 |
| CTSO | ENSG00000256043 | 0.00 | 0.00 | 0 | 0 |
| MTRNR2L10 | ENSG00000256045 | 0.00 | 0.00 | 0 | 0 |
| TAS2R30 | ENSG00000256188 | 0.00 | 0.00 | 0 | 0 |
| MTRNR2L3 | ENSG00000256222 | 0.00 | 0.00 | 0 | 0 |
| ASIC5 | ENSG00000256394 | 0.00 | 0.00 | 0 | 0 |
| TAS2R31 | ENSG00000256436 | 0.55 | 0.00 | 1 | 0 |
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