Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| OR1F12 | ENSG00000220721 | 0.00 | 0.00 | 0 | 0 |
| OR6B1 | ENSG00000221813 | 0.00 | 0.00 | 0 | 0 |
| OR2A5 | ENSG00000221836 | 0.00 | 0.00 | 0 | 0 |
| OR4A5 | ENSG00000221840 | 0.00 | 0.00 | 0 | 0 |
| TAS2R41 | ENSG00000221855 | 0.00 | 0.00 | 0 | 0 |
| OR2A12 | ENSG00000221858 | 0.00 | 0.00 | 0 | 0 |
| OR3A2 | ENSG00000221882 | 0.00 | 0.00 | 0 | 0 |
| HMSD | ENSG00000221887 | 0.00 | 0.12 | 0 | 1 |
| OR1C1 | ENSG00000221888 | 0.00 | 0.00 | 0 | 0 |
| OR2F2 | ENSG00000221910 | 0.00 | 0.00 | 0 | 0 |
| TRIM16 | ENSG00000221926 | 0.67 | 0.31 | 1 | 2 |
| OR6X1 | ENSG00000221931 | 0.00 | 0.00 | 0 | 0 |
| OR2A25 | ENSG00000221933 | 0.00 | 0.00 | 0 | 0 |
| TAS2R40 | ENSG00000221937 | 0.00 | 0.00 | 0 | 0 |
| OR2A14 | ENSG00000221938 | 0.00 | 0.00 | 0 | 0 |
| OR4C12 | ENSG00000221954 | 0.00 | 0.00 | 0 | 0 |
| KIR2DS4 | ENSG00000221957 | 0.00 | 0.00 | 0 | 0 |
| OR4E2 | ENSG00000221977 | 0.00 | 0.00 | 0 | 0 |
| OR2A2 | ENSG00000221989 | 0.00 | 0.00 | 0 | 0 |
| OR52B4 | ENSG00000221996 | 0.00 | 0.00 | 0 | 0 |
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