Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| SLC22A20 | ENSG00000197847 | 0.00 | 0.00 | 0 | 0 |
| OR8G1 | ENSG00000197849 | 0.00 | 0.00 | 0 | 0 |
| OR1S2 | ENSG00000197887 | 0.00 | 0.00 | 0 | 0 |
| UGT2B17 | ENSG00000197888 | 0.00 | 0.00 | 0 | 0 |
| SLC22A12 | ENSG00000197891 | 0.00 | 0.00 | 0 | 0 |
| ADH5 | ENSG00000197894 | 0.00 | 0.10 | 0 | 1 |
| SLC22A6 | ENSG00000197901 | 0.00 | 0.00 | 0 | 0 |
| IFNA1 | ENSG00000197919 | 0.00 | 0.00 | 0 | 0 |
| ERO1L | ENSG00000197930 | 0.00 | 0.00 | 0 | 0 |
| OR5H2 | ENSG00000197938 | 0.00 | 0.00 | 0 | 0 |
| AADACL2 | ENSG00000197953 | 0.00 | 0.00 | 0 | 0 |
| TUBA3C | ENSG00000198033 | 0.00 | 0.00 | 0 | 0 |
| AVPR1B | ENSG00000198049 | 0.00 | 0.00 | 0 | 0 |
| SIRPA | ENSG00000198053 | 0.00 | 0.00 | 0 | 0 |
| PRIM1 | ENSG00000198056 | 0.00 | 0.00 | 0 | 0 |
| TMPRSS11F | ENSG00000198092 | 0.00 | 0.00 | 0 | 0 |
| ADH4 | ENSG00000198099 | 0.00 | 0.10 | 0 | 1 |
| OR2T6 | ENSG00000198104 | 0.00 | 0.00 | 0 | 0 |
| OR2L3 | ENSG00000198128 | 0.00 | 0.00 | 0 | 0 |
| CLEC4C | ENSG00000198178 | 0.00 | 0.00 | 0 | 0 |
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