Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| OR6Y1 | ENSG00000197532 | 0.00 | 0.00 | 0 | 0 |
| GZMM | ENSG00000197540 | 0.00 | 0.00 | 0 | 0 |
| ELANE | ENSG00000197561 | 0.00 | 0.00 | 0 | 0 |
| COL4A6 | ENSG00000197565 | 0.00 | 0.00 | 0 | 0 |
| OR11L1 | ENSG00000197591 | 0.00 | 0.00 | 0 | 0 |
| ENPP1 | ENSG00000197594 | 0.00 | 0.46 | 0 | 4 |
| MFAP5 | ENSG00000197614 | 0.00 | 0.00 | 0 | 0 |
| SERPINB2 | ENSG00000197632 | 0.00 | 0.12 | 0 | 1 |
| SERPINB13 | ENSG00000197641 | 0.00 | 0.00 | 0 | 0 |
| SLC22A24 | ENSG00000197658 | 0.00 | 0.00 | 0 | 0 |
| OR51C1P | ENSG00000197674 | 0.00 | 0.00 | 0 | 0 |
| NMB | ENSG00000197696 | 0.32 | 0.00 | 2 | 0 |
| OR6C74 | ENSG00000197706 | 0.00 | 0.00 | 0 | 0 |
| SCGB1D4 | ENSG00000197745 | 0.00 | 0.00 | 0 | 0 |
| TXNRD3 | ENSG00000197763 | 0.00 | 0.00 | 0 | 0 |
| CFD | ENSG00000197766 | 0.00 | 0.16 | 0 | 1 |
| OR5B17 | ENSG00000197786 | 0.00 | 0.00 | 0 | 0 |
| OR52M1 | ENSG00000197790 | 0.00 | 0.00 | 0 | 0 |
| HIST4H4 | ENSG00000197837 | 0.00 | 0.00 | 0 | 0 |
| CYP2A13 | ENSG00000197838 | 0.00 | 0.00 | 0 | 0 |
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