Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| PLA2G2C | ENSG00000187980 | 0.00 | 0.00 | 0 | 0 |
| C17orf99 | ENSG00000187997 | 0.22 | 0.00 | 1 | 0 |
| OR7D2 | ENSG00000188000 | 0.00 | 0.00 | 0 | 0 |
| CTSL3P | ENSG00000188029 | 0.00 | 0.00 | 0 | 0 |
| CLCN1 | ENSG00000188037 | 0.00 | 0.00 | 0 | 0 |
| WNT7B | ENSG00000188064 | 0.00 | 0.00 | 0 | 0 |
| SCGB1C1 | ENSG00000188076 | 0.00 | 0.00 | 0 | 0 |
| PRSS45 | ENSG00000188086 | 0.00 | 0.00 | 0 | 0 |
| OR2AG2 | ENSG00000188124 | 0.00 | 0.00 | 0 | 0 |
| OTOG | ENSG00000188162 | 0.00 | 0.00 | 0 | 0 |
| TUBB4B | ENSG00000188229 | 0.39 | 0.38 | 2 | 2 |
| PLA2G2A | ENSG00000188257 | 0.00 | 0.22 | 0 | 1 |
| OR7A5 | ENSG00000188269 | 0.00 | 0.00 | 0 | 0 |
| IGFL1 | ENSG00000188293 | 0.00 | 0.31 | 0 | 1 |
| SBK1 | ENSG00000188322 | 0.00 | 0.00 | 0 | 0 |
| OR6C6 | ENSG00000188324 | 0.00 | 0.00 | 0 | 0 |
| BSPH1 | ENSG00000188334 | 0.00 | 0.00 | 0 | 0 |
| SLC38A3 | ENSG00000188338 | 0.00 | 0.18 | 0 | 1 |
| OR6N2 | ENSG00000188340 | 0.00 | 0.00 | 0 | 0 |
| ZP3 | ENSG00000188372 | 0.00 | 0.00 | 0 | 0 |
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