Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| KCNJ11 | ENSG00000187486 | 0.00 | 0.00 | 0 | 0 |
| ATP13A5 | ENSG00000187527 | 0.00 | 0.00 | 0 | 0 |
| SBK2 | ENSG00000187550 | 0.00 | 0.00 | 0 | 0 |
| CYP26C1 | ENSG00000187553 | 0.00 | 0.00 | 0 | 0 |
| ISG15 | ENSG00000187608 | 0.00 | 0.82 | 0 | 4 |
| OR5W2 | ENSG00000187612 | 0.00 | 0.00 | 0 | 0 |
| HAPLN4 | ENSG00000187664 | 0.00 | 0.00 | 0 | 0 |
| TRPV2 | ENSG00000187688 | 0.00 | 0.00 | 0 | 0 |
| AMTN | ENSG00000187689 | 0.00 | 0.00 | 0 | 0 |
| OR2T27 | ENSG00000187701 | 0.00 | 0.00 | 0 | 0 |
| SLC18A3 | ENSG00000187714 | 0.00 | 0.00 | 0 | 0 |
| KBTBD12 | ENSG00000187715 | 0.00 | 0.00 | 0 | 0 |
| AMY1C | ENSG00000187733 | 0.00 | 0.11 | 0 | 1 |
| OR52B6 | ENSG00000187747 | 0.00 | 0.00 | 0 | 0 |
| ADH1A | ENSG00000187758 | 0.00 | 0.00 | 0 | 0 |
| TMEM256-PLSCR3 | ENSG00000187838 | 0.00 | 0.15 | 0 | 1 |
| P2RX2 | ENSG00000187848 | 0.00 | 0.00 | 0 | 0 |
| OR6C75 | ENSG00000187857 | 0.00 | 0.00 | 0 | 0 |
| OR51I2 | ENSG00000187918 | 0.00 | 0.00 | 0 | 0 |
| OVCH1 | ENSG00000187950 | 0.00 | 0.00 | 0 | 0 |
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