Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| OR10D4P | ENSG00000186268 | 0.00 | 0.00 | 0 | 0 |
| KDM4D | ENSG00000186280 | 0.00 | 0.16 | 0 | 1 |
| OR10T2 | ENSG00000186306 | 0.00 | 0.00 | 0 | 0 |
| SLC36A2 | ENSG00000186335 | 0.00 | 0.00 | 0 | 0 |
| CYP4X1 | ENSG00000186377 | 0.00 | 0.00 | 0 | 0 |
| FCAR | ENSG00000186431 | 0.00 | 0.00 | 0 | 0 |
| OR6P1 | ENSG00000186440 | 0.00 | 0.00 | 0 | 0 |
| KLK12 | ENSG00000186474 | 0.00 | 0.00 | 0 | 0 |
| OR9Q1 | ENSG00000186509 | 0.00 | 0.00 | 0 | 0 |
| CLCNKA | ENSG00000186510 | 0.00 | 0.00 | 0 | 0 |
| OR9Q2 | ENSG00000186513 | 0.00 | 0.00 | 0 | 0 |
| CYP4F8 | ENSG00000186526 | 0.00 | 0.00 | 0 | 0 |
| PRG2 | ENSG00000186652 | 0.00 | 0.00 | 0 | 0 |
| CYP27C1 | ENSG00000186684 | 0.00 | 0.00 | 0 | 0 |
| MST1L | ENSG00000186715 | 0.00 | 0.32 | 0 | 2 |
| OR10H1 | ENSG00000186723 | 0.00 | 0.00 | 0 | 0 |
| SPIN4 | ENSG00000186767 | 0.00 | 0.00 | 0 | 0 |
| SPIN2B | ENSG00000186787 | 0.00 | 0.00 | 0 | 0 |
| KCNK18 | ENSG00000186795 | 0.00 | 0.00 | 0 | 0 |
| IFNA10 | ENSG00000186803 | 0.00 | 0.00 | 0 | 0 |
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