Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| ATP6V0C | ENSG00000185883 | 0.00 | 0.00 | 0 | 0 |
| IFITM1 | ENSG00000185885 | 0.00 | 0.30 | 0 | 2 |
| PRSS38 | ENSG00000185888 | 0.00 | 0.00 | 0 | 0 |
| FFAR3 | ENSG00000185897 | 0.00 | 0.00 | 0 | 0 |
| TAS2R60 | ENSG00000185899 | 0.00 | 0.00 | 0 | 0 |
| POMK | ENSG00000185900 | 0.00 | 0.00 | 0 | 0 |
| RTN4RL1 | ENSG00000185924 | 0.00 | 0.13 | 0 | 1 |
| OR4C46 | ENSG00000185926 | 0.00 | 0.00 | 0 | 0 |
| GRK1 | ENSG00000185974 | 0.00 | 0.00 | 0 | 0 |
| HTR3E | ENSG00000186038 | 0.00 | 0.00 | 0 | 0 |
| CD300LF | ENSG00000186074 | 0.00 | 0.00 | 0 | 0 |
| OR4F5 | ENSG00000186092 | 0.00 | 0.00 | 0 | 0 |
| AGBL4 | ENSG00000186094 | 0.00 | 0.00 | 0 | 0 |
| OR5D14 | ENSG00000186113 | 0.00 | 0.00 | 0 | 0 |
| OR5D18 | ENSG00000186119 | 0.00 | 0.00 | 0 | 0 |
| TAS2R42 | ENSG00000186136 | 0.00 | 0.00 | 0 | 0 |
| FFAR4 | ENSG00000186188 | 0.00 | 0.00 | 0 | 0 |
| BPIFB3 | ENSG00000186190 | 0.00 | 0.00 | 0 | 0 |
| BPIFB4 | ENSG00000186191 | 0.00 | 0.00 | 0 | 0 |
| BTLA | ENSG00000186265 | 0.00 | 0.00 | 0 | 0 |
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