Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| FAM19A3 | ENSG00000184599 | 0.00 | 0.00 | 0 | 0 |
| OR51M1 | ENSG00000184698 | 0.00 | 0.00 | 0 | 0 |
| LRRC26 | ENSG00000184709 | 0.17 | 0.21 | 1 | 1 |
| RNLS | ENSG00000184719 | 0.00 | 0.31 | 0 | 1 |
| APOO | ENSG00000184831 | 0.30 | 0.00 | 2 | 0 |
| TMED9 | ENSG00000184840 | 0.34 | 0.11 | 1 | 1 |
| DRD1 | ENSG00000184845 | 0.00 | 0.00 | 0 | 0 |
| SDR42E1 | ENSG00000184860 | 0.00 | 0.00 | 0 | 0 |
| CLCNKB | ENSG00000184908 | 0.00 | 0.00 | 0 | 0 |
| OR6A2 | ENSG00000184933 | 0.00 | 0.00 | 0 | 0 |
| OR6C70 | ENSG00000184954 | 0.00 | 0.00 | 0 | 0 |
| MUC6 | ENSG00000184956 | 0.00 | 0.00 | 0 | 0 |
| CHRM5 | ENSG00000184984 | 0.00 | 0.00 | 0 | 0 |
| SLC22A10 | ENSG00000184999 | 0.00 | 0.00 | 0 | 0 |
| DGAT1 | ENSG00000185000 | 0.88 | 0.00 | 3 | 0 |
| CA13 | ENSG00000185015 | 0.16 | 0.00 | 1 | 0 |
| FLRT2 | ENSG00000185070 | 0.00 | 0.10 | 0 | 1 |
| C6orf120 | ENSG00000185127 | 0.00 | 1.06 | 0 | 4 |
| INPP5J | ENSG00000185133 | 0.22 | 0.00 | 1 | 0 |
| NPY2R | ENSG00000185149 | 0.00 | 0.00 | 0 | 0 |
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