Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| OR5T2 | ENSG00000181718 | 0.00 | 0.00 | 0 | 0 |
| OR2Z1 | ENSG00000181733 | 0.00 | 0.00 | 0 | 0 |
| OR8K5 | ENSG00000181752 | 0.00 | 0.00 | 0 | 0 |
| OR8H3 | ENSG00000181761 | 0.00 | 0.00 | 0 | 0 |
| OR8H2 | ENSG00000181767 | 0.00 | 0.00 | 0 | 0 |
| GPR3 | ENSG00000181773 | 0.00 | 0.00 | 0 | 0 |
| OR5AS1 | ENSG00000181785 | 0.00 | 0.00 | 0 | 0 |
| OR6S1 | ENSG00000181803 | 0.00 | 0.00 | 0 | 0 |
| SLC35C1 | ENSG00000181830 | 0.17 | 0.00 | 1 | 0 |
| SLC2A4 | ENSG00000181856 | 0.00 | 0.00 | 0 | 0 |
| OR4C6 | ENSG00000181903 | 0.00 | 0.00 | 0 | 0 |
| OR4P4 | ENSG00000181927 | 0.00 | 0.00 | 0 | 0 |
| PRKAG1 | ENSG00000181929 | 0.00 | 0.00 | 0 | 0 |
| OR4C15 | ENSG00000181939 | 0.00 | 0.00 | 0 | 0 |
| OR4A15 | ENSG00000181958 | 0.00 | 0.00 | 0 | 0 |
| OR4A16 | ENSG00000181961 | 0.00 | 0.00 | 0 | 0 |
| OR52K2 | ENSG00000181963 | 0.00 | 0.00 | 0 | 0 |
| OR52A1 | ENSG00000182070 | 0.00 | 0.00 | 0 | 0 |
| OR6B2 | ENSG00000182083 | 0.00 | 0.00 | 0 | 0 |
| TNRC18 | ENSG00000182095 | 0.46 | 0.41 | 3 | 1 |
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