Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| SLC25A41 | ENSG00000181240 | 0.00 | 0.00 | 0 | 0 |
| OR5AK2 | ENSG00000181273 | 0.00 | 0.00 | 0 | 0 |
| OR5AK3P | ENSG00000181282 | 0.00 | 0.00 | 0 | 0 |
| HEPHL1 | ENSG00000181333 | 0.00 | 0.00 | 0 | 0 |
| OR5M8 | ENSG00000181371 | 0.00 | 0.00 | 0 | 0 |
| CCL13 | ENSG00000181374 | 0.00 | 0.00 | 0 | 0 |
| UTS2R | ENSG00000181408 | 0.00 | 0.00 | 0 | 0 |
| AATK | ENSG00000181409 | 0.62 | 0.00 | 3 | 0 |
| OR6T1 | ENSG00000181499 | 0.00 | 0.00 | 0 | 0 |
| OR8D4 | ENSG00000181518 | 0.00 | 0.00 | 0 | 0 |
| SGSH | ENSG00000181523 | 1.26 | 0.00 | 5 | 0 |
| EDDM3A | ENSG00000181562 | 0.00 | 0.00 | 0 | 0 |
| OR52D1 | ENSG00000181609 | 0.00 | 0.00 | 0 | 0 |
| OR52H1 | ENSG00000181616 | 0.00 | 0.00 | 0 | 0 |
| FDCSP | ENSG00000181617 | 0.00 | 0.00 | 0 | 0 |
| GPR135 | ENSG00000181619 | 0.00 | 0.23 | 0 | 1 |
| TNFSF15 | ENSG00000181634 | 0.00 | 0.00 | 0 | 0 |
| GPR88 | ENSG00000181656 | 0.00 | 0.00 | 0 | 0 |
| OR8H1 | ENSG00000181693 | 0.00 | 0.00 | 0 | 0 |
| OR5T1 | ENSG00000181698 | 0.00 | 0.00 | 0 | 0 |
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