Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| ADGRD2 | ENSG00000180264 | 0.00 | 0.00 | 0 | 0 |
| GPR139 | ENSG00000180269 | 0.00 | 0.00 | 0 | 0 |
| FZD2 | ENSG00000180340 | 0.00 | 0.18 | 0 | 1 |
| CYP8B1 | ENSG00000180432 | 0.00 | 0.00 | 0 | 0 |
| OR6K6 | ENSG00000180433 | 0.00 | 0.00 | 0 | 0 |
| OR6K4P | ENSG00000180437 | 0.00 | 0.00 | 0 | 0 |
| OR10Q1 | ENSG00000180475 | 0.00 | 0.00 | 0 | 0 |
| KCNE1 | ENSG00000180509 | 0.00 | 0.00 | 0 | 0 |
| SSTR2 | ENSG00000180616 | 0.00 | 0.00 | 0 | 0 |
| PRF1 | ENSG00000180644 | 0.00 | 0.00 | 0 | 0 |
| OR2A4 | ENSG00000180658 | 0.00 | 0.00 | 0 | 0 |
| YOD1 | ENSG00000180667 | 0.12 | 0.00 | 1 | 0 |
| OR10K2 | ENSG00000180708 | 0.00 | 0.00 | 0 | 0 |
| CHRM4 | ENSG00000180720 | 0.00 | 0.00 | 0 | 0 |
| SHISA2 | ENSG00000180730 | 0.00 | 0.00 | 0 | 0 |
| CHST13 | ENSG00000180767 | 0.00 | 0.00 | 0 | 0 |
| AGTR2 | ENSG00000180772 | 0.00 | 0.00 | 0 | 0 |
| SLC36A4 | ENSG00000180773 | 0.14 | 0.00 | 1 | 0 |
| OR51E1 | ENSG00000180785 | 0.00 | 0.00 | 0 | 0 |
| ARSJ | ENSG00000180801 | 0.00 | 0.00 | 0 | 0 |
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