Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| OR51G2 | ENSG00000176893 | 0.00 | 0.00 | 0 | 0 |
| OR51A7 | ENSG00000176895 | 0.00 | 0.00 | 0 | 0 |
| OR51T1 | ENSG00000176900 | 0.00 | 0.00 | 0 | 0 |
| OR51H1 | ENSG00000176904 | 0.00 | 0.00 | 0 | 0 |
| C8G | ENSG00000176919 | 0.00 | 0.23 | 0 | 1 |
| OR51S1 | ENSG00000176922 | 0.00 | 0.00 | 0 | 0 |
| OR51F2 | ENSG00000176925 | 0.00 | 0.00 | 0 | 0 |
| FIBIN | ENSG00000176971 | 0.00 | 0.00 | 0 | 0 |
| IFNW1 | ENSG00000177047 | 0.00 | 0.00 | 0 | 0 |
| OR2T35 | ENSG00000177151 | 0.00 | 0.00 | 0 | 0 |
| OR14C36 | ENSG00000177174 | 0.00 | 0.00 | 0 | 0 |
| OR2M7 | ENSG00000177186 | 0.00 | 0.00 | 0 | 0 |
| OR2T12 | ENSG00000177201 | 0.00 | 0.00 | 0 | 0 |
| OR2T33 | ENSG00000177212 | 0.00 | 0.00 | 0 | 0 |
| TRIM72 | ENSG00000177238 | 0.00 | 0.00 | 0 | 0 |
| MAN1B1 | ENSG00000177239 | 0.17 | 0.52 | 1 | 3 |
| DEFB103B | ENSG00000177243 | 0.00 | 0.00 | 0 | 0 |
| KCNA3 | ENSG00000177272 | 0.00 | 0.00 | 0 | 0 |
| OR2AJ1 | ENSG00000177275 | 0.00 | 0.00 | 0 | 0 |
| FZD8 | ENSG00000177283 | 0.00 | 0.00 | 0 | 0 |
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