Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| OR4M1 | ENSG00000176299 | 0.00 | 0.00 | 0 | 0 |
| OR4H12P | ENSG00000176312 | 0.00 | 0.00 | 0 | 0 |
| TAC4 | ENSG00000176358 | 0.00 | 0.00 | 0 | 0 |
| RNPEP | ENSG00000176393 | 0.00 | 0.00 | 0 | 0 |
| CLEC14A | ENSG00000176435 | 0.00 | 0.00 | 0 | 0 |
| OR5AN1 | ENSG00000176495 | 0.00 | 0.00 | 0 | 0 |
| OR10AC1 | ENSG00000176510 | 0.00 | 0.00 | 0 | 0 |
| OR4C5 | ENSG00000176540 | 0.00 | 0.00 | 0 | 0 |
| OR4C3 | ENSG00000176547 | 0.00 | 0.00 | 0 | 0 |
| OR4S1 | ENSG00000176555 | 0.00 | 0.00 | 0 | 0 |
| OR4X1 | ENSG00000176567 | 0.00 | 0.00 | 0 | 0 |
| KBTBD11 | ENSG00000176595 | 0.00 | 0.48 | 0 | 3 |
| OR4F17 | ENSG00000176695 | 0.00 | 0.00 | 0 | 0 |
| OR51V1 | ENSG00000176742 | 0.00 | 0.00 | 0 | 0 |
| OR52Z1 | ENSG00000176748 | 0.00 | 0.00 | 0 | 0 |
| CDK5R1 | ENSG00000176749 | 0.00 | 0.00 | 0 | 0 |
| DEFB104A | ENSG00000176782 | 0.00 | 0.00 | 0 | 0 |
| OR52E2 | ENSG00000176787 | 0.00 | 0.00 | 0 | 0 |
| DEFB103A | ENSG00000176797 | 0.00 | 0.00 | 0 | 0 |
| OR51L1 | ENSG00000176798 | 0.00 | 0.00 | 0 | 0 |
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