Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| SFN | ENSG00000175793 | 0.00 | 0.41 | 0 | 2 |
| CALCB | ENSG00000175868 | 0.00 | 0.00 | 0 | 0 |
| CREG2 | ENSG00000175874 | 0.00 | 0.00 | 0 | 0 |
| KLHL38 | ENSG00000175946 | 0.69 | 0.00 | 2 | 0 |
| TMPRSS7 | ENSG00000176040 | 0.00 | 0.00 | 0 | 0 |
| MC5R | ENSG00000176136 | 0.00 | 0.00 | 0 | 0 |
| GPX2 | ENSG00000176153 | 0.00 | 0.00 | 0 | 0 |
| SPHK1 | ENSG00000176170 | 0.00 | 0.00 | 0 | 0 |
| OR11H4 | ENSG00000176198 | 0.00 | 0.00 | 0 | 0 |
| OR4D11 | ENSG00000176200 | 0.00 | 0.00 | 0 | 0 |
| OR11H6 | ENSG00000176219 | 0.00 | 0.00 | 0 | 0 |
| OR4K17 | ENSG00000176230 | 0.00 | 0.00 | 0 | 0 |
| OR10H4 | ENSG00000176231 | 0.00 | 0.00 | 0 | 0 |
| OR51B6 | ENSG00000176239 | 0.00 | 0.00 | 0 | 0 |
| OR4L1 | ENSG00000176246 | 0.00 | 0.00 | 0 | 0 |
| OR4K13 | ENSG00000176253 | 0.00 | 0.00 | 0 | 0 |
| OR4F21 | ENSG00000176269 | 0.00 | 0.00 | 0 | 0 |
| SLC35G1 | ENSG00000176273 | 0.00 | 0.45 | 0 | 2 |
| OR4K5 | ENSG00000176281 | 0.00 | 0.00 | 0 | 0 |
| OR4N2 | ENSG00000176294 | 0.00 | 0.00 | 0 | 0 |
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