Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| CD34 | ENSG00000174059 | 0.00 | 0.00 | 0 | 0 |
| TLR10 | ENSG00000174123 | 0.00 | 0.00 | 0 | 0 |
| TLR1 | ENSG00000174125 | 0.00 | 0.00 | 0 | 0 |
| TLR6 | ENSG00000174130 | 0.00 | 0.00 | 0 | 0 |
| GSTA3 | ENSG00000174156 | 0.00 | 0.00 | 0 | 0 |
| SELP | ENSG00000174175 | 0.00 | 0.00 | 0 | 0 |
| SLC16A11 | ENSG00000174326 | 0.00 | 0.15 | 0 | 1 |
| OR2Y1 | ENSG00000174339 | 0.00 | 0.00 | 0 | 0 |
| PODN | ENSG00000174348 | 0.00 | 0.00 | 0 | 0 |
| TRHR | ENSG00000174417 | 0.00 | 0.00 | 0 | 0 |
| KLK15 | ENSG00000174562 | 0.00 | 0.00 | 0 | 0 |
| IL20RB | ENSG00000174564 | 0.00 | 0.00 | 0 | 0 |
| OR7D4 | ENSG00000174667 | 0.00 | 0.00 | 0 | 0 |
| BRSK2 | ENSG00000174672 | 0.00 | 0.12 | 0 | 1 |
| LEP | ENSG00000174697 | 0.00 | 0.00 | 0 | 0 |
| FGFBP3 | ENSG00000174721 | 0.00 | 0.31 | 0 | 1 |
| CD248 | ENSG00000174807 | 0.00 | 0.00 | 0 | 0 |
| BTC | ENSG00000174808 | 0.00 | 0.00 | 0 | 0 |
| AMY1B | ENSG00000174876 | 0.00 | 0.00 | 0 | 0 |
| OR9G1 | ENSG00000174914 | 0.00 | 0.00 | 0 | 0 |
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