Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| TP53RK | ENSG00000172315 | 0.15 | 0.00 | 1 | 0 |
| OR5A1 | ENSG00000172320 | 0.00 | 0.00 | 0 | 0 |
| OR5A2 | ENSG00000172324 | 0.00 | 0.00 | 0 | 0 |
| IL16 | ENSG00000172349 | 0.00 | 0.00 | 0 | 0 |
| ABCG4 | ENSG00000172350 | 0.00 | 0.00 | 0 | 0 |
| CDY1B | ENSG00000172352 | 0.00 | 0.00 | 0 | 0 |
| OR5B12 | ENSG00000172362 | 0.00 | 0.00 | 0 | 0 |
| OR5B2 | ENSG00000172365 | 0.00 | 0.00 | 0 | 0 |
| OR9I1 | ENSG00000172377 | 0.00 | 0.00 | 0 | 0 |
| PRSS27 | ENSG00000172382 | 0.00 | 0.00 | 0 | 0 |
| INSL5 | ENSG00000172410 | 0.00 | 0.00 | 0 | 0 |
| OR9G4 | ENSG00000172457 | 0.00 | 0.00 | 0 | 0 |
| IL17D | ENSG00000172458 | 0.00 | 0.16 | 0 | 1 |
| OR5AR1 | ENSG00000172459 | 0.00 | 0.00 | 0 | 0 |
| PRSS30P | ENSG00000172460 | 0.00 | 0.00 | 0 | 0 |
| OR5AP2 | ENSG00000172464 | 0.00 | 0.00 | 0 | 0 |
| OR8J1 | ENSG00000172487 | 0.00 | 0.00 | 0 | 0 |
| OR5T3 | ENSG00000172489 | 0.00 | 0.00 | 0 | 0 |
| OR10H5 | ENSG00000172519 | 0.00 | 0.00 | 0 | 0 |
| MUCL1 | ENSG00000172551 | 0.00 | 0.00 | 0 | 0 |
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