Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| OR52A5 | ENSG00000171944 | 0.00 | 0.00 | 0 | 0 |
| CYP4F22 | ENSG00000171954 | 0.00 | 0.00 | 0 | 0 |
| PPIH | ENSG00000171960 | 0.12 | 0.00 | 1 | 0 |
| REG1B | ENSG00000172023 | 0.00 | 0.00 | 0 | 0 |
| LAMB2 | ENSG00000172037 | 0.00 | 0.53 | 0 | 3 |
| SMN1 | ENSG00000172062 | 0.00 | 1.13 | 0 | 3 |
| SLC9C1 | ENSG00000172139 | 0.00 | 0.00 | 0 | 0 |
| OR1A1 | ENSG00000172146 | 0.00 | 0.00 | 0 | 0 |
| AC005255.6 | ENSG00000172148 | 0.00 | 0.00 | 0 | 0 |
| OR1A2 | ENSG00000172150 | 0.00 | 0.00 | 0 | 0 |
| OR8I2 | ENSG00000172154 | 0.00 | 0.00 | 0 | 0 |
| CCL11 | ENSG00000172156 | 0.00 | 0.00 | 0 | 0 |
| OR4C11 | ENSG00000172188 | 0.00 | 0.00 | 0 | 0 |
| OR8U1 | ENSG00000172199 | 0.00 | 0.00 | 0 | 0 |
| OR4X2 | ENSG00000172208 | 0.00 | 0.00 | 0 | 0 |
| GPR22 | ENSG00000172209 | 0.00 | 0.00 | 0 | 0 |
| CXCR6 | ENSG00000172215 | 0.00 | 0.00 | 0 | 0 |
| TPSAB1 | ENSG00000172236 | 0.00 | 0.00 | 0 | 0 |
| CDY1 | ENSG00000172288 | 0.00 | 0.00 | 0 | 0 |
| OR10V1 | ENSG00000172289 | 0.00 | 0.00 | 0 | 0 |
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