Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| FABP5 | ENSG00000164687 | 0.01 | 0.00 | 0.01 | 0.00 | 0.06 | 0.00 | 0.09 | 0.01 | 0.16 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.01 | 0.14 | 0.03 | 0.05 | 0.00 | 0.13 | 0.01 | 0.12 | 0.01 | 0.11 | 0.00 | 0.17 | 0.01 | 0.01 | 0.01 | 0.12 | 0.00 | 0.19 | 0.01 | 0.06 | 0.00 | 0.03 | 0.01 | 0.00 | 0.00 | 0.27 | 0.01 | 0.27 | 0.10 | 0.04 | 0.01 | 0.05 | 0.01 | 0.15 | 0.02 | 0.18 | 0.05 | 0.14 | 0.00 | 0.00 | 0.00 | 0.08 | 0.00 | 0.01 | 0.01 | 0.01 | 0.01 | 0.22 | 0.00 | 0.13 | 0.01 |
| SLC13A4 | ENSG00000164707 | 0.01 | 0.01 | 0.07 | 0.00 | 0.04 | 0.00 | 0.03 | 0.03 | 0.04 | 0.04 | 0.00 | 0.01 | 0.04 | 0.05 | 0.07 | 0.02 | 0.08 | 0.06 | 0.02 | 0.14 | 0.04 | 0.19 | 0.02 | 0.07 | 0.03 | 0.00 | 0.07 | 0.01 | 0.01 | 0.04 | 0.04 | 0.04 | 0.00 | 0.02 | 0.03 | 0.06 | 0.00 | 0.01 | 0.00 | 0.00 | 0.09 | 0.03 | 0.46 | 0.04 | 0.03 | 0.08 | 0.05 | 0.05 | 0.05 | 0.16 | 0.15 | 0.06 | 0.02 | 0.04 | 0.00 | 0.05 | 0.02 | 0.09 | 0.11 | 0.00 | 0.05 | 0.01 | 0.00 | 0.00 | 0.19 | 0.02 |
| HNF4G | ENSG00000164749 | 0.01 | 0.00 | 0.01 | 0.00 | 0.08 | 0.00 | 0.05 | 0.02 | 0.14 | 0.02 | 0.00 | 0.00 | 0.00 | 0.01 | 0.18 | 0.02 | 0.10 | 0.03 | 0.05 | 0.01 | 0.12 | 0.00 | 0.14 | 0.00 | 0.07 | 0.00 | 0.14 | 0.01 | 0.01 | 0.01 | 0.07 | 0.00 | 0.05 | 0.01 | 0.08 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.19 | 0.02 | 0.29 | 0.07 | 0.02 | 0.01 | 0.06 | 0.01 | 0.15 | 0.02 | 0.17 | 0.04 | 0.19 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.01 | 0.01 | 0.22 | 0.00 | 0.07 | 0.01 |
| KCNV1 | ENSG00000164794 | 0.01 | 0.00 | 0.01 | 0.00 | 0.20 | 0.00 | 0.08 | 0.02 | 0.24 | 0.02 | 0.02 | 0.00 | 0.02 | 0.03 | 0.16 | 0.02 | 0.27 | 0.01 | 0.19 | 0.00 | 0.38 | 0.00 | 0.18 | 0.01 | 0.14 | 0.00 | 0.17 | 0.01 | 0.06 | 0.01 | 0.34 | 0.01 | 0.25 | 0.01 | 0.04 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.45 | 0.01 | 0.97 | 0.04 | 0.14 | 0.00 | 0.12 | 0.01 | 0.31 | 0.00 | 0.12 | 0.05 | 0.05 | 0.01 | 0.00 | 0.00 | 0.08 | 0.00 | 0.17 | 0.00 | 0.01 | 0.02 | 0.43 | 0.00 | 0.14 | 0.01 |
| DEFA5 | ENSG00000164816 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.12 | 0.01 | 0.15 | 0.00 | 0.00 | 0.02 | 0.04 | 0.03 | 0.07 | 0.01 | 0.14 | 0.00 | 0.08 | 0.16 | 0.08 | 0.17 | 0.04 | 0.01 | 0.10 | 0.00 | 0.20 | 0.03 | 0.05 | 0.01 | 0.14 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.16 | 0.04 | 0.42 | 0.01 | 0.05 | 0.00 | 0.09 | 0.03 | 0.28 | 0.05 | 0.13 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.08 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.01 | 0.02 | 0.03 |
| DEFA4 | ENSG00000164821 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.09 | 0.01 | 0.14 | 0.00 | 0.00 | 0.02 | 0.04 | 0.03 | 0.07 | 0.01 | 0.13 | 0.00 | 0.08 | 0.18 | 0.07 | 0.17 | 0.03 | 0.01 | 0.09 | 0.00 | 0.19 | 0.03 | 0.04 | 0.01 | 0.13 | 0.00 | 0.01 | 0.00 | 0.05 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.16 | 0.05 | 0.38 | 0.01 | 0.06 | 0.00 | 0.09 | 0.03 | 0.28 | 0.06 | 0.13 | 0.01 | 0.01 | 0.00 | 0.00 | 0.04 | 0.06 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.01 | 0.02 | 0.03 |
| DEFA6 | ENSG00000164822 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.09 | 0.01 | 0.14 | 0.00 | 0.00 | 0.02 | 0.04 | 0.03 | 0.07 | 0.01 | 0.13 | 0.00 | 0.08 | 0.18 | 0.07 | 0.19 | 0.03 | 0.01 | 0.09 | 0.00 | 0.19 | 0.03 | 0.04 | 0.01 | 0.13 | 0.00 | 0.01 | 0.00 | 0.05 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.16 | 0.05 | 0.38 | 0.01 | 0.06 | 0.00 | 0.09 | 0.03 | 0.28 | 0.05 | 0.13 | 0.01 | 0.01 | 0.00 | 0.00 | 0.04 | 0.06 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.01 | 0.02 | 0.03 |
| DEFB1 | ENSG00000164825 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.10 | 0.02 | 0.13 | 0.00 | 0.00 | 0.02 | 0.06 | 0.03 | 0.07 | 0.01 | 0.13 | 0.00 | 0.08 | 0.18 | 0.07 | 0.17 | 0.03 | 0.01 | 0.09 | 0.00 | 0.19 | 0.03 | 0.04 | 0.01 | 0.13 | 0.00 | 0.01 | 0.00 | 0.05 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.16 | 0.05 | 0.38 | 0.01 | 0.06 | 0.00 | 0.09 | 0.03 | 0.28 | 0.05 | 0.14 | 0.01 | 0.01 | 0.00 | 0.00 | 0.04 | 0.06 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.01 | 0.02 | 0.03 |
| GPER1 | ENSG00000164850 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.03 | 0.14 | 0.04 | 0.00 | 0.00 | 0.10 | 0.00 | 0.11 | 0.01 | 0.14 | 0.04 | 0.13 | 0.02 | 0.25 | 0.04 | 0.15 | 0.03 | 0.05 | 0.01 | 0.04 | 0.01 | 0.05 | 0.00 | 0.06 | 0.02 | 0.01 | 0.01 | 0.16 | 0.03 | 0.00 | 0.01 | 0.00 | 0.00 | 0.08 | 0.07 | 0.14 | 0.40 | 0.05 | 0.02 | 0.04 | 0.07 | 0.28 | 0.05 | 0.13 | 0.06 | 0.15 | 0.01 | 0.00 | 0.01 | 0.15 | 0.00 | 0.01 | 0.04 | 0.05 | 0.01 | 0.00 | 0.00 | 0.15 | 0.01 |
| SPAG11B | ENSG00000164871 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.12 | 0.01 | 0.15 | 0.00 | 0.00 | 0.02 | 0.04 | 0.03 | 0.07 | 0.01 | 0.14 | 0.00 | 0.08 | 0.16 | 0.08 | 0.17 | 0.04 | 0.01 | 0.10 | 0.00 | 0.20 | 0.03 | 0.05 | 0.01 | 0.14 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.16 | 0.04 | 0.42 | 0.01 | 0.05 | 0.00 | 0.09 | 0.03 | 0.28 | 0.05 | 0.13 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.08 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.01 | 0.02 | 0.03 |
| CDK5 | ENSG00000164885 | 0.03 | 0.01 | 0.04 | 0.00 | 0.09 | 0.00 | 0.03 | 0.03 | 0.05 | 0.05 | 0.00 | 0.01 | 0.00 | 0.03 | 0.10 | 0.02 | 0.10 | 0.09 | 0.02 | 0.17 | 0.04 | 0.25 | 0.03 | 0.10 | 0.02 | 0.01 | 0.01 | 0.02 | 0.02 | 0.05 | 0.07 | 0.04 | 0.00 | 0.11 | 0.07 | 0.07 | 0.00 | 0.03 | 0.00 | 0.00 | 0.07 | 0.07 | 0.53 | 0.08 | 0.04 | 0.09 | 0.03 | 0.06 | 0.08 | 0.19 | 0.10 | 0.15 | 0.01 | 0.05 | 0.00 | 0.06 | 0.02 | 0.09 | 0.10 | 0.01 | 0.07 | 0.01 | 0.00 | 0.03 | 0.20 | 0.03 |
| SLC4A2 | ENSG00000164889 | 0.03 | 0.01 | 0.04 | 0.00 | 0.09 | 0.00 | 0.03 | 0.03 | 0.05 | 0.05 | 0.00 | 0.01 | 0.00 | 0.03 | 0.10 | 0.02 | 0.10 | 0.09 | 0.02 | 0.17 | 0.04 | 0.24 | 0.03 | 0.10 | 0.02 | 0.01 | 0.01 | 0.02 | 0.02 | 0.05 | 0.07 | 0.04 | 0.00 | 0.11 | 0.07 | 0.07 | 0.00 | 0.03 | 0.00 | 0.00 | 0.07 | 0.07 | 0.54 | 0.08 | 0.04 | 0.09 | 0.03 | 0.06 | 0.08 | 0.19 | 0.10 | 0.13 | 0.01 | 0.05 | 0.00 | 0.06 | 0.02 | 0.09 | 0.10 | 0.01 | 0.07 | 0.01 | 0.00 | 0.03 | 0.20 | 0.03 |
| SLC7A13 | ENSG00000164893 | 0.00 | 0.00 | 0.00 | 0.01 | 0.06 | 0.00 | 0.06 | 0.02 | 0.15 | 0.01 | 0.00 | 0.00 | 0.02 | 0.00 | 0.15 | 0.01 | 0.13 | 0.03 | 0.06 | 0.01 | 0.16 | 0.00 | 0.13 | 0.00 | 0.10 | 0.00 | 0.12 | 0.02 | 0.02 | 0.01 | 0.15 | 0.00 | 0.20 | 0.01 | 0.06 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.28 | 0.01 | 0.30 | 0.10 | 0.06 | 0.01 | 0.04 | 0.01 | 0.23 | 0.04 | 0.18 | 0.06 | 0.16 | 0.00 | 0.00 | 0.00 | 0.04 | 0.02 | 0.03 | 0.00 | 0.01 | 0.01 | 0.25 | 0.00 | 0.09 | 0.01 |
| FZD6 | ENSG00000164930 | 0.01 | 0.00 | 0.01 | 0.00 | 0.21 | 0.00 | 0.07 | 0.01 | 0.49 | 0.01 | 0.02 | 0.00 | 0.02 | 0.01 | 0.20 | 0.01 | 0.24 | 0.02 | 0.17 | 0.01 | 0.35 | 0.00 | 0.25 | 0.00 | 0.12 | 0.01 | 0.19 | 0.00 | 0.05 | 0.01 | 0.31 | 0.00 | 0.25 | 0.01 | 0.04 | 0.00 | 0.00 | 0.03 | 0.00 | 0.00 | 0.48 | 0.00 | 0.73 | 0.08 | 0.13 | 0.00 | 0.11 | 0.01 | 0.44 | 0.00 | 0.14 | 0.06 | 0.08 | 0.00 | 0.00 | 0.00 | 0.08 | 0.02 | 0.13 | 0.00 | 0.01 | 0.01 | 0.42 | 0.00 | 0.14 | 0.01 |
| CTHRC1 | ENSG00000164932 | 0.01 | 0.00 | 0.01 | 0.00 | 0.21 | 0.00 | 0.08 | 0.01 | 0.47 | 0.01 | 0.02 | 0.00 | 0.02 | 0.01 | 0.19 | 0.01 | 0.24 | 0.01 | 0.17 | 0.00 | 0.35 | 0.00 | 0.25 | 0.00 | 0.12 | 0.01 | 0.19 | 0.00 | 0.05 | 0.01 | 0.31 | 0.00 | 0.25 | 0.01 | 0.04 | 0.00 | 0.00 | 0.03 | 0.00 | 0.00 | 0.48 | 0.00 | 0.74 | 0.07 | 0.15 | 0.00 | 0.11 | 0.01 | 0.44 | 0.00 | 0.14 | 0.06 | 0.08 | 0.00 | 0.00 | 0.00 | 0.08 | 0.02 | 0.13 | 0.00 | 0.01 | 0.00 | 0.42 | 0.00 | 0.14 | 0.01 |
| KIAA1161 | ENSG00000164976 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.02 | 0.07 | 0.04 | 0.00 | 0.00 | 0.01 | 0.11 | 0.06 | 0.02 | 0.37 | 0.04 | 0.21 | 0.03 | 0.28 | 0.03 | 0.18 | 0.02 | 0.01 | 0.00 | 0.01 | 0.00 | 0.05 | 0.01 | 0.05 | 0.01 | 0.24 | 0.05 | 0.06 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.07 | 0.02 | 0.11 | 0.06 | 0.01 | 0.01 | 0.06 | 0.02 | 0.09 | 0.05 | 0.12 | 0.06 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.05 | 0.07 | 0.00 | 0.03 | 0.05 | 0.05 |
| PRKACG | ENSG00000165059 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.03 | 0.05 | 0.01 | 0.01 | 0.03 | 0.03 | 0.00 | 0.06 | 0.06 | 0.06 | 0.01 | 0.03 | 0.08 | 0.06 | 0.05 | 0.05 | 0.01 | 0.01 | 0.01 | 0.03 | 0.00 | 0.01 | 0.02 | 0.03 | 0.00 | 0.15 | 0.04 | 0.02 | 0.01 | 0.02 | 0.00 | 0.00 | 0.05 | 0.04 | 0.09 | 0.15 | 0.01 | 0.03 | 0.01 | 0.04 | 0.00 | 0.18 | 0.15 | 0.03 | 0.04 | 0.02 | 0.01 | 0.02 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.03 | 0.00 | 0.00 | 0.03 | 0.03 |
| PRSS37 | ENSG00000165076 | 0.02 | 0.01 | 0.06 | 0.00 | 0.05 | 0.02 | 0.02 | 0.03 | 0.04 | 0.04 | 0.00 | 0.01 | 0.04 | 0.05 | 0.09 | 0.02 | 0.08 | 0.07 | 0.02 | 0.14 | 0.05 | 0.20 | 0.02 | 0.09 | 0.03 | 0.00 | 0.03 | 0.01 | 0.03 | 0.04 | 0.04 | 0.05 | 0.00 | 0.06 | 0.06 | 0.06 | 0.00 | 0.02 | 0.00 | 0.00 | 0.09 | 0.04 | 0.50 | 0.05 | 0.03 | 0.08 | 0.04 | 0.05 | 0.05 | 0.14 | 0.15 | 0.10 | 0.02 | 0.04 | 0.00 | 0.05 | 0.02 | 0.09 | 0.10 | 0.00 | 0.05 | 0.01 | 0.00 | 0.00 | 0.22 | 0.02 |
| FBP1 | ENSG00000165140 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.01 | 0.05 | 0.04 | 0.00 | 0.01 | 0.01 | 0.04 | 0.02 | 0.05 | 0.04 | 0.02 | 0.04 | 0.00 | 0.06 | 0.02 | 0.02 | 0.04 | 0.01 | 0.01 | 0.04 | 0.02 | 0.01 | 0.01 | 0.04 | 0.04 | 0.00 | 0.08 | 0.04 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.03 | 0.07 | 0.14 | 0.02 | 0.02 | 0.01 | 0.05 | 0.00 | 0.11 | 0.10 | 0.01 | 0.04 | 0.02 | 0.00 | 0.02 | 0.00 | 0.02 | 0.01 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.01 | 0.03 |
| CYBB | ENSG00000165168 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.06 | 0.03 | 0.04 | 0.02 | 0.00 | 0.00 | 0.00 | 0.02 | 0.04 | 0.04 | 0.03 | 0.02 | 0.00 | 0.03 | 0.09 | 0.04 | 0.03 | 0.01 | 0.01 | 0.01 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.02 | 0.08 | 0.12 | 0.01 | 0.01 | 0.03 | 0.02 | 0.15 | 0.07 | 0.18 | 0.03 | 0.01 | 0.00 | 0.00 | 0.01 | 0.06 | 0.04 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.01 |
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