Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 76 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| SLC13A3 | ENSG00000158296 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.15 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.04 | 0.09 | 0.01 | 0.00 | 0.01 | 0.05 | 0.00 | 0.16 | 0.00 | 0.15 | 0.00 | 0.15 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.00 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.17 | 0.03 | 0.27 | 0.04 | 0.02 | 0.04 | 0.10 | 0.01 | 0.46 | 0.00 | 0.13 | 0.03 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.09 | 0.00 |
| RHBDL2 | ENSG00000158315 | 0.01 | 0.02 | 0.01 | 0.04 | 0.00 | 0.00 | 0.01 | 0.01 | 0.21 | 0.04 | 0.00 | 0.00 | 0.11 | 0.05 | 0.11 | 0.02 | 0.10 | 0.05 | 0.08 | 0.02 | 0.22 | 0.02 | 0.07 | 0.03 | 0.04 | 0.03 | 0.01 | 0.03 | 0.04 | 0.01 | 0.02 | 0.11 | 0.00 | 0.26 | 0.00 | 0.03 | 0.03 | 0.07 | 0.00 | 0.00 | 0.09 | 0.05 | 0.72 | 0.06 | 0.06 | 0.01 | 0.10 | 0.02 | 0.23 | 0.05 | 0.10 | 0.04 | 0.04 | 0.03 | 0.02 | 0.00 | 0.00 | 0.03 | 0.00 | 0.01 | 0.04 | 0.01 | 0.00 | 0.10 | 0.04 | 0.03 |
| HIST1H4H | ENSG00000158406 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.02 | 0.21 | 0.03 | 0.00 | 0.01 | 0.02 | 0.05 | 0.07 | 0.02 | 0.07 | 0.06 | 0.02 | 0.04 | 0.11 | 0.09 | 0.06 | 0.05 | 0.03 | 0.02 | 0.04 | 0.03 | 0.02 | 0.04 | 0.11 | 0.01 | 0.06 | 0.08 | 0.04 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.12 | 0.03 | 0.36 | 0.05 | 0.10 | 0.03 | 0.05 | 0.01 | 0.20 | 0.02 | 0.03 | 0.07 | 0.02 | 0.01 | 0.01 | 0.00 | 0.05 | 0.01 | 0.01 | 0.02 | 0.01 | 0.00 | 0.11 | 0.00 | 0.13 | 0.01 |
| CD1D | ENSG00000158473 | 0.03 | 0.00 | 0.01 | 0.01 | 0.00 | 0.03 | 0.02 | 0.05 | 0.39 | 0.01 | 0.02 | 0.00 | 0.11 | 0.00 | 0.26 | 0.00 | 0.24 | 0.00 | 0.06 | 0.00 | 0.25 | 0.00 | 0.13 | 0.00 | 0.03 | 0.00 | 0.11 | 0.00 | 0.07 | 0.00 | 0.29 | 0.00 | 0.41 | 0.01 | 0.16 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.28 | 0.01 | 0.38 | 0.02 | 0.16 | 0.00 | 0.15 | 0.00 | 0.29 | 0.00 | 0.37 | 0.03 | 0.11 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.01 | 0.00 | 0.05 | 0.00 | 0.00 | 0.00 | 0.18 | 0.01 |
| CD1B | ENSG00000158485 | 0.03 | 0.00 | 0.01 | 0.01 | 0.00 | 0.03 | 0.02 | 0.05 | 0.40 | 0.02 | 0.02 | 0.00 | 0.11 | 0.00 | 0.27 | 0.00 | 0.24 | 0.00 | 0.06 | 0.00 | 0.25 | 0.00 | 0.13 | 0.00 | 0.03 | 0.00 | 0.11 | 0.00 | 0.07 | 0.00 | 0.29 | 0.00 | 0.41 | 0.01 | 0.16 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.27 | 0.01 | 0.38 | 0.02 | 0.15 | 0.00 | 0.14 | 0.00 | 0.29 | 0.00 | 0.38 | 0.02 | 0.11 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.16 | 0.01 |
| CD1E | ENSG00000158488 | 0.03 | 0.00 | 0.01 | 0.01 | 0.00 | 0.03 | 0.02 | 0.05 | 0.40 | 0.02 | 0.02 | 0.00 | 0.11 | 0.00 | 0.27 | 0.00 | 0.25 | 0.00 | 0.06 | 0.00 | 0.25 | 0.00 | 0.13 | 0.00 | 0.03 | 0.00 | 0.11 | 0.00 | 0.07 | 0.00 | 0.29 | 0.00 | 0.41 | 0.01 | 0.16 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.27 | 0.01 | 0.37 | 0.02 | 0.15 | 0.00 | 0.14 | 0.00 | 0.29 | 0.00 | 0.38 | 0.02 | 0.11 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.16 | 0.01 |
| CPA5 | ENSG00000158525 | 0.01 | 0.01 | 0.13 | 0.00 | 0.01 | 0.00 | 0.02 | 0.04 | 0.04 | 0.04 | 0.00 | 0.01 | 0.04 | 0.05 | 0.08 | 0.02 | 0.06 | 0.06 | 0.02 | 0.13 | 0.05 | 0.18 | 0.03 | 0.07 | 0.02 | 0.00 | 0.03 | 0.02 | 0.01 | 0.04 | 0.05 | 0.04 | 0.00 | 0.02 | 0.04 | 0.06 | 0.00 | 0.01 | 0.00 | 0.00 | 0.10 | 0.03 | 0.40 | 0.03 | 0.03 | 0.07 | 0.07 | 0.05 | 0.15 | 0.14 | 0.14 | 0.04 | 0.02 | 0.03 | 0.00 | 0.05 | 0.02 | 0.11 | 0.13 | 0.00 | 0.09 | 0.00 | 0.00 | 0.00 | 0.19 | 0.01 |
| SLAMF8 | ENSG00000158714 | 0.03 | 0.00 | 0.01 | 0.01 | 0.00 | 0.03 | 0.02 | 0.03 | 0.71 | 0.00 | 0.02 | 0.00 | 0.10 | 0.00 | 0.28 | 0.00 | 0.27 | 0.00 | 0.06 | 0.00 | 0.27 | 0.00 | 0.12 | 0.00 | 0.03 | 0.00 | 0.13 | 0.00 | 0.06 | 0.00 | 0.28 | 0.00 | 0.30 | 0.01 | 0.16 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.27 | 0.01 | 0.41 | 0.02 | 0.16 | 0.00 | 0.14 | 0.00 | 0.28 | 0.00 | 0.40 | 0.02 | 0.10 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.16 | 0.00 |
| DUSP23 | ENSG00000158716 | 0.03 | 0.00 | 0.01 | 0.01 | 0.00 | 0.03 | 0.02 | 0.03 | 0.67 | 0.00 | 0.02 | 0.00 | 0.10 | 0.00 | 0.28 | 0.00 | 0.27 | 0.00 | 0.06 | 0.00 | 0.27 | 0.00 | 0.12 | 0.00 | 0.03 | 0.00 | 0.13 | 0.00 | 0.06 | 0.00 | 0.28 | 0.00 | 0.30 | 0.01 | 0.16 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.27 | 0.01 | 0.39 | 0.02 | 0.16 | 0.00 | 0.13 | 0.00 | 0.28 | 0.00 | 0.42 | 0.02 | 0.10 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.16 | 0.01 |
| OR10J6P | ENSG00000158731 | 0.03 | 0.00 | 0.01 | 0.01 | 0.00 | 0.03 | 0.02 | 0.04 | 0.59 | 0.00 | 0.02 | 0.00 | 0.11 | 0.00 | 0.27 | 0.00 | 0.25 | 0.00 | 0.05 | 0.00 | 0.27 | 0.00 | 0.12 | 0.00 | 0.03 | 0.00 | 0.11 | 0.00 | 0.06 | 0.00 | 0.29 | 0.00 | 0.30 | 0.01 | 0.16 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.26 | 0.01 | 0.38 | 0.02 | 0.17 | 0.00 | 0.13 | 0.00 | 0.28 | 0.00 | 0.37 | 0.03 | 0.10 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.16 | 0.01 |
| NBL1 | ENSG00000158747 | 0.00 | 0.06 | 0.00 | 0.08 | 0.00 | 0.00 | 0.01 | 0.04 | 0.07 | 0.09 | 0.00 | 0.01 | 0.04 | 0.25 | 0.05 | 0.06 | 0.03 | 0.11 | 0.04 | 0.08 | 0.06 | 0.08 | 0.08 | 0.11 | 0.00 | 0.16 | 0.00 | 0.22 | 0.01 | 0.07 | 0.03 | 0.22 | 0.00 | 1.11 | 0.03 | 0.07 | 0.01 | 0.10 | 0.00 | 0.00 | 0.02 | 0.20 | 0.13 | 0.43 | 0.04 | 0.08 | 0.05 | 0.13 | 0.03 | 0.15 | 0.18 | 0.13 | 0.05 | 0.07 | 0.02 | 0.01 | 0.00 | 0.03 | 0.00 | 0.02 | 0.03 | 0.09 | 0.00 | 0.12 | 0.06 | 0.09 |
| HTR6 | ENSG00000158748 | 0.00 | 0.06 | 0.00 | 0.08 | 0.00 | 0.00 | 0.01 | 0.04 | 0.07 | 0.09 | 0.00 | 0.01 | 0.04 | 0.25 | 0.05 | 0.07 | 0.03 | 0.11 | 0.04 | 0.08 | 0.06 | 0.08 | 0.08 | 0.11 | 0.00 | 0.16 | 0.00 | 0.22 | 0.01 | 0.07 | 0.02 | 0.22 | 0.00 | 1.11 | 0.03 | 0.07 | 0.01 | 0.10 | 0.00 | 0.00 | 0.02 | 0.20 | 0.13 | 0.44 | 0.04 | 0.08 | 0.05 | 0.13 | 0.03 | 0.15 | 0.18 | 0.13 | 0.05 | 0.06 | 0.02 | 0.01 | 0.00 | 0.03 | 0.00 | 0.02 | 0.03 | 0.09 | 0.00 | 0.12 | 0.06 | 0.09 |
| ITLN2 | ENSG00000158764 | 0.03 | 0.00 | 0.02 | 0.01 | 0.00 | 0.03 | 0.02 | 0.05 | 0.95 | 0.01 | 0.02 | 0.00 | 0.10 | 0.02 | 0.27 | 0.00 | 0.28 | 0.00 | 0.06 | 0.00 | 0.28 | 0.00 | 0.14 | 0.00 | 0.03 | 0.00 | 0.12 | 0.00 | 0.06 | 0.00 | 0.30 | 0.00 | 0.30 | 0.01 | 0.16 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.33 | 0.00 | 0.37 | 0.02 | 0.18 | 0.00 | 0.15 | 0.00 | 0.41 | 0.00 | 0.46 | 0.02 | 0.11 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.16 | 0.01 |
| PLA2G2F | ENSG00000158786 | 0.00 | 0.06 | 0.00 | 0.08 | 0.00 | 0.00 | 0.01 | 0.03 | 0.07 | 0.09 | 0.00 | 0.01 | 0.04 | 0.25 | 0.05 | 0.06 | 0.03 | 0.11 | 0.03 | 0.07 | 0.06 | 0.09 | 0.07 | 0.11 | 0.00 | 0.16 | 0.00 | 0.22 | 0.01 | 0.07 | 0.03 | 0.22 | 0.00 | 1.11 | 0.01 | 0.06 | 0.01 | 0.10 | 0.00 | 0.00 | 0.02 | 0.20 | 0.13 | 0.43 | 0.04 | 0.08 | 0.05 | 0.13 | 0.03 | 0.19 | 0.18 | 0.13 | 0.05 | 0.06 | 0.02 | 0.01 | 0.00 | 0.07 | 0.00 | 0.03 | 0.04 | 0.10 | 0.00 | 0.12 | 0.06 | 0.09 |
| EDA | ENSG00000158813 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.02 | 0.01 | 0.04 | 0.05 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.02 | 0.04 | 0.04 | 0.02 | 0.01 | 0.13 | 0.03 | 0.01 | 0.02 | 0.01 | 0.01 | 0.00 | 0.02 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.02 | 0.15 | 0.04 | 0.03 | 0.02 | 0.05 | 0.01 | 0.20 | 0.00 | 0.17 | 0.07 | 0.01 | 0.01 | 0.00 | 0.01 | 0.01 | 0.02 | 0.03 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 |
| FGF17 | ENSG00000158815 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.23 | 0.00 | 0.14 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.07 | 0.00 | 0.09 | 0.00 | 0.06 | 0.01 | 0.07 | 0.03 | 0.04 | 0.00 | 0.12 | 0.01 | 0.18 | 0.00 | 0.05 | 0.03 | 0.12 | 0.00 | 0.05 | 0.02 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.01 | 0.15 | 0.02 | 0.43 | 0.00 | 0.06 | 0.01 | 0.08 | 0.10 | 0.24 | 0.02 | 0.05 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.11 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.01 | 0.02 | 0.04 |
| CDA | ENSG00000158825 | 0.00 | 0.06 | 0.00 | 0.08 | 0.00 | 0.00 | 0.01 | 0.03 | 0.08 | 0.09 | 0.00 | 0.01 | 0.04 | 0.24 | 0.05 | 0.06 | 0.03 | 0.11 | 0.03 | 0.07 | 0.04 | 0.09 | 0.06 | 0.11 | 0.00 | 0.16 | 0.00 | 0.22 | 0.01 | 0.08 | 0.02 | 0.21 | 0.00 | 1.10 | 0.01 | 0.05 | 0.01 | 0.09 | 0.00 | 0.00 | 0.02 | 0.19 | 0.09 | 0.44 | 0.05 | 0.08 | 0.05 | 0.13 | 0.01 | 0.21 | 0.18 | 0.13 | 0.05 | 0.06 | 0.02 | 0.00 | 0.00 | 0.07 | 0.00 | 0.03 | 0.03 | 0.09 | 0.00 | 0.12 | 0.06 | 0.09 |
| PINK1 | ENSG00000158828 | 0.00 | 0.06 | 0.00 | 0.08 | 0.00 | 0.00 | 0.01 | 0.03 | 0.08 | 0.09 | 0.00 | 0.01 | 0.04 | 0.25 | 0.05 | 0.06 | 0.03 | 0.11 | 0.03 | 0.07 | 0.04 | 0.09 | 0.06 | 0.11 | 0.00 | 0.16 | 0.00 | 0.22 | 0.01 | 0.09 | 0.02 | 0.21 | 0.00 | 1.11 | 0.01 | 0.05 | 0.01 | 0.10 | 0.00 | 0.00 | 0.02 | 0.20 | 0.09 | 0.44 | 0.05 | 0.08 | 0.05 | 0.13 | 0.01 | 0.24 | 0.18 | 0.13 | 0.05 | 0.06 | 0.02 | 0.00 | 0.00 | 0.07 | 0.00 | 0.03 | 0.03 | 0.09 | 0.00 | 0.12 | 0.06 | 0.09 |
| ADAMTS4 | ENSG00000158859 | 0.03 | 0.00 | 0.01 | 0.01 | 0.00 | 0.03 | 0.02 | 0.05 | 0.96 | 0.00 | 0.02 | 0.00 | 0.10 | 0.01 | 0.27 | 0.00 | 0.28 | 0.00 | 0.06 | 0.00 | 0.33 | 0.00 | 0.14 | 0.00 | 0.03 | 0.00 | 0.14 | 0.00 | 0.06 | 0.00 | 0.32 | 0.00 | 0.30 | 0.01 | 0.16 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.33 | 0.00 | 0.37 | 0.02 | 0.18 | 0.00 | 0.16 | 0.00 | 0.41 | 0.00 | 0.43 | 0.03 | 0.10 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.17 | 0.01 |
| APOA2 | ENSG00000158874 | 0.03 | 0.00 | 0.01 | 0.01 | 0.00 | 0.03 | 0.02 | 0.05 | 0.95 | 0.00 | 0.02 | 0.00 | 0.10 | 0.01 | 0.26 | 0.00 | 0.27 | 0.00 | 0.06 | 0.00 | 0.33 | 0.00 | 0.14 | 0.00 | 0.03 | 0.00 | 0.14 | 0.00 | 0.06 | 0.00 | 0.33 | 0.00 | 0.30 | 0.01 | 0.16 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.33 | 0.00 | 0.36 | 0.02 | 0.18 | 0.00 | 0.16 | 0.00 | 0.41 | 0.00 | 0.39 | 0.03 | 0.10 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.17 | 0.01 |
|
Showing page 76 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.