Copy Number

 

The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).

 

Summary of the G-score of the PDGs in each cancer type


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KIRCKIRPKICHPRADBLCATHYMMESOLUADLUSCHNSCESCASTADCOADREADPAADLIHCCHOLACCPCPGTHCABRCAOVCESCUCECUCSSARCTGCTLAMLDLBCLGGGBMUVMSKCM
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SSTENSG00000157005  0.05    0.00    0.03    0.02    0.00    0.01    0.03    0.04    0.19    0.00    0.00    0.00    0.00    0.07    0.13    0.05    1.49    0.00    0.60    0.00    0.70    0.02    0.22    0.01    0.04    0.01    0.06    0.02    0.03    0.00    0.11    0.02    0.12    0.03    0.10    0.00    0.00    0.10    0.00    0.00    0.20    0.02    1.00    0.05    0.62    0.00    0.35    0.01    0.72    0.09    0.12    0.09    0.24    0.00    0.00    0.00    0.06    0.02    0.01    0.03    0.11    0.06    0.00    0.00    0.03    0.04  
GHRLENSG00000157017  0.00    0.18    0.00    0.01    0.07    0.00    0.01    0.06    0.40    0.03    0.00    0.03    0.03    0.06    0.04    0.04    0.03    0.04    0.01    0.02    0.08    0.05    0.07    0.05    0.00    0.04    0.03    0.06    0.01    0.02    0.07    0.01    0.00    0.18    0.07    0.01    0.01    0.04    0.00    0.00    0.12    0.02    0.15    0.22    0.02    0.01    0.05    0.03    0.05    0.14    0.20    0.05    0.04    0.05    0.00    0.00    0.00    0.05    0.03    0.01    0.03    0.01    0.00    0.00    0.02    0.05  
EXOGENSG00000157036  0.00    0.18    0.00    0.01    0.08    0.00    0.00    0.01    0.14    0.04    0.00    0.03    0.02    0.28    0.01    0.04    0.02    0.05    0.00    0.04    0.03    0.04    0.05    0.08    0.00    0.03    0.04    0.02    0.01    0.02    0.04    0.02    0.00    0.20    0.05    0.02    0.00    0.03    0.00    0.00    0.04    0.09    0.11    0.16    0.02    0.04    0.03    0.04    0.12    0.13    0.08    0.06    0.03    0.04    0.00    0.01    0.00    0.09    0.01    0.03    0.01    0.03    0.00    0.03    0.04    0.05  
LYZL4ENSG00000157093  0.00    0.18    0.00    0.02    0.08    0.00    0.01    0.01    0.06    0.08    0.00    0.03    0.01    0.37    0.01    0.04    0.00    0.07    0.00    0.04    0.04    0.04    0.02    0.08    0.00    0.02    0.04    0.05    0.00    0.03    0.04    0.02    0.00    0.20    0.01    0.02    0.00    0.03    0.00    0.00    0.02    0.12    0.09    0.16    0.02    0.04    0.02    0.05    0.02    0.19    0.07    0.10    0.01    0.04    0.00    0.01    0.00    0.07    0.01    0.04    0.01    0.04    0.00    0.03    0.03    0.04  
SLC6A1ENSG00000157103  0.00    0.19    0.00    0.01    0.07    0.00    0.00    0.05    0.48    0.03    0.00    0.03    0.03    0.06    0.04    0.05    0.02    0.05    0.01    0.03    0.04    0.05    0.07    0.06    0.00    0.04    0.03    0.06    0.01    0.02    0.06    0.01    0.00    0.18    0.07    0.01    0.00    0.04    0.00    0.00    0.12    0.03    0.14    0.22    0.01    0.02    0.05    0.03    0.05    0.14    0.24    0.03    0.04    0.05    0.00    0.00    0.00    0.05    0.03    0.01    0.02    0.02    0.00    0.00    0.01    0.05  
KLHL40ENSG00000157119  0.00    0.18    0.00    0.02    0.08    0.00    0.01    0.01    0.06    0.08    0.00    0.03    0.01    0.39    0.01    0.04    0.00    0.07    0.00    0.04    0.01    0.04    0.01    0.08    0.00    0.02    0.04    0.05    0.00    0.03    0.06    0.02    0.00    0.20    0.01    0.02    0.00    0.03    0.00    0.00    0.02    0.12    0.09    0.17    0.02    0.04    0.02    0.04    0.02    0.19    0.06    0.10    0.01    0.04    0.00    0.01    0.00    0.10    0.01    0.04    0.01    0.04    0.00    0.03    0.02    0.04  
TIMP4ENSG00000157150  0.00    0.18    0.00    0.01    0.07    0.00    0.00    0.04    0.70    0.01    0.00    0.03    0.03    0.08    0.03    0.04    0.02    0.03    0.02    0.02    0.05    0.06    0.08    0.05    0.02    0.03    0.03    0.06    0.01    0.02    0.06    0.01    0.00    0.18    0.07    0.01    0.00    0.04    0.00    0.00    0.12    0.03    0.12    0.22    0.03    0.01    0.07    0.03    0.05    0.14    0.24    0.02    0.04    0.05    0.00    0.00    0.00    0.05    0.03    0.01    0.01    0.02    0.00    0.00    0.02    0.05  
C1orf27ENSG00000157181  0.02    0.00    0.01    0.00    0.00    0.00    0.01    0.03    0.20    0.04    0.02    0.00    0.10    0.03    0.10    0.00    0.15    0.01    0.06    0.01    0.19    0.03    0.08    0.01    0.04    0.01    0.15    0.01    0.04    0.00    0.15    0.02    0.20    0.01    0.02    0.05    0.01    0.00    0.01    0.00    0.17    0.01    0.34    0.04    0.09    0.00    0.06    0.00    0.20    0.03    0.22    0.06    0.07    0.00    0.01    0.00    0.30    0.02    0.01    0.01    0.01    0.01    0.04    0.00    0.13    0.03  
CDCP2ENSG00000157211  0.00    0.01    0.02    0.01    0.00    0.00    0.00    0.06    0.09    0.04    0.00    0.00    0.06    0.04    0.06    0.04    0.05    0.03    0.04    0.03    0.09    0.03    0.03    0.04    0.01    0.04    0.01    0.04    0.01    0.01    0.04    0.05    0.00    0.25    0.04    0.03    0.00    0.17    0.00    0.00    0.08    0.04    0.34    0.10    0.07    0.02    0.05    0.02    0.13    0.04    0.21    0.03    0.05    0.03    0.02    0.00    0.00    0.07    0.00    0.01    0.02    0.02    0.00    0.07    0.05    0.03  
HTR5AENSG00000157219  0.03    0.01    0.04    0.00    0.05    0.02    0.01    0.04    0.04    0.07    0.00    0.01    0.01    0.03    0.10    0.02    0.07    0.11    0.03    0.16    0.10    0.26    0.03    0.09    0.02    0.01    0.01    0.04    0.03    0.05    0.06    0.05    0.00    0.07    0.05    0.09    0.00    0.02    0.00    0.00    0.09    0.07    0.54    0.09    0.03    0.07    0.04    0.07    0.07    0.23    0.07    0.16    0.01    0.05    0.00    0.06    0.02    0.09    0.10    0.01    0.05    0.02    0.00    0.03    0.17    0.05  
FZD1ENSG00000157240  0.01    0.00    0.04    0.00    0.00    0.00    0.04    0.00    0.05    0.01    0.00    0.00    0.03    0.00    0.07    0.01    0.24    0.01    0.18    0.01    0.62    0.01    0.39    0.01    0.03    0.00    0.01    0.00    0.11    0.00    0.12    0.02    0.18    0.01    0.11    0.01    0.00    0.02    0.00    0.00    0.06    0.02    0.16    0.08    0.07    0.01    0.04    0.02    0.08    0.03    0.12    0.04    0.13    0.00    0.00    0.01    0.13    0.00    0.02    0.00    0.05    0.01    0.00    0.00    0.02    0.02  
IL34ENSG00000157368  0.00    0.00    0.01    0.00    0.00    0.06    0.01    0.14    0.15    0.02    0.00    0.00    0.00    0.10    0.03    0.04    0.03    0.02    0.03    0.02    0.09    0.01    0.05    0.02    0.01    0.00    0.02    0.01    0.01    0.00    0.02    0.04    0.09    0.01    0.14    0.03    0.02    0.00    0.00    0.01    0.04    0.05    0.06    0.31    0.04    0.04    0.06    0.08    0.15    0.16    0.06    0.03    0.09    0.03    0.00    0.05    0.00    0.00    0.00    0.00    0.00    0.03    0.00    0.02    0.04    0.01  
ARSEENSG00000157399  0.00    0.00    0.01    0.00    0.00    0.00    0.04    0.01    0.08    0.07    0.00    0.00    0.00    0.00    0.03    0.07    0.11    0.07    0.03    0.03    0.07    0.12    0.07    0.04    0.02    0.02    0.07    0.08    0.00    0.00    0.02    0.04    0.02    0.01    0.11    0.00    0.03    0.00    0.00    0.00    0.06    0.05    0.20    0.20    0.09    0.02    0.05    0.04    0.09    0.11    0.21    0.11    0.05    0.02    0.00    0.00    0.00    0.07    0.04    0.02    0.02    0.01    0.00    0.01    0.04    0.02  
CCNB2ENSG00000157456  0.00    0.00    0.00    0.01    0.14    0.02    0.01    0.03    0.03    0.05    0.00    0.00    0.08    0.02    0.02    0.04    0.03    0.04    0.01    0.03    0.05    0.06    0.02    0.06    0.01    0.04    0.00    0.06    0.01    0.02    0.02    0.01    0.00    0.01    0.04    0.03    0.00    0.01    0.00    0.00    0.03    0.06    0.05    0.14    0.03    0.06    0.01    0.07    0.00    0.26    0.10    0.02    0.01    0.02    0.00    0.00    0.06    0.02    0.01    0.02    0.01    0.05    0.00    0.00    0.04    0.06  
SLC35B2ENSG00000157593  0.01    0.01    0.01    0.00    0.00    0.00    0.01    0.01    0.19    0.02    0.00    0.00    0.01    0.02    0.13    0.01    0.13    0.04    0.06    0.02    0.58    0.02    0.37    0.01    0.10    0.00    0.20    0.00    0.03    0.00    0.14    0.00    0.05    0.01    0.09    0.00    0.00    0.00    0.00    0.00    0.13    0.03    0.24    0.06    0.08    0.02    0.07    0.01    0.08    0.03    0.25    0.04    0.06    0.01    0.00    0.00    0.09    0.05    0.01    0.00    0.03    0.01    0.02    0.00    0.06    0.00  
PSMG3ENSG00000157778  0.01    0.01    0.01    0.00    0.00    0.00    0.01    0.02    0.15    0.02    0.00    0.00    0.10    0.00    0.11    0.01    0.14    0.04    0.12    0.01    0.27    0.02    0.16    0.01    0.05    0.01    0.05    0.01    0.05    0.00    0.07    0.02    0.01    0.01    0.09    0.03    0.00    0.01    0.00    0.00    0.09    0.06    0.14    0.39    0.04    0.02    0.04    0.07    0.12    0.05    0.14    0.04    0.15    0.01    0.00    0.01    0.15    0.00    0.01    0.04    0.04    0.01    0.00    0.00    0.16    0.02  
SPPL3ENSG00000157837  0.01    0.01    0.02    0.00    0.06    0.02    0.04    0.05    0.10    0.05    0.00    0.00    0.01    0.02    0.02    0.06    0.02    0.08    0.03    0.03    0.09    0.06    0.08    0.04    0.01    0.01    0.04    0.01    0.00    0.06    0.03    0.09    0.00    0.17    0.13    0.01    0.00    0.03    0.00    0.00    0.04    0.10    0.14    0.22    0.02    0.02    0.04    0.06    0.14    0.26    0.16    0.05    0.01    0.00    0.00    0.00    0.10    0.03    0.03    0.01    0.01    0.01    0.07    0.00    0.02    0.06  
SLC30A2ENSG00000158014  0.00    0.06    0.00    0.08    0.00    0.00    0.01    0.02    0.06    0.08    0.00    0.01    0.05    0.19    0.04    0.07    0.04    0.11    0.02    0.07    0.01    0.13    0.02    0.13    0.00    0.17    0.00    0.22    0.01    0.10    0.01    0.21    0.00    1.06    0.01    0.10    0.01    0.07    0.00    0.00    0.02    0.18    0.09    0.44    0.04    0.07    0.02    0.13    0.03    0.18    0.14    0.09    0.04    0.06    0.02    0.00    0.00    0.11    0.00    0.02    0.02    0.08    0.00    0.09    0.05    0.06  
DUSP2ENSG00000158050  0.00    0.00    0.00    0.01    0.00    0.00    0.02    0.01    0.09    0.01    0.00    0.00    0.00    0.00    0.06    0.01    0.15    0.01    0.10    0.01    0.13    0.01    0.07    0.01    0.01    0.00    0.01    0.01    0.00    0.01    0.01    0.00    0.00    0.01    0.03    0.00    0.00    0.00    0.00    0.00    0.06    0.02    0.18    0.05    0.03    0.01    0.06    0.01    0.32    0.00    0.19    0.01    0.01    0.01    0.00    0.00    0.00    0.02    0.00    0.00    0.01    0.00    0.00    0.00    0.02    0.01  
XDHENSG00000158125  0.00    0.00    0.03    0.02    0.00    0.00    0.01    0.04    0.08    0.01    0.00    0.00    0.03    0.07    0.05    0.02    0.11    0.02    0.03    0.01    0.05    0.04    0.02    0.03    0.00    0.01    0.00    0.03    0.01    0.03    0.06    0.00    0.00    0.05    0.01    0.03    0.00    0.00    0.00    0.00    0.06    0.02    0.22    0.06    0.09    0.00    0.07    0.01    0.16    0.00    0.09    0.05    0.14    0.01    0.00    0.00    0.00    0.03    0.00    0.00    0.02    0.01    0.05    0.00    0.03    0.02  

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