Copy Number

 

The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).

 

Summary of the G-score of the PDGs in each cancer type


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KIRCKIRPKICHPRADBLCATHYMMESOLUADLUSCHNSCESCASTADCOADREADPAADLIHCCHOLACCPCPGTHCABRCAOVCESCUCECUCSSARCTGCTLAMLDLBCLGGGBMUVMSKCM
 HGNC Symbol  Ensembl Gene ID  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del 
ULBP1ENSG00000111981  0.00    0.06    0.00    0.01    0.00    0.05    0.01    0.03    0.04    0.08    0.00    0.03    0.00    0.17    0.01    0.06    0.06    0.05    0.03    0.04    0.08    0.05    0.09    0.05    0.02    0.01    0.04    0.03    0.00    0.04    0.01    0.11    0.00    0.16    0.11    0.03    0.00    0.02    0.00    0.00    0.11    0.07    0.03    0.41    0.01    0.07    0.02    0.04    0.08    0.03    0.33    0.03    0.01    0.04    0.00    0.00    0.00    0.09    0.00    0.05    0.00    0.09    0.03    0.06    0.02    0.13  
TULP1ENSG00000112041  0.00    0.00    0.01    0.01    0.00    0.00    0.01    0.01    0.07    0.04    0.00    0.00    0.03    0.01    0.08    0.01    0.03    0.05    0.03    0.03    0.12    0.04    0.07    0.03    0.03    0.01    0.05    0.01    0.04    0.01    0.06    0.01    0.05    0.03    0.03    0.00    0.00    0.00    0.00    0.00    0.08    0.03    0.26    0.05    0.07    0.01    0.04    0.01    0.36    0.07    0.10    0.07    0.04    0.01    0.00    0.00    0.08    0.00    0.01    0.00    0.02    0.00    0.10    0.00    0.09    0.00  
SLC26A8ENSG00000112053  0.00    0.00    0.01    0.01    0.00    0.00    0.01    0.01    0.08    0.04    0.00    0.00    0.02    0.01    0.08    0.01    0.03    0.05    0.03    0.03    0.15    0.04    0.07    0.03    0.03    0.01    0.06    0.01    0.09    0.01    0.06    0.03    0.05    0.03    0.07    0.00    0.00    0.00    0.00    0.00    0.07    0.03    0.25    0.05    0.08    0.00    0.05    0.01    0.22    0.07    0.13    0.07    0.05    0.01    0.00    0.00    0.08    0.00    0.01    0.00    0.03    0.00    0.10    0.00    0.09    0.01  
SOD2ENSG00000112096  0.00    0.06    0.00    0.01    0.00    0.05    0.00    0.05    0.02    0.08    0.00    0.02    0.00    0.17    0.02    0.06    0.07    0.06    0.03    0.04    0.08    0.06    0.07    0.07    0.02    0.01    0.03    0.03    0.00    0.03    0.01    0.12    0.00    0.18    0.09    0.03    0.00    0.02    0.00    0.00    0.05    0.12    0.07    0.44    0.00    0.10    0.03    0.04    0.08    0.05    0.21    0.05    0.01    0.05    0.00    0.00    0.06    0.02    0.00    0.05    0.00    0.09    0.06    0.06    0.02    0.15  
IL17FENSG00000112116  0.00    0.00    0.02    0.02    0.00    0.00    0.01    0.01    0.10    0.04    0.00    0.00    0.00    0.03    0.08    0.01    0.22    0.03    0.08    0.02    0.29    0.03    0.16    0.01    0.03    0.01    0.11    0.02    0.01    0.01    0.09    0.00    0.00    0.01    0.03    0.00    0.00    0.00    0.00    0.00    0.11    0.02    0.17    0.06    0.09    0.03    0.06    0.01    0.20    0.03    0.09    0.04    0.01    0.00    0.00    0.00    0.09    0.02    0.01    0.00    0.01    0.02    0.01    0.00    0.04    0.02  
CD83ENSG00000112149  0.00    0.00    0.00    0.01    0.00    0.00    0.01    0.01    0.38    0.04    0.00    0.01    0.01    0.02    0.08    0.01    0.09    0.08    0.05    0.05    0.09    0.17    0.03    0.08    0.02    0.03    0.01    0.03    0.00    0.07    0.14    0.01    0.06    0.03    0.01    0.01    0.00    0.01    0.00    0.00    0.17    0.04    0.51    0.05    0.09    0.05    0.06    0.02    0.25    0.02    0.08    0.13    0.04    0.03    0.00    0.00    0.05    0.04    0.01    0.02    0.01    0.01    0.25    0.00    0.23    0.00  
GLP1RENSG00000112164  0.01    0.00    0.01    0.00    0.00    0.00    0.01    0.00    0.12    0.03    0.01    0.00    0.02    0.02    0.10    0.02    0.08    0.04    0.04    0.03    0.26    0.03    0.13    0.02    0.05    0.01    0.08    0.00    0.01    0.01    0.05    0.02    0.05    0.03    0.03    0.00    0.02    0.00    0.00    0.00    0.10    0.03    0.30    0.05    0.05    0.01    0.03    0.01    0.09    0.03    0.11    0.05    0.05    0.01    0.00    0.00    0.11    0.00    0.02    0.00    0.02    0.00    0.09    0.00    0.05    0.00  
TSPO2ENSG00000112212  0.01    0.00    0.01    0.00    0.00    0.00    0.02    0.01    0.14    0.03    0.01    0.00    0.02    0.03    0.14    0.01    0.09    0.05    0.06    0.02    0.42    0.02    0.25    0.01    0.10    0.00    0.10    0.00    0.03    0.00    0.07    0.00    0.05    0.03    0.03    0.00    0.00    0.00    0.00    0.00    0.10    0.03    0.29    0.05    0.05    0.01    0.03    0.01    0.06    0.03    0.19    0.03    0.05    0.01    0.00    0.00    0.14    0.00    0.01    0.00    0.00    0.01    0.04    0.00    0.04    0.00  
GPR63ENSG00000112218  0.00    0.02    0.00    0.00    0.00    0.00    0.01    0.32    0.03    0.10    0.00    0.00    0.02    0.08    0.01    0.05    0.03    0.05    0.02    0.03    0.01    0.10    0.03    0.07    0.00    0.03    0.01    0.02    0.00    0.03    0.01    0.06    0.00    0.08    0.04    0.02    0.00    0.00    0.00    0.00    0.06    0.10    0.13    0.15    0.01    0.01    0.02    0.01    0.03    0.05    0.10    0.12    0.00    0.01    0.00    0.00    0.00    0.24    0.00    0.01    0.00    0.05    0.05    0.03    0.02    0.06  
PTP4A1ENSG00000112245  0.01    0.00    0.01    0.01    0.00    0.00    0.01    0.04    0.12    0.06    0.00    0.00    0.02    0.04    0.09    0.04    0.26    0.02    0.14    0.01    0.23    0.03    0.17    0.04    0.04    0.01    0.07    0.00    0.01    0.01    0.17    0.02    0.04    0.08    0.05    0.02    0.00    0.00    0.00    0.00    0.11    0.04    0.20    0.06    0.06    0.01    0.05    0.00    0.08    0.02    0.08    0.05    0.00    0.00    0.00    0.00    0.01    0.02    0.00    0.01    0.01    0.03    0.05    0.00    0.17    0.02  
HDGFL1ENSG00000112273  0.00    0.01    0.00    0.01    0.00    0.00    0.01    0.02    0.93    0.01    0.00    0.01    0.01    0.02    0.08    0.01    0.08    0.06    0.02    0.06    0.17    0.14    0.04    0.06    0.03    0.03    0.02    0.03    0.02    0.06    0.15    0.01    0.06    0.03    0.06    0.00    0.00    0.00    0.00    0.00    0.16    0.03    0.46    0.04    0.09    0.05    0.05    0.02    0.21    0.02    0.05    0.10    0.02    0.01    0.00    0.00    0.05    0.01    0.02    0.02    0.02    0.01    0.21    0.00    0.17    0.00  
GMNNENSG00000112312  0.00    0.01    0.00    0.01    0.00    0.00    0.02    0.01    0.32    0.02    0.00    0.01    0.01    0.05    0.06    0.02    0.08    0.05    0.02    0.05    0.13    0.11    0.05    0.06    0.04    0.03    0.02    0.03    0.03    0.04    0.12    0.01    0.06    0.03    0.01    0.01    0.00    0.00    0.00    0.00    0.13    0.03    0.40    0.05    0.09    0.05    0.05    0.02    0.20    0.02    0.04    0.09    0.02    0.01    0.00    0.00    0.05    0.01    0.01    0.02    0.03    0.01    0.18    0.00    0.15    0.01  
NR2E1ENSG00000112333  0.00    0.03    0.00    0.00    0.00    0.00    0.00    0.30    0.05    0.13    0.00    0.01    0.00    0.14    0.02    0.06    0.04    0.05    0.02    0.03    0.04    0.07    0.09    0.07    0.01    0.03    0.01    0.02    0.00    0.03    0.01    0.09    0.00    0.15    0.05    0.02    0.00    0.01    0.00    0.00    0.18    0.10    0.11    0.23    0.04    0.02    0.05    0.02    0.09    0.03    0.06    0.08    0.00    0.04    0.01    0.00    0.00    0.26    0.00    0.02    0.04    0.04    0.04    0.00    0.00    0.13  
SLC17A2ENSG00000112337  0.00    0.01    0.00    0.01    0.00    0.00    0.01    0.01    0.27    0.02    0.00    0.01    0.02    0.03    0.07    0.02    0.07    0.06    0.02    0.04    0.10    0.11    0.04    0.04    0.03    0.03    0.04    0.03    0.03    0.03    0.11    0.02    0.06    0.08    0.01    0.01    0.00    0.00    0.00    0.00    0.14    0.02    0.38    0.05    0.09    0.04    0.05    0.01    0.20    0.02    0.04    0.07    0.01    0.01    0.00    0.00    0.00    0.01    0.01    0.01    0.01    0.00    0.16    0.00    0.16    0.01  
OR12D3ENSG00000112462  0.01    0.00    0.00    0.01    0.00    0.00    0.01    0.00    0.16    0.02    0.00    0.00    0.02    0.02    0.08    0.02    0.07    0.06    0.03    0.04    0.13    0.08    0.08    0.05    0.04    0.02    0.06    0.01    0.04    0.02    0.10    0.01    0.06    0.03    0.01    0.00    0.00    0.00    0.00    0.00    0.09    0.02    0.31    0.05    0.09    0.04    0.03    0.01    0.26    0.02    0.03    0.05    0.01    0.01    0.00    0.00    0.05    0.10    0.01    0.01    0.00    0.01    0.13    0.00    0.14    0.01  
SLC39A7ENSG00000112473  0.00    0.00    0.00    0.01    0.00    0.00    0.01    0.00    0.06    0.04    0.00    0.00    0.02    0.02    0.07    0.01    0.05    0.05    0.02    0.04    0.14    0.04    0.08    0.04    0.03    0.02    0.06    0.01    0.01    0.02    0.07    0.01    0.05    0.03    0.03    0.00    0.00    0.00    0.00    0.00    0.08    0.02    0.27    0.05    0.09    0.01    0.04    0.01    0.05    0.01    0.03    0.07    0.00    0.01    0.00    0.00    0.05    0.06    0.01    0.00    0.01    0.01    0.11    0.00    0.11    0.01  
CCR6ENSG00000112486  0.00    0.06    0.00    0.02    0.00    0.05    0.00    0.05    0.03    0.11    0.00    0.01    0.02    0.09    0.02    0.06    0.08    0.07    0.04    0.04    0.12    0.05    0.10    0.08    0.02    0.02    0.03    0.03    0.00    0.03    0.03    0.13    0.00    0.18    0.10    0.08    0.00    0.04    0.01    0.00    0.07    0.13    0.07    0.45    0.00    0.09    0.03    0.05    0.20    0.06    0.21    0.07    0.01    0.06    0.00    0.00    0.11    0.02    0.00    0.04    0.00    0.12    0.00    0.06    0.04    0.15  
SLC22A2ENSG00000112499  0.00    0.06    0.00    0.01    0.00    0.05    0.00    0.04    0.02    0.08    0.00    0.02    0.00    0.20    0.02    0.07    0.07    0.05    0.03    0.04    0.09    0.05    0.06    0.07    0.02    0.01    0.03    0.02    0.00    0.03    0.02    0.12    0.00    0.18    0.14    0.03    0.00    0.02    0.01    0.00    0.06    0.12    0.07    0.44    0.00    0.10    0.03    0.04    0.08    0.05    0.20    0.05    0.01    0.05    0.00    0.00    0.06    0.02    0.00    0.05    0.00    0.11    0.06    0.06    0.01    0.15  
PHF1ENSG00000112511  0.00    0.00    0.00    0.01    0.00    0.00    0.01    0.01    0.06    0.04    0.00    0.00    0.02    0.02    0.07    0.01    0.03    0.06    0.02    0.04    0.13    0.06    0.05    0.04    0.03    0.02    0.06    0.01    0.00    0.02    0.06    0.01    0.05    0.03    0.03    0.00    0.00    0.00    0.00    0.00    0.08    0.02    0.26    0.05    0.09    0.01    0.05    0.01    0.05    0.01    0.02    0.07    0.00    0.01    0.00    0.00    0.05    0.03    0.02    0.00    0.01    0.01    0.11    0.00    0.10    0.01  
WISP3ENSG00000112761  0.00    0.04    0.00    0.00    0.00    0.00    0.00    0.28    0.02    0.12    0.00    0.01    0.00    0.14    0.02    0.05    0.05    0.04    0.02    0.03    0.04    0.08    0.05    0.07    0.01    0.03    0.02    0.04    0.00    0.04    0.00    0.08    0.00    0.12    0.10    0.02    0.00    0.00    0.00    0.00    0.12    0.09    0.08    0.25    0.01    0.02    0.06    0.02    0.17    0.02    0.21    0.06    0.00    0.04    0.00    0.00    0.01    0.21    0.01    0.02    0.01    0.07    0.05    0.03    0.01    0.14  

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