Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 287 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| PPM1B | ENSG00000138032 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.06 | 0.06 | 0.00 | 0.00 | 0.00 | 0.01 | 0.05 | 0.07 | 0.01 | 0.15 | 0.02 | 0.03 | 0.01 | 0.03 | 0.03 | 0.03 | 0.02 | 0.00 | 0.02 | 0.01 | 0.02 | 0.01 | 0.02 | 0.05 | 0.02 | 0.00 | 0.05 | 0.02 | 0.03 | 0.00 | 0.01 | 0.00 | 0.00 | 0.05 | 0.02 | 0.27 | 0.05 | 0.07 | 0.00 | 0.08 | 0.02 | 0.20 | 0.02 | 0.05 | 0.05 | 0.12 | 0.01 | 0.00 | 0.00 | 0.10 | 0.02 | 0.01 | 0.00 | 0.00 | 0.01 | 0.03 | 0.00 | 0.00 | 0.01 |
| IDE | ENSG00000119912 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.15 | 0.03 | 0.10 | 0.00 | 0.02 | 0.01 | 0.13 | 0.01 | 0.03 | 0.04 | 0.07 | 0.01 | 0.06 | 0.02 | 0.08 | 0.00 | 0.10 | 0.00 | 0.10 | 0.00 | 0.07 | 0.01 | 0.02 | 0.01 | 0.07 | 0.16 | 0.07 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.08 | 0.06 | 0.33 | 0.01 | 0.07 | 0.03 | 0.10 | 0.03 | 0.13 | 0.01 | 0.06 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.07 | 0.00 | 0.03 | 0.00 | 0.04 | 0.00 | 0.00 | 0.01 | 0.03 |
| GUCY2F | ENSG00000101890 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.03 | 0.04 | 0.00 | 0.00 | 0.01 | 0.03 | 0.01 | 0.14 | 0.01 | 0.05 | 0.01 | 0.09 | 0.02 | 0.07 | 0.01 | 0.02 | 0.01 | 0.02 | 0.01 | 0.01 | 0.01 | 0.02 | 0.01 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.03 | 0.07 | 0.08 | 0.04 | 0.00 | 0.02 | 0.02 | 0.01 | 0.02 | 0.08 | 0.10 | 0.00 | 0.01 | 0.00 | 0.00 | 0.04 | 0.02 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 |
| UMPS | ENSG00000114491 | 0.00 | 0.01 | 0.00 | 0.00 | 0.05 | 0.00 | 0.03 | 0.04 | 0.04 | 0.02 | 0.00 | 0.01 | 0.00 | 0.01 | 0.04 | 0.02 | 0.10 | 0.01 | 0.05 | 0.00 | 0.10 | 0.05 | 0.05 | 0.01 | 0.00 | 0.00 | 0.03 | 0.01 | 0.00 | 0.00 | 0.03 | 0.01 | 0.00 | 0.05 | 0.03 | 0.01 | 0.00 | 0.05 | 0.00 | 0.00 | 0.03 | 0.04 | 0.25 | 0.04 | 0.08 | 0.01 | 0.06 | 0.01 | 0.11 | 0.07 | 0.10 | 0.06 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.01 | 0.02 | 0.01 | 0.06 | 0.00 | 0.00 | 0.00 | 0.04 |
| PI4K2A | ENSG00000155252 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.11 | 0.02 | 0.09 | 0.00 | 0.02 | 0.00 | 0.16 | 0.01 | 0.03 | 0.02 | 0.07 | 0.00 | 0.05 | 0.02 | 0.09 | 0.01 | 0.09 | 0.00 | 0.10 | 0.00 | 0.06 | 0.01 | 0.03 | 0.03 | 0.06 | 0.16 | 0.19 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.01 | 0.03 | 0.08 | 0.08 | 0.33 | 0.01 | 0.07 | 0.03 | 0.10 | 0.04 | 0.09 | 0.03 | 0.06 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.07 | 0.00 | 0.04 | 0.01 | 0.05 | 0.00 | 0.00 | 0.02 | 0.03 |
| APP | ENSG00000142192 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.03 | 0.05 | 0.03 | 0.03 | 0.00 | 0.03 | 0.03 | 0.06 | 0.05 | 0.09 | 0.05 | 0.01 | 0.04 | 0.04 | 0.15 | 0.02 | 0.08 | 0.01 | 0.02 | 0.01 | 0.09 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.01 | 0.13 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.05 | 0.06 | 0.11 | 0.08 | 0.04 | 0.04 | 0.01 | 0.02 | 0.10 | 0.06 | 0.13 | 0.05 | 0.01 | 0.00 | 0.06 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.02 | 0.03 | 0.05 | 0.00 | 0.01 | 0.02 |
| DHRS4 | ENSG00000157326 | 0.00 | 0.00 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.09 | 0.06 | 0.01 | 0.00 | 0.00 | 0.02 | 0.14 | 0.03 | 0.09 | 0.07 | 0.05 | 0.07 | 0.10 | 0.05 | 0.05 | 0.04 | 0.02 | 0.02 | 0.01 | 0.07 | 0.00 | 0.03 | 0.09 | 0.00 | 0.00 | 0.05 | 0.29 | 0.03 | 0.00 | 0.02 | 0.00 | 0.00 | 0.09 | 0.04 | 0.18 | 0.12 | 0.03 | 0.02 | 0.05 | 0.03 | 0.15 | 0.07 | 0.18 | 0.04 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.03 | 0.02 | 0.09 | 0.00 | 0.00 | 0.03 | 0.03 |
| CLEC4M | ENSG00000104938 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.02 | 0.07 | 0.08 | 0.00 | 0.01 | 0.01 | 0.07 | 0.01 | 0.05 | 0.05 | 0.08 | 0.02 | 0.08 | 0.01 | 0.10 | 0.02 | 0.07 | 0.01 | 0.02 | 0.00 | 0.04 | 0.00 | 0.04 | 0.00 | 0.11 | 0.00 | 0.01 | 0.07 | 0.03 | 0.01 | 0.00 | 0.00 | 0.01 | 0.07 | 0.08 | 0.26 | 0.43 | 0.04 | 0.14 | 0.05 | 0.19 | 0.10 | 0.56 | 0.27 | 0.01 | 0.02 | 0.00 | 0.04 | 0.00 | 0.00 | 0.09 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.05 | 0.05 | 0.03 |
| SCYL2 | ENSG00000136021 | 0.01 | 0.01 | 0.02 | 0.01 | 0.06 | 0.02 | 0.05 | 0.03 | 0.06 | 0.03 | 0.00 | 0.00 | 0.01 | 0.03 | 0.02 | 0.05 | 0.01 | 0.04 | 0.02 | 0.02 | 0.04 | 0.05 | 0.04 | 0.04 | 0.01 | 0.02 | 0.01 | 0.03 | 0.00 | 0.06 | 0.04 | 0.04 | 0.00 | 0.22 | 0.00 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.04 | 0.07 | 0.07 | 0.23 | 0.01 | 0.02 | 0.02 | 0.05 | 0.02 | 0.16 | 0.32 | 0.05 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.02 | 0.01 | 0.02 | 0.01 | 0.02 | 0.00 | 0.00 | 0.01 | 0.08 |
| PRMT3 | ENSG00000185238 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.04 | 0.00 | 0.01 | 0.03 | 0.07 | 0.00 | 0.00 | 0.00 | 0.03 | 0.02 | 0.03 | 0.08 | 0.06 | 0.01 | 0.04 | 0.08 | 0.04 | 0.02 | 0.02 | 0.02 | 0.00 | 0.02 | 0.01 | 0.00 | 0.02 | 0.03 | 0.02 | 0.00 | 0.01 | 0.02 | 0.02 | 0.04 | 0.04 | 0.00 | 0.00 | 0.08 | 0.04 | 0.06 | 0.20 | 0.02 | 0.05 | 0.03 | 0.03 | 0.03 | 0.04 | 0.08 | 0.08 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.02 | 0.01 | 0.01 | 0.00 | 0.00 | 0.02 | 0.01 |
| CD82 | ENSG00000085117 | 0.01 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 | 0.00 | 0.08 | 0.03 | 0.06 | 0.00 | 0.01 | 0.00 | 0.01 | 0.04 | 0.01 | 0.08 | 0.03 | 0.12 | 0.02 | 0.19 | 0.03 | 0.05 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.02 | 0.01 | 0.00 | 0.00 | 0.07 | 0.07 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.08 | 0.02 | 0.13 | 0.06 | 0.07 | 0.02 | 0.04 | 0.02 | 0.08 | 0.04 | 0.13 | 0.08 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.02 | 0.00 | 0.05 | 0.00 | 0.02 | 0.02 | 0.04 |
| MAP3K10 | ENSG00000130758 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.02 | 0.01 | 0.03 | 0.23 | 0.02 | 0.00 | 0.00 | 0.08 | 0.02 | 0.17 | 0.03 | 0.47 | 0.05 | 0.07 | 0.02 | 0.05 | 0.05 | 0.07 | 0.02 | 0.06 | 0.01 | 0.01 | 0.01 | 0.25 | 0.00 | 0.08 | 0.02 | 0.12 | 0.01 | 0.15 | 0.04 | 0.00 | 0.02 | 0.00 | 0.00 | 0.13 | 0.03 | 0.54 | 0.18 | 0.20 | 0.04 | 0.19 | 0.03 | 0.93 | 0.11 | 0.25 | 0.11 | 0.00 | 0.03 | 0.01 | 0.00 | 0.05 | 0.00 | 0.02 | 0.06 | 0.03 | 0.05 | 0.00 | 0.00 | 0.03 | 0.01 |
| DPP8 | ENSG00000074603 | 0.01 | 0.00 | 0.00 | 0.00 | 0.14 | 0.00 | 0.00 | 0.02 | 0.02 | 0.04 | 0.00 | 0.00 | 0.08 | 0.00 | 0.03 | 0.02 | 0.04 | 0.03 | 0.02 | 0.02 | 0.04 | 0.02 | 0.03 | 0.02 | 0.01 | 0.01 | 0.01 | 0.02 | 0.03 | 0.02 | 0.03 | 0.01 | 0.00 | 0.01 | 0.04 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.05 | 0.13 | 0.11 | 0.06 | 0.01 | 0.02 | 0.04 | 0.03 | 0.17 | 0.06 | 0.01 | 0.01 | 0.02 | 0.00 | 0.00 | 0.06 | 0.02 | 0.02 | 0.01 | 0.02 | 0.02 | 0.00 | 0.00 | 0.06 | 0.02 |
| P2RX4 | ENSG00000135124 | 0.01 | 0.01 | 0.02 | 0.00 | 0.06 | 0.02 | 0.03 | 0.05 | 0.11 | 0.04 | 0.00 | 0.00 | 0.01 | 0.02 | 0.03 | 0.05 | 0.03 | 0.06 | 0.02 | 0.03 | 0.08 | 0.05 | 0.07 | 0.04 | 0.01 | 0.01 | 0.04 | 0.01 | 0.00 | 0.06 | 0.03 | 0.07 | 0.00 | 0.17 | 0.06 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.04 | 0.08 | 0.14 | 0.22 | 0.01 | 0.02 | 0.02 | 0.07 | 0.09 | 0.22 | 0.12 | 0.06 | 0.01 | 0.00 | 0.00 | 0.00 | 0.10 | 0.03 | 0.03 | 0.01 | 0.01 | 0.01 | 0.07 | 0.00 | 0.04 | 0.06 |
| ATP9A | ENSG00000054793 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.13 | 0.02 | 0.00 | 0.00 | 0.03 | 0.00 | 0.14 | 0.03 | 0.09 | 0.01 | 0.01 | 0.01 | 0.11 | 0.01 | 0.25 | 0.00 | 0.12 | 0.00 | 0.09 | 0.00 | 0.02 | 0.01 | 0.09 | 0.00 | 0.00 | 0.01 | 0.05 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.35 | 0.01 | 0.30 | 0.02 | 0.03 | 0.02 | 0.09 | 0.01 | 0.23 | 0.00 | 0.16 | 0.03 | 0.02 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.13 | 0.00 |
| ABCA9 | ENSG00000154258 | 0.02 | 0.00 | 0.04 | 0.01 | 0.00 | 0.00 | 0.03 | 0.03 | 0.22 | 0.01 | 0.05 | 0.00 | 0.12 | 0.00 | 0.16 | 0.00 | 0.20 | 0.01 | 0.07 | 0.02 | 0.24 | 0.04 | 0.13 | 0.03 | 0.05 | 0.01 | 0.07 | 0.03 | 0.05 | 0.10 | 0.24 | 0.01 | 0.12 | 0.01 | 0.15 | 0.12 | 0.02 | 0.01 | 0.00 | 0.00 | 0.43 | 0.02 | 0.26 | 0.03 | 0.18 | 0.02 | 0.10 | 0.01 | 0.34 | 0.02 | 0.24 | 0.04 | 0.03 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.07 | 0.00 | 0.02 | 0.01 | 0.17 | 0.01 | 0.22 | 0.01 |
| POLB | ENSG00000070501 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.10 | 0.21 | 0.05 | 0.00 | 0.00 | 0.04 | 0.00 | 0.20 | 0.04 | 0.40 | 0.03 | 0.11 | 0.03 | 0.45 | 0.07 | 0.08 | 0.04 | 0.18 | 0.02 | 0.19 | 0.04 | 0.02 | 0.00 | 0.03 | 0.04 | 0.00 | 0.02 | 0.09 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.42 | 0.05 | 0.37 | 0.04 | 0.08 | 0.03 | 0.18 | 0.01 | 0.80 | 0.07 | 0.14 | 0.07 | 0.02 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.05 | 0.02 |
| DHRS4L2 | ENSG00000187630 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.08 | 0.06 | 0.01 | 0.00 | 0.00 | 0.02 | 0.14 | 0.03 | 0.09 | 0.07 | 0.05 | 0.07 | 0.10 | 0.05 | 0.05 | 0.04 | 0.02 | 0.02 | 0.01 | 0.07 | 0.00 | 0.03 | 0.08 | 0.00 | 0.00 | 0.05 | 0.29 | 0.03 | 0.00 | 0.02 | 0.00 | 0.00 | 0.08 | 0.04 | 0.16 | 0.12 | 0.03 | 0.02 | 0.04 | 0.03 | 0.15 | 0.07 | 0.16 | 0.04 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.03 | 0.02 | 0.09 | 0.00 | 0.00 | 0.02 | 0.03 |
| MTMR4 | ENSG00000108389 | 0.01 | 0.00 | 0.05 | 0.00 | 0.00 | 0.00 | 0.02 | 0.05 | 0.18 | 0.02 | 0.02 | 0.00 | 0.11 | 0.00 | 0.10 | 0.00 | 0.14 | 0.02 | 0.05 | 0.02 | 0.15 | 0.05 | 0.06 | 0.04 | 0.04 | 0.01 | 0.07 | 0.05 | 0.03 | 0.15 | 0.18 | 0.01 | 0.12 | 0.01 | 0.14 | 0.03 | 0.02 | 0.00 | 0.00 | 0.00 | 0.51 | 0.01 | 0.18 | 0.03 | 0.10 | 0.03 | 0.08 | 0.04 | 0.23 | 0.02 | 0.18 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.06 | 0.00 | 0.03 | 0.00 | 0.14 | 0.00 | 0.20 | 0.02 |
| BRD7 | ENSG00000166164 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.08 | 0.04 | 0.03 | 0.00 | 0.00 | 0.00 | 0.06 | 0.06 | 0.04 | 0.06 | 0.02 | 0.03 | 0.04 | 0.08 | 0.01 | 0.02 | 0.04 | 0.04 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.00 | 0.13 | 0.06 | 0.04 | 0.00 | 0.03 | 0.00 | 0.00 | 0.05 | 0.06 | 0.07 | 0.14 | 0.02 | 0.06 | 0.02 | 0.05 | 0.05 | 0.14 | 0.02 | 0.13 | 0.08 | 0.01 | 0.02 | 0.00 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.03 | 0.01 | 0.06 |
|
Showing page 287 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.