Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 286 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| MTA3 | ENSG00000057935 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.07 | 0.06 | 0.02 | 0.00 | 0.00 | 0.02 | 0.07 | 0.06 | 0.02 | 0.14 | 0.02 | 0.03 | 0.01 | 0.04 | 0.03 | 0.04 | 0.03 | 0.00 | 0.04 | 0.00 | 0.03 | 0.01 | 0.02 | 0.05 | 0.01 | 0.05 | 0.05 | 0.05 | 0.03 | 0.00 | 0.01 | 0.00 | 0.00 | 0.06 | 0.02 | 0.26 | 0.05 | 0.08 | 0.00 | 0.08 | 0.02 | 0.24 | 0.00 | 0.05 | 0.06 | 0.17 | 0.01 | 0.00 | 0.00 | 0.10 | 0.02 | 0.01 | 0.00 | 0.01 | 0.01 | 0.03 | 0.00 | 0.01 | 0.01 |
| TRIM4 | ENSG00000146833 | 0.01 | 0.00 | 0.06 | 0.00 | 0.00 | 0.00 | 0.04 | 0.02 | 0.08 | 0.01 | 0.00 | 0.00 | 0.03 | 0.03 | 0.13 | 0.02 | 0.24 | 0.01 | 0.24 | 0.00 | 0.52 | 0.02 | 0.33 | 0.01 | 0.02 | 0.01 | 0.02 | 0.00 | 0.11 | 0.01 | 0.09 | 0.01 | 0.11 | 0.01 | 0.10 | 0.03 | 0.01 | 0.02 | 0.00 | 0.00 | 0.07 | 0.03 | 0.21 | 0.05 | 0.07 | 0.01 | 0.08 | 0.02 | 0.15 | 0.03 | 0.07 | 0.04 | 0.09 | 0.01 | 0.00 | 0.00 | 0.13 | 0.00 | 0.06 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | 0.04 | 0.03 |
| STK39 | ENSG00000198648 | 0.02 | 0.00 | 0.05 | 0.00 | 0.00 | 0.00 | 0.01 | 0.09 | 0.07 | 0.05 | 0.00 | 0.01 | 0.00 | 0.00 | 0.07 | 0.01 | 0.09 | 0.02 | 0.08 | 0.01 | 0.14 | 0.02 | 0.06 | 0.04 | 0.01 | 0.01 | 0.01 | 0.02 | 0.02 | 0.01 | 0.05 | 0.05 | 0.00 | 0.01 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.03 | 0.30 | 0.05 | 0.08 | 0.01 | 0.05 | 0.01 | 0.08 | 0.00 | 0.06 | 0.08 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.07 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.02 |
| AGA | ENSG00000038002 | 0.00 | 0.03 | 0.00 | 0.03 | 0.10 | 0.04 | 0.04 | 0.04 | 0.05 | 0.19 | 0.00 | 0.02 | 0.00 | 0.08 | 0.01 | 0.12 | 0.02 | 0.18 | 0.03 | 0.12 | 0.05 | 0.13 | 0.02 | 0.18 | 0.02 | 0.10 | 0.02 | 0.08 | 0.00 | 0.05 | 0.06 | 0.18 | 0.00 | 0.39 | 0.10 | 0.11 | 0.00 | 0.04 | 0.00 | 0.01 | 0.04 | 0.10 | 0.07 | 0.38 | 0.04 | 0.10 | 0.01 | 0.08 | 0.11 | 0.16 | 0.04 | 0.24 | 0.02 | 0.00 | 0.00 | 0.00 | 0.03 | 0.09 | 0.01 | 0.10 | 0.00 | 0.08 | 0.00 | 0.00 | 0.04 | 0.08 |
| NR2F6 | ENSG00000160113 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.04 | 0.00 | 0.03 | 0.05 | 0.01 | 0.01 | 0.02 | 0.08 | 0.03 | 0.04 | 0.02 | 0.13 | 0.01 | 0.04 | 0.02 | 0.02 | 0.00 | 0.01 | 0.03 | 0.01 | 0.01 | 0.06 | 0.02 | 0.04 | 0.03 | 0.14 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.02 | 0.74 | 0.02 | 0.02 | 0.01 | 0.23 | 0.02 | 0.40 | 0.05 | 0.11 | 0.02 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.03 | 0.00 |
| ERBB2IP | ENSG00000112851 | 0.00 | 0.01 | 0.00 | 0.01 | 0.03 | 0.00 | 0.00 | 0.19 | 0.01 | 0.19 | 0.00 | 0.01 | 0.00 | 0.03 | 0.01 | 0.08 | 0.02 | 0.11 | 0.02 | 0.07 | 0.02 | 0.16 | 0.01 | 0.14 | 0.00 | 0.07 | 0.03 | 0.07 | 0.00 | 0.07 | 0.00 | 0.03 | 0.00 | 0.13 | 0.11 | 0.00 | 0.00 | 0.03 | 0.00 | 0.00 | 0.02 | 0.11 | 0.03 | 0.63 | 0.00 | 0.07 | 0.01 | 0.14 | 0.06 | 0.35 | 0.04 | 0.06 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.04 | 0.04 |
| IRAK4 | ENSG00000198001 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.09 | 0.03 | 0.00 | 0.00 | 0.01 | 0.07 | 0.06 | 0.04 | 0.06 | 0.02 | 0.02 | 0.03 | 0.07 | 0.06 | 0.07 | 0.04 | 0.01 | 0.01 | 0.02 | 0.04 | 0.01 | 0.04 | 0.02 | 0.01 | 0.00 | 0.01 | 0.18 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.07 | 0.04 | 0.20 | 0.06 | 0.03 | 0.00 | 0.05 | 0.01 | 0.32 | 0.08 | 0.09 | 0.08 | 0.00 | 0.02 | 0.00 | 0.01 | 0.05 | 0.00 | 0.02 | 0.06 | 0.02 | 0.07 | 0.00 | 0.00 | 0.06 | 0.05 |
| TDRD9 | ENSG00000156414 | 0.00 | 0.02 | 0.01 | 0.01 | 0.00 | 0.04 | 0.02 | 0.03 | 0.06 | 0.07 | 0.00 | 0.00 | 0.00 | 0.08 | 0.06 | 0.06 | 0.19 | 0.04 | 0.07 | 0.05 | 0.08 | 0.07 | 0.04 | 0.07 | 0.00 | 0.03 | 0.03 | 0.02 | 0.02 | 0.03 | 0.01 | 0.13 | 0.00 | 0.31 | 0.14 | 0.00 | 0.01 | 0.03 | 0.00 | 0.00 | 0.07 | 0.07 | 0.29 | 0.17 | 0.07 | 0.09 | 0.09 | 0.02 | 0.16 | 0.02 | 0.17 | 0.05 | 0.03 | 0.01 | 0.00 | 0.00 | 0.02 | 0.07 | 0.00 | 0.07 | 0.03 | 0.05 | 0.03 | 0.03 | 0.01 | 0.06 |
| CST3 | ENSG00000101439 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.05 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.08 | 0.02 | 0.05 | 0.03 | 0.04 | 0.02 | 0.08 | 0.03 | 0.05 | 0.01 | 0.05 | 0.01 | 0.03 | 0.02 | 0.04 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.03 | 0.08 | 0.04 | 0.04 | 0.02 | 0.03 | 0.01 | 0.05 | 0.00 | 0.10 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.00 | 0.03 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.02 |
| ABHD12 | ENSG00000100997 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.02 | 0.04 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.08 | 0.02 | 0.07 | 0.02 | 0.07 | 0.02 | 0.10 | 0.03 | 0.05 | 0.02 | 0.08 | 0.00 | 0.06 | 0.02 | 0.01 | 0.02 | 0.02 | 0.00 | 0.00 | 0.01 | 0.03 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.05 | 0.04 | 0.10 | 0.03 | 0.07 | 0.02 | 0.03 | 0.01 | 0.20 | 0.01 | 0.06 | 0.03 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.02 | 0.01 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.02 | 0.02 |
| LNPEP | ENSG00000113441 | 0.06 | 0.01 | 0.02 | 0.01 | 0.02 | 0.01 | 0.01 | 0.17 | 0.02 | 0.09 | 0.00 | 0.01 | 0.00 | 0.03 | 0.01 | 0.07 | 0.02 | 0.08 | 0.00 | 0.07 | 0.03 | 0.09 | 0.01 | 0.12 | 0.00 | 0.12 | 0.01 | 0.02 | 0.00 | 0.05 | 0.03 | 0.04 | 0.00 | 0.02 | 0.12 | 0.02 | 0.00 | 0.05 | 0.00 | 0.00 | 0.02 | 0.07 | 0.07 | 0.48 | 0.00 | 0.05 | 0.03 | 0.06 | 0.05 | 0.16 | 0.04 | 0.04 | 0.01 | 0.00 | 0.00 | 0.07 | 0.04 | 0.00 | 0.01 | 0.02 | 0.01 | 0.02 | 0.00 | 0.00 | 0.05 | 0.03 |
| RYR3 | ENSG00000198838 | 0.01 | 0.01 | 0.00 | 0.02 | 0.14 | 0.00 | 0.02 | 0.05 | 0.03 | 0.09 | 0.00 | 0.00 | 0.01 | 0.38 | 0.02 | 0.12 | 0.04 | 0.09 | 0.02 | 0.04 | 0.08 | 0.06 | 0.03 | 0.06 | 0.02 | 0.07 | 0.02 | 0.05 | 0.00 | 0.04 | 0.01 | 0.02 | 0.00 | 0.07 | 0.05 | 0.08 | 0.00 | 0.01 | 0.00 | 0.00 | 0.04 | 0.12 | 0.08 | 0.31 | 0.04 | 0.05 | 0.02 | 0.08 | 0.05 | 0.48 | 0.09 | 0.08 | 0.03 | 0.03 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.02 | 0.01 | 0.12 | 0.00 | 0.00 | 0.04 | 0.14 |
| ATP2B4 | ENSG00000058668 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.06 | 0.06 | 0.02 | 0.00 | 0.10 | 0.00 | 0.15 | 0.00 | 0.11 | 0.01 | 0.06 | 0.00 | 0.16 | 0.06 | 0.06 | 0.01 | 0.04 | 0.00 | 0.12 | 0.01 | 0.00 | 0.00 | 0.20 | 0.01 | 0.18 | 0.02 | 0.04 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.32 | 0.07 | 0.06 | 0.00 | 0.12 | 0.01 | 0.27 | 0.00 | 0.14 | 0.12 | 0.05 | 0.00 | 0.01 | 0.00 | 0.26 | 0.02 | 0.17 | 0.01 | 0.38 | 0.01 | 0.09 | 0.00 | 0.19 | 0.01 |
| MAN2A1 | ENSG00000112893 | 0.17 | 0.01 | 0.02 | 0.01 | 0.00 | 0.01 | 0.01 | 0.15 | 0.02 | 0.08 | 0.00 | 0.01 | 0.00 | 0.08 | 0.01 | 0.07 | 0.00 | 0.08 | 0.00 | 0.07 | 0.03 | 0.10 | 0.03 | 0.14 | 0.00 | 0.13 | 0.01 | 0.10 | 0.00 | 0.04 | 0.06 | 0.04 | 0.00 | 0.02 | 0.15 | 0.04 | 0.00 | 0.04 | 0.00 | 0.00 | 0.02 | 0.06 | 0.08 | 0.40 | 0.00 | 0.06 | 0.01 | 0.03 | 0.01 | 0.15 | 0.06 | 0.05 | 0.01 | 0.00 | 0.00 | 0.08 | 0.04 | 0.02 | 0.01 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.06 | 0.05 |
| VWC2 | ENSG00000188730 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.07 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.01 | 0.13 | 0.03 | 0.10 | 0.01 | 0.10 | 0.04 | 0.05 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.01 | 0.00 | 0.06 | 0.01 | 0.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.03 | 0.10 | 0.04 | 0.01 | 0.00 | 0.03 | 0.01 | 0.01 | 0.00 | 0.06 | 0.02 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.05 | 0.02 | 0.00 | 0.08 | 0.01 | 0.00 | 0.00 | 0.02 | 0.03 |
| GABRA5 | ENSG00000186297 | 0.01 | 0.01 | 0.00 | 0.02 | 0.14 | 0.00 | 0.03 | 0.04 | 0.06 | 0.11 | 0.00 | 0.00 | 0.00 | 0.22 | 0.02 | 0.11 | 0.06 | 0.11 | 0.06 | 0.04 | 0.08 | 0.09 | 0.01 | 0.09 | 0.01 | 0.08 | 0.01 | 0.04 | 0.00 | 0.04 | 0.01 | 0.04 | 0.00 | 0.04 | 0.17 | 0.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.12 | 0.07 | 0.29 | 0.03 | 0.05 | 0.02 | 0.06 | 0.07 | 0.43 | 0.09 | 0.10 | 0.04 | 0.03 | 0.04 | 0.00 | 0.00 | 0.04 | 0.00 | 0.02 | 0.01 | 0.06 | 0.00 | 0.00 | 0.04 | 0.10 |
| PAPPA2 | ENSG00000116183 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.03 | 0.29 | 0.01 | 0.02 | 0.00 | 0.09 | 0.03 | 0.12 | 0.01 | 0.20 | 0.01 | 0.03 | 0.01 | 0.18 | 0.02 | 0.10 | 0.01 | 0.03 | 0.00 | 0.13 | 0.00 | 0.05 | 0.00 | 0.19 | 0.01 | 0.17 | 0.01 | 0.00 | 0.04 | 0.02 | 0.00 | 0.00 | 0.00 | 0.17 | 0.01 | 0.36 | 0.03 | 0.10 | 0.00 | 0.09 | 0.01 | 0.26 | 0.00 | 0.31 | 0.03 | 0.08 | 0.00 | 0.00 | 0.00 | 0.29 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.13 | 0.02 |
| PLSCR1 | ENSG00000188313 | 0.03 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.05 | 0.01 | 0.09 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.08 | 0.01 | 0.66 | 0.01 | 0.34 | 0.00 | 0.40 | 0.01 | 0.10 | 0.01 | 0.01 | 0.00 | 0.05 | 0.01 | 0.00 | 0.00 | 0.07 | 0.01 | 0.03 | 0.07 | 0.09 | 0.01 | 0.00 | 0.05 | 0.00 | 0.00 | 0.11 | 0.02 | 0.61 | 0.02 | 0.37 | 0.01 | 0.12 | 0.01 | 0.24 | 0.02 | 0.06 | 0.07 | 0.05 | 0.00 | 0.00 | 0.00 | 0.01 | 0.05 | 0.00 | 0.01 | 0.02 | 0.03 | 0.00 | 0.00 | 0.02 | 0.04 |
| MAPK9 | ENSG00000050748 | 0.33 | 0.01 | 0.06 | 0.01 | 0.00 | 0.04 | 0.05 | 0.01 | 0.02 | 0.10 | 0.00 | 0.01 | 0.03 | 0.05 | 0.10 | 0.03 | 0.04 | 0.05 | 0.03 | 0.06 | 0.17 | 0.01 | 0.03 | 0.04 | 0.03 | 0.01 | 0.04 | 0.03 | 0.03 | 0.01 | 0.15 | 0.05 | 0.05 | 0.01 | 0.37 | 0.03 | 0.01 | 0.03 | 0.01 | 0.00 | 0.10 | 0.04 | 0.23 | 0.14 | 0.03 | 0.04 | 0.08 | 0.03 | 0.15 | 0.02 | 0.18 | 0.09 | 0.00 | 0.01 | 0.00 | 0.02 | 0.02 | 0.03 | 0.01 | 0.06 | 0.02 | 0.04 | 0.04 | 0.02 | 0.09 | 0.08 |
| GRIN3B | ENSG00000116032 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.03 | 0.02 | 0.14 | 0.05 | 0.00 | 0.03 | 0.10 | 0.04 | 0.08 | 0.03 | 0.15 | 0.01 | 0.15 | 0.04 | 0.18 | 0.04 | 0.08 | 0.01 | 0.06 | 0.02 | 0.09 | 0.01 | 0.07 | 0.02 | 0.14 | 0.04 | 0.03 | 0.12 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 | 0.17 | 0.03 | 0.91 | 0.04 | 0.24 | 0.03 | 0.25 | 0.00 | 0.78 | 0.21 | 0.20 | 0.01 | 0.01 | 0.00 | 0.02 | 0.03 | 0.00 | 0.06 | 0.01 | 0.08 | 0.01 | 0.01 | 0.04 | 0.03 | 0.08 |
|
Showing page 286 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.