Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
ASIC1 | ENSG00000110881 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.07 | 0.03 | 0.00 | 0.00 | 0.00 | 0.04 | 0.06 | 0.02 | 0.03 | 0.02 | 0.01 | 0.03 | 0.05 | 0.03 | 0.04 | 0.04 | 0.02 | 0.00 | 0.02 | 0.01 | 0.01 | 0.05 | 0.01 | 0.01 | 0.00 | 0.01 | 0.20 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.03 | 0.05 | 0.11 | 0.06 | 0.03 | 0.01 | 0.05 | 0.01 | 0.27 | 0.06 | 0.07 | 0.09 | 0.02 | 0.00 | 0.00 | 0.01 | 0.10 | 0.03 | 0.00 | 0.04 | 0.05 | 0.04 | 0.00 | 0.00 | 0.04 | 0.06 |
DAO | ENSG00000110887 | 0.01 | 0.01 | 0.02 | 0.00 | 0.06 | 0.02 | 0.04 | 0.03 | 0.10 | 0.03 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.05 | 0.02 | 0.04 | 0.02 | 0.03 | 0.08 | 0.05 | 0.05 | 0.02 | 0.00 | 0.01 | 0.02 | 0.01 | 0.00 | 0.06 | 0.04 | 0.03 | 0.00 | 0.22 | 0.11 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.04 | 0.07 | 0.10 | 0.21 | 0.01 | 0.01 | 0.02 | 0.05 | 0.08 | 0.07 | 0.18 | 0.05 | 0.00 | 0.01 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.04 | 0.01 | 0.02 | 0.00 | 0.00 | 0.02 | 0.07 |
IL23A | ENSG00000110944 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.05 | 0.03 | 0.00 | 0.00 | 0.02 | 0.02 | 0.11 | 0.01 | 0.04 | 0.01 | 0.01 | 0.02 | 0.08 | 0.04 | 0.06 | 0.02 | 0.02 | 0.00 | 0.02 | 0.01 | 0.02 | 0.01 | 0.04 | 0.00 | 0.00 | 0.01 | 0.25 | 0.02 | 0.06 | 0.00 | 0.00 | 0.00 | 0.04 | 0.04 | 0.23 | 0.04 | 0.04 | 0.02 | 0.09 | 0.00 | 0.47 | 0.04 | 0.15 | 0.07 | 0.01 | 0.00 | 0.00 | 0.00 | 0.12 | 0.00 | 0.01 | 0.03 | 0.05 | 0.04 | 0.00 | 0.00 | 0.07 | 0.03 |
ATP5B | ENSG00000110955 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.04 | 0.03 | 0.00 | 0.00 | 0.02 | 0.02 | 0.13 | 0.01 | 0.03 | 0.01 | 0.01 | 0.02 | 0.08 | 0.04 | 0.06 | 0.02 | 0.02 | 0.00 | 0.02 | 0.01 | 0.03 | 0.01 | 0.05 | 0.01 | 0.00 | 0.01 | 0.32 | 0.02 | 0.07 | 0.00 | 0.00 | 0.00 | 0.04 | 0.04 | 0.19 | 0.04 | 0.03 | 0.00 | 0.07 | 0.00 | 0.25 | 0.06 | 0.13 | 0.07 | 0.02 | 0.00 | 0.00 | 0.00 | 0.12 | 0.00 | 0.02 | 0.03 | 0.07 | 0.05 | 0.00 | 0.00 | 0.10 | 0.03 |
SLC6A12 | ENSG00000111181 | 0.02 | 0.00 | 0.00 | 0.01 | 0.04 | 0.02 | 0.01 | 0.06 | 0.12 | 0.04 | 0.01 | 0.00 | 0.04 | 0.01 | 0.11 | 0.07 | 0.23 | 0.02 | 0.19 | 0.01 | 0.26 | 0.04 | 0.11 | 0.06 | 0.14 | 0.01 | 0.15 | 0.03 | 0.14 | 0.04 | 0.04 | 0.05 | 0.30 | 0.08 | 0.06 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.19 | 0.05 | 0.47 | 0.10 | 0.05 | 0.03 | 0.11 | 0.04 | 0.32 | 0.10 | 0.22 | 0.14 | 0.57 | 0.00 | 0.00 | 0.01 | 0.02 | 0.03 | 0.12 | 0.03 | 0.05 | 0.02 | 0.00 | 0.03 | 0.08 | 0.03 |
PRR4 | ENSG00000111215 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.16 | 0.04 | 0.08 | 0.01 | 0.00 | 0.00 | 0.05 | 0.04 | 0.10 | 0.14 | 0.01 | 0.10 | 0.03 | 0.05 | 0.04 | 0.03 | 0.08 | 0.01 | 0.03 | 0.03 | 0.03 | 0.01 | 0.07 | 0.01 | 0.06 | 0.14 | 0.05 | 0.03 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.10 | 0.06 | 0.34 | 0.10 | 0.03 | 0.02 | 0.03 | 0.03 | 0.04 | 0.03 | 0.17 | 0.16 | 0.55 | 0.00 | 0.00 | 0.03 | 0.00 | 0.04 | 0.10 | 0.01 | 0.03 | 0.05 | 0.00 | 0.01 | 0.04 | 0.03 |
KCNA1 | ENSG00000111262 | 0.01 | 0.00 | 0.00 | 0.01 | 0.02 | 0.00 | 0.01 | 0.06 | 0.09 | 0.03 | 0.01 | 0.00 | 0.02 | 0.03 | 0.05 | 0.08 | 0.18 | 0.02 | 0.15 | 0.01 | 0.10 | 0.03 | 0.05 | 0.05 | 0.12 | 0.02 | 0.11 | 0.02 | 0.09 | 0.05 | 0.03 | 0.04 | 0.14 | 0.05 | 0.07 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.12 | 0.04 | 0.34 | 0.08 | 0.05 | 0.02 | 0.07 | 0.02 | 0.21 | 0.02 | 0.20 | 0.12 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.15 | 0.00 | 0.06 | 0.01 | 0.00 | 0.01 | 0.05 | 0.04 |
GPRC5D | ENSG00000111291 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.17 | 0.03 | 0.08 | 0.01 | 0.00 | 0.00 | 0.06 | 0.02 | 0.09 | 0.09 | 0.02 | 0.05 | 0.03 | 0.05 | 0.04 | 0.03 | 0.09 | 0.01 | 0.04 | 0.01 | 0.09 | 0.02 | 0.06 | 0.01 | 0.06 | 0.14 | 0.05 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.06 | 0.07 | 0.25 | 0.12 | 0.01 | 0.02 | 0.03 | 0.03 | 0.04 | 0.03 | 0.11 | 0.16 | 0.54 | 0.00 | 0.00 | 0.06 | 0.00 | 0.13 | 0.03 | 0.03 | 0.00 | 0.06 | 0.00 | 0.01 | 0.04 | 0.03 |
MGP | ENSG00000111341 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.10 | 0.02 | 0.05 | 0.01 | 0.00 | 0.00 | 0.06 | 0.05 | 0.09 | 0.09 | 0.02 | 0.05 | 0.03 | 0.13 | 0.03 | 0.04 | 0.07 | 0.01 | 0.03 | 0.00 | 0.07 | 0.03 | 0.05 | 0.01 | 0.04 | 0.14 | 0.05 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.08 | 0.07 | 0.24 | 0.11 | 0.01 | 0.03 | 0.03 | 0.02 | 0.15 | 0.03 | 0.08 | 0.13 | 0.56 | 0.00 | 0.00 | 0.05 | 0.00 | 0.04 | 0.04 | 0.02 | 0.00 | 0.06 | 0.00 | 0.01 | 0.04 | 0.02 |
ENDOU | ENSG00000111405 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.09 | 0.03 | 0.00 | 0.00 | 0.00 | 0.04 | 0.05 | 0.02 | 0.08 | 0.02 | 0.02 | 0.03 | 0.09 | 0.04 | 0.05 | 0.03 | 0.02 | 0.00 | 0.02 | 0.02 | 0.00 | 0.04 | 0.02 | 0.01 | 0.00 | 0.01 | 0.21 | 0.01 | 0.02 | 0.03 | 0.00 | 0.00 | 0.04 | 0.05 | 0.17 | 0.06 | 0.04 | 0.00 | 0.14 | 0.01 | 0.35 | 0.10 | 0.24 | 0.08 | 0.02 | 0.02 | 0.00 | 0.03 | 0.13 | 0.04 | 0.01 | 0.05 | 0.01 | 0.06 | 0.00 | 0.00 | 0.05 | 0.05 |
FZD10 | ENSG00000111432 | 0.01 | 0.01 | 0.03 | 0.01 | 0.07 | 0.02 | 0.02 | 0.08 | 0.08 | 0.07 | 0.00 | 0.00 | 0.01 | 0.05 | 0.05 | 0.06 | 0.04 | 0.07 | 0.03 | 0.05 | 0.09 | 0.07 | 0.06 | 0.05 | 0.02 | 0.01 | 0.05 | 0.02 | 0.00 | 0.07 | 0.04 | 0.12 | 0.00 | 0.17 | 0.05 | 0.02 | 0.03 | 0.04 | 0.00 | 0.00 | 0.03 | 0.09 | 0.15 | 0.27 | 0.04 | 0.01 | 0.03 | 0.07 | 0.04 | 0.16 | 0.15 | 0.09 | 0.01 | 0.01 | 0.00 | 0.00 | 0.07 | 0.00 | 0.04 | 0.02 | 0.01 | 0.05 | 0.00 | 0.00 | 0.03 | 0.09 |
ADGRD1 | ENSG00000111452 | 0.01 | 0.01 | 0.03 | 0.00 | 0.07 | 0.02 | 0.02 | 0.07 | 0.08 | 0.06 | 0.00 | 0.00 | 0.04 | 0.03 | 0.04 | 0.06 | 0.05 | 0.07 | 0.03 | 0.05 | 0.10 | 0.06 | 0.06 | 0.04 | 0.02 | 0.01 | 0.05 | 0.02 | 0.00 | 0.06 | 0.04 | 0.11 | 0.00 | 0.17 | 0.05 | 0.02 | 0.03 | 0.04 | 0.00 | 0.00 | 0.04 | 0.08 | 0.14 | 0.27 | 0.04 | 0.02 | 0.02 | 0.06 | 0.04 | 0.16 | 0.19 | 0.08 | 0.01 | 0.01 | 0.00 | 0.00 | 0.07 | 0.00 | 0.04 | 0.02 | 0.03 | 0.03 | 0.00 | 0.00 | 0.03 | 0.09 |
IL26 | ENSG00000111536 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.02 | 0.32 | 0.02 | 0.00 | 0.02 | 0.03 | 0.01 | 0.30 | 0.01 | 0.24 | 0.01 | 0.27 | 0.02 | 0.33 | 0.02 | 0.36 | 0.02 | 0.00 | 0.01 | 0.03 | 0.06 | 0.11 | 0.02 | 0.04 | 0.00 | 0.24 | 0.02 | 0.34 | 0.05 | 0.05 | 0.01 | 0.00 | 0.00 | 0.24 | 0.02 | 0.21 | 0.04 | 0.07 | 0.01 | 0.03 | 0.01 | 0.31 | 0.07 | 0.77 | 0.05 | 0.14 | 0.00 | 0.00 | 0.01 | 0.12 | 0.00 | 0.02 | 0.02 | 0.15 | 0.07 | 0.00 | 0.00 | 0.16 | 0.01 |
IFNG | ENSG00000111537 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.02 | 0.33 | 0.02 | 0.00 | 0.02 | 0.03 | 0.01 | 0.30 | 0.01 | 0.24 | 0.01 | 0.27 | 0.02 | 0.35 | 0.02 | 0.35 | 0.01 | 0.00 | 0.01 | 0.03 | 0.06 | 0.11 | 0.02 | 0.04 | 0.00 | 0.04 | 0.02 | 0.33 | 0.05 | 0.05 | 0.01 | 0.00 | 0.00 | 0.22 | 0.02 | 0.22 | 0.04 | 0.07 | 0.01 | 0.03 | 0.01 | 0.31 | 0.07 | 0.73 | 0.05 | 0.14 | 0.00 | 0.00 | 0.01 | 0.12 | 0.00 | 0.02 | 0.02 | 0.19 | 0.07 | 0.00 | 0.00 | 0.17 | 0.01 |
LPCAT3 | ENSG00000111684 | 0.01 | 0.00 | 0.00 | 0.01 | 0.02 | 0.00 | 0.01 | 0.07 | 0.09 | 0.02 | 0.01 | 0.00 | 0.00 | 0.08 | 0.07 | 0.07 | 0.18 | 0.01 | 0.11 | 0.02 | 0.07 | 0.02 | 0.06 | 0.05 | 0.06 | 0.02 | 0.04 | 0.03 | 0.06 | 0.05 | 0.05 | 0.04 | 0.18 | 0.05 | 0.09 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.13 | 0.04 | 0.35 | 0.08 | 0.04 | 0.02 | 0.09 | 0.02 | 0.17 | 0.03 | 0.08 | 0.11 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.14 | 0.01 | 0.06 | 0.02 | 0.00 | 0.01 | 0.04 | 0.04 |
SLCO1B3 | ENSG00000111700 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.02 | 0.06 | 0.05 | 0.04 | 0.01 | 0.00 | 0.00 | 0.04 | 0.17 | 0.05 | 0.17 | 0.01 | 0.07 | 0.02 | 0.14 | 0.03 | 0.12 | 0.03 | 0.02 | 0.02 | 0.11 | 0.03 | 0.07 | 0.05 | 0.00 | 0.04 | 0.14 | 0.07 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.04 | 0.31 | 0.08 | 0.01 | 0.01 | 0.04 | 0.02 | 0.15 | 0.03 | 0.18 | 0.10 | 0.59 | 0.00 | 0.01 | 0.01 | 0.00 | 0.04 | 0.06 | 0.01 | 0.03 | 0.04 | 0.00 | 0.00 | 0.06 | 0.01 |
PRKAB1 | ENSG00000111725 | 0.01 | 0.01 | 0.02 | 0.00 | 0.06 | 0.02 | 0.04 | 0.03 | 0.09 | 0.04 | 0.00 | 0.00 | 0.01 | 0.03 | 0.03 | 0.05 | 0.03 | 0.06 | 0.03 | 0.02 | 0.08 | 0.05 | 0.05 | 0.02 | 0.00 | 0.01 | 0.04 | 0.02 | 0.00 | 0.06 | 0.03 | 0.06 | 0.00 | 0.17 | 0.04 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.04 | 0.08 | 0.14 | 0.21 | 0.01 | 0.02 | 0.02 | 0.05 | 0.09 | 0.08 | 0.17 | 0.04 | 0.01 | 0.00 | 0.00 | 0.01 | 0.10 | 0.00 | 0.03 | 0.01 | 0.01 | 0.01 | 0.07 | 0.00 | 0.02 | 0.06 |
RAB35 | ENSG00000111737 | 0.01 | 0.01 | 0.02 | 0.00 | 0.06 | 0.02 | 0.04 | 0.03 | 0.11 | 0.04 | 0.00 | 0.00 | 0.01 | 0.02 | 0.03 | 0.05 | 0.03 | 0.05 | 0.03 | 0.02 | 0.07 | 0.05 | 0.06 | 0.02 | 0.00 | 0.01 | 0.04 | 0.02 | 0.00 | 0.06 | 0.03 | 0.06 | 0.00 | 0.17 | 0.13 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.04 | 0.08 | 0.13 | 0.21 | 0.01 | 0.02 | 0.04 | 0.05 | 0.14 | 0.08 | 0.13 | 0.04 | 0.01 | 0.00 | 0.00 | 0.00 | 0.10 | 0.00 | 0.03 | 0.01 | 0.01 | 0.00 | 0.07 | 0.00 | 0.03 | 0.06 |
KLRB1 | ENSG00000111796 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.10 | 0.07 | 0.05 | 0.01 | 0.00 | 0.00 | 0.05 | 0.04 | 0.09 | 0.12 | 0.01 | 0.10 | 0.03 | 0.07 | 0.02 | 0.07 | 0.09 | 0.02 | 0.03 | 0.04 | 0.03 | 0.00 | 0.07 | 0.01 | 0.05 | 0.14 | 0.05 | 0.03 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.09 | 0.05 | 0.31 | 0.09 | 0.03 | 0.03 | 0.03 | 0.03 | 0.16 | 0.03 | 0.06 | 0.12 | 0.55 | 0.00 | 0.00 | 0.01 | 0.00 | 0.12 | 0.11 | 0.01 | 0.03 | 0.05 | 0.00 | 0.01 | 0.05 | 0.04 |
BTN3A3 | ENSG00000111801 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.02 | 0.21 | 0.03 | 0.00 | 0.01 | 0.02 | 0.05 | 0.08 | 0.01 | 0.07 | 0.06 | 0.02 | 0.04 | 0.11 | 0.10 | 0.06 | 0.05 | 0.03 | 0.02 | 0.05 | 0.03 | 0.02 | 0.04 | 0.10 | 0.01 | 0.06 | 0.08 | 0.04 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.11 | 0.03 | 0.35 | 0.05 | 0.09 | 0.03 | 0.04 | 0.01 | 0.20 | 0.02 | 0.04 | 0.06 | 0.01 | 0.01 | 0.00 | 0.00 | 0.05 | 0.01 | 0.01 | 0.01 | 0.01 | 0.00 | 0.11 | 0.00 | 0.13 | 0.01 |
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