Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 278 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| GDF11 | ENSG00000135414 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.04 | 0.02 | 0.00 | 0.00 | 0.02 | 0.02 | 0.08 | 0.01 | 0.04 | 0.02 | 0.01 | 0.02 | 0.07 | 0.03 | 0.10 | 0.02 | 0.02 | 0.00 | 0.02 | 0.01 | 0.02 | 0.01 | 0.03 | 0.00 | 0.00 | 0.01 | 0.18 | 0.02 | 0.06 | 0.00 | 0.00 | 0.00 | 0.04 | 0.05 | 0.19 | 0.04 | 0.03 | 0.00 | 0.08 | 0.01 | 0.14 | 0.07 | 0.27 | 0.07 | 0.01 | 0.00 | 0.00 | 0.00 | 0.12 | 0.00 | 0.01 | 0.03 | 0.04 | 0.05 | 0.00 | 0.00 | 0.06 | 0.03 |
| SRPK1 | ENSG00000096063 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 | 0.08 | 0.04 | 0.00 | 0.00 | 0.02 | 0.01 | 0.08 | 0.01 | 0.04 | 0.05 | 0.03 | 0.03 | 0.14 | 0.04 | 0.07 | 0.03 | 0.03 | 0.01 | 0.06 | 0.01 | 0.05 | 0.01 | 0.05 | 0.02 | 0.05 | 0.03 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.07 | 0.03 | 0.25 | 0.05 | 0.08 | 0.00 | 0.05 | 0.01 | 0.22 | 0.07 | 0.13 | 0.08 | 0.05 | 0.01 | 0.00 | 0.00 | 0.08 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.10 | 0.00 | 0.09 | 0.01 |
| KLHL5 | ENSG00000109790 | 0.00 | 0.00 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.04 | 0.02 | 0.04 | 0.00 | 0.00 | 0.00 | 0.02 | 0.08 | 0.02 | 0.04 | 0.04 | 0.04 | 0.01 | 0.04 | 0.05 | 0.01 | 0.02 | 0.01 | 0.01 | 0.02 | 0.03 | 0.02 | 0.00 | 0.07 | 0.01 | 0.04 | 0.07 | 0.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.03 | 0.06 | 0.07 | 0.03 | 0.01 | 0.02 | 0.02 | 0.10 | 0.11 | 0.11 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.05 | 0.00 | 0.04 | 0.00 |
| MTCH2 | ENSG00000109919 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.00 | 0.08 | 0.03 | 0.05 | 0.00 | 0.00 | 0.00 | 0.01 | 0.04 | 0.02 | 0.10 | 0.04 | 0.06 | 0.01 | 0.07 | 0.04 | 0.04 | 0.01 | 0.01 | 0.01 | 0.01 | 0.00 | 0.03 | 0.01 | 0.03 | 0.00 | 0.00 | 0.07 | 0.08 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.07 | 0.03 | 0.11 | 0.06 | 0.06 | 0.03 | 0.04 | 0.03 | 0.13 | 0.07 | 0.09 | 0.07 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.04 | 0.00 | 0.02 | 0.01 | 0.05 |
| CPT2 | ENSG00000157184 | 0.00 | 0.01 | 0.02 | 0.01 | 0.00 | 0.00 | 0.01 | 0.05 | 0.09 | 0.04 | 0.00 | 0.00 | 0.06 | 0.04 | 0.08 | 0.04 | 0.06 | 0.03 | 0.04 | 0.03 | 0.04 | 0.03 | 0.03 | 0.04 | 0.01 | 0.04 | 0.02 | 0.04 | 0.01 | 0.01 | 0.03 | 0.06 | 0.00 | 0.25 | 0.02 | 0.03 | 0.00 | 0.17 | 0.00 | 0.00 | 0.07 | 0.05 | 0.30 | 0.10 | 0.08 | 0.02 | 0.05 | 0.02 | 0.04 | 0.04 | 0.22 | 0.03 | 0.07 | 0.04 | 0.02 | 0.00 | 0.00 | 0.07 | 0.00 | 0.01 | 0.02 | 0.02 | 0.00 | 0.07 | 0.04 | 0.02 |
| CPQ | ENSG00000104324 | 0.00 | 0.00 | 0.01 | 0.00 | 0.14 | 0.00 | 0.09 | 0.01 | 0.32 | 0.01 | 0.02 | 0.00 | 0.02 | 0.01 | 0.18 | 0.01 | 0.19 | 0.02 | 0.11 | 0.00 | 0.23 | 0.03 | 0.16 | 0.01 | 0.08 | 0.00 | 0.17 | 0.01 | 0.04 | 0.01 | 0.28 | 0.00 | 0.25 | 0.01 | 0.04 | 0.00 | 0.00 | 0.03 | 0.00 | 0.00 | 0.38 | 0.00 | 0.54 | 0.07 | 0.11 | 0.00 | 0.12 | 0.02 | 0.41 | 0.02 | 0.18 | 0.04 | 0.15 | 0.00 | 0.00 | 0.00 | 0.08 | 0.04 | 0.13 | 0.00 | 0.01 | 0.00 | 0.39 | 0.00 | 0.12 | 0.01 |
| CBR4 | ENSG00000145439 | 0.00 | 0.02 | 0.00 | 0.03 | 0.06 | 0.02 | 0.04 | 0.03 | 0.05 | 0.14 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.09 | 0.02 | 0.17 | 0.03 | 0.09 | 0.10 | 0.07 | 0.08 | 0.10 | 0.04 | 0.07 | 0.02 | 0.05 | 0.00 | 0.04 | 0.08 | 0.11 | 0.00 | 0.17 | 0.12 | 0.07 | 0.00 | 0.03 | 0.00 | 0.00 | 0.05 | 0.08 | 0.10 | 0.31 | 0.05 | 0.10 | 0.04 | 0.06 | 0.12 | 0.05 | 0.10 | 0.18 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.06 | 0.01 | 0.10 | 0.00 | 0.06 | 0.00 | 0.00 | 0.06 | 0.05 |
| PARP12 | ENSG00000059378 | 0.02 | 0.01 | 0.05 | 0.00 | 0.05 | 0.02 | 0.03 | 0.02 | 0.04 | 0.04 | 0.00 | 0.01 | 0.04 | 0.05 | 0.08 | 0.02 | 0.09 | 0.06 | 0.03 | 0.14 | 0.04 | 0.19 | 0.04 | 0.08 | 0.03 | 0.00 | 0.03 | 0.02 | 0.04 | 0.04 | 0.05 | 0.04 | 0.00 | 0.06 | 0.06 | 0.06 | 0.00 | 0.01 | 0.00 | 0.00 | 0.10 | 0.04 | 0.52 | 0.04 | 0.03 | 0.08 | 0.07 | 0.05 | 0.14 | 0.14 | 0.10 | 0.08 | 0.02 | 0.04 | 0.00 | 0.05 | 0.02 | 0.09 | 0.12 | 0.00 | 0.05 | 0.01 | 0.00 | 0.00 | 0.24 | 0.02 |
| KDM6B | ENSG00000132510 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.25 | 0.02 | 0.03 | 0.00 | 0.01 | 0.00 | 0.03 | 0.01 | 0.05 | 0.01 | 0.03 | 0.01 | 0.04 | 0.03 | 0.04 | 0.01 | 0.03 | 0.00 | 0.02 | 0.00 | 0.03 | 0.01 | 0.02 | 0.01 | 0.16 | 0.02 | 0.12 | 0.02 | 0.05 | 0.00 | 0.03 | 0.00 | 0.00 | 0.02 | 0.06 | 0.08 | 0.05 | 0.00 | 0.04 | 0.03 | 0.04 | 0.06 | 0.15 | 0.15 | 0.35 | 0.00 | 0.02 | 0.02 | 0.01 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 | 0.00 | 0.00 | 0.05 |
| IGFBP4 | ENSG00000141753 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.12 | 0.02 | 0.00 | 0.01 | 0.01 | 0.04 | 0.09 | 0.01 | 0.11 | 0.04 | 0.07 | 0.01 | 0.64 | 0.03 | 0.60 | 0.01 | 0.14 | 0.00 | 0.15 | 0.00 | 0.04 | 0.03 | 0.02 | 0.03 | 0.02 | 0.01 | 0.01 | 0.17 | 0.00 | 0.11 | 0.00 | 0.00 | 0.28 | 0.09 | 0.04 | 0.16 | 0.05 | 0.04 | 0.08 | 0.07 | 0.28 | 0.09 | 0.06 | 0.13 | 0.01 | 0.01 | 0.00 | 0.02 | 0.04 | 0.00 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.05 | 0.02 | 0.03 |
| STK38L | ENSG00000211455 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.03 | 0.11 | 0.03 | 0.00 | 0.00 | 0.04 | 0.01 | 0.22 | 0.03 | 0.18 | 0.01 | 0.05 | 0.01 | 0.38 | 0.04 | 0.20 | 0.02 | 0.04 | 0.01 | 0.09 | 0.04 | 0.07 | 0.02 | 0.04 | 0.02 | 0.04 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.12 | 0.03 | 0.40 | 0.04 | 0.04 | 0.01 | 0.08 | 0.02 | 0.33 | 0.03 | 0.17 | 0.07 | 0.57 | 0.00 | 0.00 | 0.01 | 0.00 | 0.05 | 0.04 | 0.00 | 0.03 | 0.01 | 0.00 | 0.00 | 0.04 | 0.01 |
| DNPEP | ENSG00000123992 | 0.01 | 0.07 | 0.04 | 0.04 | 0.00 | 0.03 | 0.01 | 0.03 | 0.01 | 0.27 | 0.00 | 0.02 | 0.00 | 0.10 | 0.02 | 0.03 | 0.04 | 0.19 | 0.00 | 0.18 | 0.04 | 0.13 | 0.05 | 0.04 | 0.02 | 0.01 | 0.02 | 0.02 | 0.05 | 0.03 | 0.03 | 0.04 | 0.00 | 0.04 | 0.03 | 0.03 | 0.02 | 0.00 | 0.00 | 0.01 | 0.04 | 0.06 | 0.17 | 0.16 | 0.03 | 0.34 | 0.05 | 0.04 | 0.08 | 0.05 | 0.09 | 0.20 | 0.08 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.02 | 0.00 | 0.01 | 0.02 | 0.02 | 0.02 | 0.04 |
| SLC5A4 | ENSG00000100191 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.16 | 0.01 | 0.02 | 0.03 | 0.00 | 0.01 | 0.04 | 0.02 | 0.12 | 0.01 | 0.02 | 0.00 | 0.05 | 0.01 | 0.01 | 0.01 | 0.02 | 0.01 | 0.02 | 0.01 | 0.00 | 0.02 | 0.02 | 0.02 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.00 | 0.03 | 0.03 | 0.18 | 0.06 | 0.03 | 0.00 | 0.07 | 0.03 | 0.20 | 0.07 | 0.08 | 0.03 | 0.05 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.04 | 0.00 | 0.00 | 0.05 | 0.03 |
| CRIM1 | ENSG00000150938 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.05 | 0.06 | 0.01 | 0.00 | 0.01 | 0.01 | 0.06 | 0.06 | 0.01 | 0.08 | 0.02 | 0.03 | 0.02 | 0.03 | 0.03 | 0.02 | 0.03 | 0.00 | 0.01 | 0.00 | 0.05 | 0.01 | 0.03 | 0.05 | 0.00 | 0.00 | 0.07 | 0.00 | 0.04 | 0.00 | 0.01 | 0.00 | 0.00 | 0.05 | 0.02 | 0.21 | 0.06 | 0.08 | 0.00 | 0.08 | 0.02 | 0.21 | 0.00 | 0.11 | 0.06 | 0.13 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.01 | 0.03 | 0.00 | 0.01 | 0.01 |
| ENTPD6 | ENSG00000197586 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.02 | 0.04 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.07 | 0.02 | 0.06 | 0.02 | 0.06 | 0.02 | 0.10 | 0.03 | 0.05 | 0.02 | 0.06 | 0.00 | 0.07 | 0.02 | 0.02 | 0.01 | 0.02 | 0.00 | 0.06 | 0.01 | 0.03 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.05 | 0.04 | 0.10 | 0.03 | 0.06 | 0.02 | 0.03 | 0.01 | 0.20 | 0.01 | 0.06 | 0.03 | 0.02 | 0.00 | 0.01 | 0.00 | 0.04 | 0.02 | 0.00 | 0.02 | 0.02 | 0.01 | 0.02 | 0.00 | 0.01 | 0.02 |
| ADCY9 | ENSG00000162104 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.01 | 0.18 | 0.00 | 0.00 | 0.04 | 0.02 | 0.04 | 0.03 | 0.04 | 0.09 | 0.04 | 0.02 | 0.02 | 0.07 | 0.03 | 0.08 | 0.04 | 0.03 | 0.02 | 0.03 | 0.02 | 0.02 | 0.04 | 0.02 | 0.05 | 0.05 | 0.14 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.11 | 0.02 | 0.12 | 0.20 | 0.12 | 0.02 | 0.05 | 0.04 | 0.00 | 0.10 | 0.09 | 0.05 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.03 | 0.01 | 0.03 | 0.01 | 0.00 | 0.00 | 0.07 | 0.02 |
| SRC | ENSG00000197122 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.03 | 0.07 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.02 | 0.11 | 0.01 | 0.04 | 0.01 | 0.10 | 0.01 | 0.08 | 0.00 | 0.07 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.04 | 0.03 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.10 | 0.02 | 0.10 | 0.06 | 0.05 | 0.01 | 0.06 | 0.01 | 0.14 | 0.00 | 0.07 | 0.05 | 0.00 | 0.01 | 0.00 | 0.03 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 |
| RSPO2 | ENSG00000147655 | 0.01 | 0.01 | 0.01 | 0.00 | 0.20 | 0.00 | 0.08 | 0.02 | 0.30 | 0.01 | 0.02 | 0.00 | 0.02 | 0.03 | 0.18 | 0.01 | 0.30 | 0.01 | 0.17 | 0.00 | 0.34 | 0.00 | 0.20 | 0.01 | 0.14 | 0.00 | 0.18 | 0.00 | 0.06 | 0.01 | 0.34 | 0.00 | 0.25 | 0.03 | 0.04 | 0.00 | 0.01 | 0.03 | 0.00 | 0.00 | 0.45 | 0.01 | 0.89 | 0.06 | 0.14 | 0.00 | 0.15 | 0.01 | 0.32 | 0.00 | 0.13 | 0.06 | 0.06 | 0.00 | 0.00 | 0.00 | 0.08 | 0.00 | 0.17 | 0.00 | 0.02 | 0.01 | 0.43 | 0.00 | 0.14 | 0.02 |
| SLC25A43 | ENSG00000077713 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.03 | 0.04 | 0.03 | 0.00 | 0.03 | 0.01 | 0.09 | 0.01 | 0.11 | 0.01 | 0.05 | 0.01 | 0.10 | 0.02 | 0.07 | 0.01 | 0.03 | 0.01 | 0.02 | 0.02 | 0.01 | 0.00 | 0.11 | 0.02 | 0.03 | 0.01 | 0.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.02 | 0.18 | 0.03 | 0.06 | 0.01 | 0.02 | 0.01 | 0.01 | 0.05 | 0.03 | 0.10 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.02 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.02 |
| CRYZ | ENSG00000116791 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.07 | 0.10 | 0.05 | 0.00 | 0.00 | 0.00 | 0.20 | 0.03 | 0.06 | 0.06 | 0.06 | 0.01 | 0.05 | 0.01 | 0.09 | 0.02 | 0.05 | 0.00 | 0.08 | 0.01 | 0.06 | 0.00 | 0.01 | 0.01 | 0.04 | 0.00 | 0.08 | 0.05 | 0.02 | 0.00 | 0.19 | 0.00 | 0.00 | 0.04 | 0.07 | 0.11 | 0.16 | 0.03 | 0.03 | 0.01 | 0.02 | 0.07 | 0.06 | 0.19 | 0.02 | 0.03 | 0.03 | 0.02 | 0.01 | 0.00 | 0.03 | 0.00 | 0.01 | 0.01 | 0.03 | 0.03 | 0.05 | 0.05 | 0.07 |
|
Showing page 278 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.