Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 275 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| CA5A | ENSG00000174990 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.06 | 0.01 | 0.25 | 0.09 | 0.04 | 0.00 | 0.00 | 0.00 | 0.17 | 0.01 | 0.11 | 0.02 | 0.06 | 0.03 | 0.04 | 0.07 | 0.05 | 0.04 | 0.04 | 0.02 | 0.03 | 0.07 | 0.03 | 0.02 | 0.01 | 0.02 | 0.08 | 0.05 | 0.05 | 0.27 | 0.05 | 0.00 | 0.02 | 0.00 | 0.01 | 0.05 | 0.08 | 0.04 | 0.33 | 0.05 | 0.07 | 0.02 | 0.09 | 0.00 | 0.28 | 0.05 | 0.09 | 0.00 | 0.11 | 0.00 | 0.04 | 0.03 | 0.03 | 0.00 | 0.02 | 0.01 | 0.04 | 0.00 | 0.02 | 0.02 | 0.10 |
| DYRK2 | ENSG00000127334 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.02 | 0.35 | 0.02 | 0.00 | 0.00 | 0.03 | 0.01 | 0.28 | 0.01 | 0.25 | 0.02 | 0.27 | 0.02 | 0.36 | 0.01 | 0.25 | 0.01 | 0.00 | 0.01 | 0.01 | 0.04 | 0.06 | 0.01 | 0.03 | 0.00 | 0.04 | 0.01 | 0.39 | 0.02 | 0.05 | 0.01 | 0.00 | 0.00 | 0.22 | 0.02 | 0.22 | 0.04 | 0.06 | 0.00 | 0.04 | 0.01 | 0.41 | 0.07 | 0.93 | 0.06 | 0.07 | 0.00 | 0.00 | 0.00 | 0.12 | 0.00 | 0.02 | 0.02 | 0.10 | 0.07 | 0.00 | 0.00 | 0.18 | 0.02 |
| PHF19 | ENSG00000119403 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.02 | 0.02 | 0.04 | 0.00 | 0.01 | 0.01 | 0.01 | 0.05 | 0.03 | 0.06 | 0.01 | 0.05 | 0.01 | 0.11 | 0.03 | 0.08 | 0.02 | 0.01 | 0.01 | 0.05 | 0.02 | 0.00 | 0.01 | 0.04 | 0.04 | 0.06 | 0.04 | 0.08 | 0.02 | 0.03 | 0.00 | 0.00 | 0.00 | 0.05 | 0.04 | 0.10 | 0.13 | 0.02 | 0.01 | 0.02 | 0.04 | 0.00 | 0.15 | 0.06 | 0.04 | 0.03 | 0.02 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.01 | 0.04 | 0.02 | 0.00 | 0.00 | 0.02 | 0.01 |
| B4GALT1 | ENSG00000086062 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.02 | 0.08 | 0.03 | 0.00 | 0.00 | 0.01 | 0.08 | 0.06 | 0.02 | 0.36 | 0.04 | 0.14 | 0.03 | 0.21 | 0.03 | 0.15 | 0.03 | 0.01 | 0.00 | 0.01 | 0.00 | 0.04 | 0.00 | 0.02 | 0.01 | 0.24 | 0.01 | 0.14 | 0.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.03 | 0.11 | 0.08 | 0.02 | 0.02 | 0.06 | 0.02 | 0.11 | 0.05 | 0.10 | 0.04 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.04 | 0.07 | 0.00 | 0.00 | 0.05 | 0.05 |
| RHBDD1 | ENSG00000144468 | 0.01 | 0.07 | 0.04 | 0.04 | 0.00 | 0.05 | 0.01 | 0.03 | 0.01 | 0.31 | 0.00 | 0.02 | 0.00 | 0.10 | 0.03 | 0.04 | 0.01 | 0.19 | 0.01 | 0.18 | 0.06 | 0.14 | 0.05 | 0.04 | 0.02 | 0.03 | 0.02 | 0.02 | 0.07 | 0.01 | 0.04 | 0.05 | 0.00 | 0.04 | 0.03 | 0.04 | 0.00 | 0.01 | 0.00 | 0.01 | 0.03 | 0.08 | 0.15 | 0.19 | 0.01 | 0.37 | 0.03 | 0.05 | 0.16 | 0.06 | 0.10 | 0.23 | 0.06 | 0.02 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.03 | 0.00 | 0.01 | 0.02 | 0.05 | 0.03 | 0.06 |
| SETD5 | ENSG00000168137 | 0.00 | 0.18 | 0.00 | 0.01 | 0.07 | 0.00 | 0.02 | 0.06 | 0.43 | 0.02 | 0.00 | 0.03 | 0.03 | 0.12 | 0.03 | 0.04 | 0.03 | 0.04 | 0.04 | 0.03 | 0.08 | 0.04 | 0.08 | 0.08 | 0.00 | 0.04 | 0.01 | 0.06 | 0.01 | 0.02 | 0.06 | 0.01 | 0.00 | 0.18 | 0.07 | 0.01 | 0.00 | 0.04 | 0.00 | 0.00 | 0.12 | 0.03 | 0.17 | 0.24 | 0.02 | 0.02 | 0.08 | 0.03 | 0.09 | 0.20 | 0.22 | 0.05 | 0.05 | 0.05 | 0.00 | 0.00 | 0.00 | 0.05 | 0.03 | 0.01 | 0.04 | 0.02 | 0.00 | 0.00 | 0.02 | 0.06 |
| STK32B | ENSG00000152953 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.03 | 0.07 | 0.04 | 0.00 | 0.00 | 0.00 | 0.03 | 0.04 | 0.04 | 0.04 | 0.04 | 0.03 | 0.07 | 0.04 | 0.08 | 0.05 | 0.05 | 0.02 | 0.03 | 0.03 | 0.03 | 0.03 | 0.01 | 0.04 | 0.05 | 0.00 | 0.01 | 0.08 | 0.03 | 0.00 | 0.00 | 0.01 | 0.00 | 0.03 | 0.05 | 0.25 | 0.08 | 0.02 | 0.06 | 0.06 | 0.04 | 0.12 | 0.00 | 0.14 | 0.06 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.00 | 0.01 | 0.02 | 0.02 | 0.00 | 0.04 | 0.05 |
| DPP9 | ENSG00000142002 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.04 | 0.01 | 0.03 | 0.04 | 0.11 | 0.00 | 0.01 | 0.01 | 0.10 | 0.01 | 0.07 | 0.04 | 0.10 | 0.03 | 0.11 | 0.04 | 0.12 | 0.00 | 0.08 | 0.01 | 0.05 | 0.06 | 0.09 | 0.00 | 0.06 | 0.03 | 0.13 | 0.00 | 0.03 | 0.04 | 0.03 | 0.01 | 0.00 | 0.00 | 0.01 | 0.05 | 0.10 | 0.05 | 0.75 | 0.05 | 0.17 | 0.01 | 0.25 | 0.08 | 0.67 | 0.15 | 0.07 | 0.00 | 0.00 | 0.04 | 0.00 | 0.00 | 0.03 | 0.01 | 0.01 | 0.04 | 0.01 | 0.00 | 0.05 | 0.04 | 0.03 |
| XIAP | ENSG00000101966 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.07 | 0.03 | 0.04 | 0.01 | 0.03 | 0.02 | 0.09 | 0.02 | 0.08 | 0.02 | 0.08 | 0.01 | 0.13 | 0.02 | 0.12 | 0.01 | 0.03 | 0.00 | 0.04 | 0.02 | 0.01 | 0.00 | 0.08 | 0.02 | 0.00 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.02 | 0.21 | 0.03 | 0.07 | 0.01 | 0.02 | 0.01 | 0.01 | 0.08 | 0.05 | 0.10 | 0.00 | 0.02 | 0.00 | 0.01 | 0.10 | 0.02 | 0.01 | 0.02 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.01 |
| LY96 | ENSG00000154589 | 0.01 | 0.00 | 0.01 | 0.01 | 0.08 | 0.00 | 0.07 | 0.00 | 0.14 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.17 | 0.01 | 0.11 | 0.02 | 0.07 | 0.01 | 0.10 | 0.00 | 0.12 | 0.01 | 0.07 | 0.00 | 0.14 | 0.01 | 0.01 | 0.01 | 0.07 | 0.00 | 0.05 | 0.01 | 0.08 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.21 | 0.01 | 0.31 | 0.05 | 0.05 | 0.01 | 0.10 | 0.01 | 0.19 | 0.02 | 0.17 | 0.03 | 0.19 | 0.00 | 0.01 | 0.00 | 0.00 | 0.05 | 0.01 | 0.01 | 0.01 | 0.02 | 0.22 | 0.00 | 0.08 | 0.01 |
| GUCY1A3 | ENSG00000164116 | 0.01 | 0.02 | 0.00 | 0.02 | 0.06 | 0.02 | 0.03 | 0.03 | 0.06 | 0.12 | 0.00 | 0.02 | 0.00 | 0.01 | 0.04 | 0.06 | 0.02 | 0.11 | 0.02 | 0.10 | 0.05 | 0.06 | 0.05 | 0.07 | 0.01 | 0.06 | 0.02 | 0.03 | 0.04 | 0.03 | 0.06 | 0.06 | 0.00 | 0.12 | 0.10 | 0.05 | 0.00 | 0.03 | 0.00 | 0.00 | 0.05 | 0.07 | 0.06 | 0.25 | 0.02 | 0.08 | 0.02 | 0.05 | 0.08 | 0.05 | 0.11 | 0.11 | 0.01 | 0.01 | 0.00 | 0.00 | 0.03 | 0.03 | 0.00 | 0.09 | 0.01 | 0.03 | 0.00 | 0.00 | 0.05 | 0.06 |
| PDIA5 | ENSG00000065485 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.02 | 0.06 | 0.02 | 0.00 | 0.01 | 0.00 | 0.01 | 0.04 | 0.03 | 0.11 | 0.01 | 0.03 | 0.01 | 0.08 | 0.04 | 0.05 | 0.01 | 0.00 | 0.00 | 0.03 | 0.01 | 0.00 | 0.00 | 0.02 | 0.01 | 0.00 | 0.02 | 0.09 | 0.01 | 0.00 | 0.05 | 0.00 | 0.00 | 0.04 | 0.04 | 0.26 | 0.04 | 0.06 | 0.01 | 0.05 | 0.01 | 0.05 | 0.09 | 0.10 | 0.06 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.03 | 0.01 | 0.07 | 0.00 | 0.00 | 0.00 | 0.04 |
| ATP10D | ENSG00000145246 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.03 | 0.04 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.09 | 0.02 | 0.14 | 0.03 | 0.04 | 0.02 | 0.12 | 0.05 | 0.03 | 0.02 | 0.02 | 0.00 | 0.01 | 0.03 | 0.02 | 0.02 | 0.05 | 0.00 | 0.00 | 0.07 | 0.04 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.01 | 0.15 | 0.03 | 0.00 | 0.02 | 0.02 | 0.01 | 0.04 | 0.00 | 0.09 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.02 | 0.01 | 0.01 | 0.05 | 0.00 | 0.03 | 0.01 |
| TRPM1 | ENSG00000134160 | 0.01 | 0.00 | 0.01 | 0.02 | 0.14 | 0.00 | 0.01 | 0.05 | 0.03 | 0.10 | 0.00 | 0.00 | 0.00 | 0.26 | 0.01 | 0.12 | 0.05 | 0.10 | 0.04 | 0.04 | 0.09 | 0.04 | 0.02 | 0.07 | 0.01 | 0.08 | 0.01 | 0.06 | 0.00 | 0.04 | 0.01 | 0.02 | 0.00 | 0.07 | 0.05 | 0.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.12 | 0.08 | 0.31 | 0.04 | 0.05 | 0.04 | 0.08 | 0.07 | 0.48 | 0.13 | 0.10 | 0.02 | 0.03 | 0.01 | 0.00 | 0.00 | 0.04 | 0.00 | 0.03 | 0.00 | 0.10 | 0.02 | 0.00 | 0.03 | 0.15 |
| ESRRA | ENSG00000173153 | 0.01 | 0.00 | 0.00 | 0.01 | 0.07 | 0.00 | 0.03 | 0.01 | 0.12 | 0.01 | 0.00 | 0.00 | 0.08 | 0.00 | 0.06 | 0.03 | 0.08 | 0.02 | 0.19 | 0.03 | 0.11 | 0.05 | 0.02 | 0.02 | 0.01 | 0.01 | 0.02 | 0.03 | 0.00 | 0.02 | 0.01 | 0.03 | 0.13 | 0.07 | 0.07 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.09 | 0.08 | 0.16 | 0.04 | 0.09 | 0.01 | 0.09 | 0.03 | 0.50 | 0.08 | 0.11 | 0.03 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.08 | 0.05 |
| MAP3K6 | ENSG00000142733 | 0.00 | 0.06 | 0.00 | 0.08 | 0.00 | 0.00 | 0.01 | 0.02 | 0.05 | 0.09 | 0.00 | 0.01 | 0.05 | 0.19 | 0.04 | 0.06 | 0.03 | 0.10 | 0.02 | 0.07 | 0.04 | 0.13 | 0.01 | 0.13 | 0.00 | 0.17 | 0.00 | 0.24 | 0.00 | 0.10 | 0.00 | 0.21 | 0.00 | 1.06 | 0.04 | 0.04 | 0.01 | 0.09 | 0.00 | 0.00 | 0.02 | 0.18 | 0.11 | 0.44 | 0.04 | 0.08 | 0.04 | 0.13 | 0.03 | 0.18 | 0.12 | 0.08 | 0.04 | 0.04 | 0.02 | 0.00 | 0.00 | 0.07 | 0.00 | 0.02 | 0.02 | 0.07 | 0.00 | 0.09 | 0.07 | 0.06 |
| YME1L1 | ENSG00000136758 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.02 | 0.05 | 0.04 | 0.00 | 0.01 | 0.02 | 0.02 | 0.04 | 0.01 | 0.05 | 0.01 | 0.03 | 0.02 | 0.06 | 0.01 | 0.04 | 0.04 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.03 | 0.12 | 0.06 | 0.00 | 0.01 | 0.02 | 0.02 | 0.08 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 |
| PDE8A | ENSG00000073417 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.02 | 0.02 | 0.02 | 0.04 | 0.03 | 0.03 | 0.00 | 0.11 | 0.00 | 0.04 | 0.02 | 0.15 | 0.01 | 0.04 | 0.02 | 0.17 | 0.04 | 0.12 | 0.02 | 0.04 | 0.01 | 0.03 | 0.00 | 0.05 | 0.01 | 0.05 | 0.04 | 0.05 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.14 | 0.02 | 0.25 | 0.09 | 0.16 | 0.00 | 0.04 | 0.03 | 0.23 | 0.09 | 0.13 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 | 0.01 | 0.01 | 0.01 | 0.02 | 0.00 | 0.00 | 0.18 | 0.01 |
| OTUD5 | ENSG00000068308 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.04 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.10 | 0.01 | 0.05 | 0.02 | 0.01 | 0.03 | 0.04 | 0.04 | 0.04 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.17 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | 0.05 | 0.01 | 0.49 | 0.07 | 0.04 | 0.03 | 0.12 | 0.01 | 0.19 | 0.03 | 0.12 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.07 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.02 | 0.00 |
| ALDH16A1 | ENSG00000161618 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.01 | 0.10 | 0.04 | 0.00 | 0.02 | 0.00 | 0.06 | 0.02 | 0.07 | 0.05 | 0.10 | 0.04 | 0.02 | 0.07 | 0.05 | 0.07 | 0.03 | 0.01 | 0.02 | 0.02 | 0.03 | 0.03 | 0.05 | 0.05 | 0.04 | 0.00 | 0.07 | 0.26 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.12 | 0.04 | 0.04 | 0.31 | 0.05 | 0.06 | 0.06 | 0.05 | 0.10 | 0.18 | 0.04 | 0.18 | 0.00 | 0.04 | 0.01 | 0.00 | 0.07 | 0.05 | 0.01 | 0.13 | 0.03 | 0.12 | 0.00 | 0.00 | 0.02 | 0.02 |
|
Showing page 275 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.