Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 274 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| BMPR2 | ENSG00000204217 | 0.02 | 0.03 | 0.04 | 0.02 | 0.00 | 0.01 | 0.01 | 0.02 | 0.02 | 0.12 | 0.00 | 0.00 | 0.00 | 0.05 | 0.04 | 0.02 | 0.17 | 0.08 | 0.09 | 0.12 | 0.13 | 0.04 | 0.07 | 0.03 | 0.02 | 0.02 | 0.03 | 0.00 | 0.07 | 0.01 | 0.07 | 0.01 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.04 | 0.25 | 0.09 | 0.09 | 0.22 | 0.05 | 0.02 | 0.15 | 0.05 | 0.06 | 0.12 | 0.06 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.01 | 0.00 | 0.01 | 0.02 | 0.02 | 0.02 | 0.02 |
| INPP5E | ENSG00000148384 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.02 | 0.01 | 0.05 | 0.03 | 0.00 | 0.00 | 0.00 | 0.02 | 0.06 | 0.04 | 0.07 | 0.03 | 0.07 | 0.06 | 0.17 | 0.01 | 0.14 | 0.02 | 0.03 | 0.01 | 0.08 | 0.05 | 0.01 | 0.00 | 0.06 | 0.04 | 0.06 | 0.01 | 0.17 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.07 | 0.06 | 0.17 | 0.22 | 0.06 | 0.02 | 0.06 | 0.04 | 0.04 | 0.14 | 0.07 | 0.16 | 0.03 | 0.03 | 0.01 | 0.00 | 0.05 | 0.00 | 0.02 | 0.01 | 0.04 | 0.02 | 0.00 | 0.00 | 0.03 | 0.03 |
| NR1D1 | ENSG00000126368 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.04 | 0.15 | 0.02 | 0.00 | 0.01 | 0.01 | 0.04 | 0.10 | 0.01 | 0.14 | 0.04 | 0.10 | 0.01 | 0.63 | 0.02 | 0.55 | 0.01 | 0.17 | 0.00 | 0.11 | 0.02 | 0.08 | 0.02 | 0.02 | 0.04 | 0.02 | 0.01 | 0.01 | 0.17 | 0.00 | 0.11 | 0.00 | 0.00 | 0.61 | 0.07 | 0.12 | 0.15 | 0.05 | 0.02 | 0.19 | 0.05 | 0.39 | 0.05 | 0.05 | 0.13 | 0.01 | 0.01 | 0.00 | 0.02 | 0.04 | 0.00 | 0.00 | 0.01 | 0.00 | 0.04 | 0.00 | 0.05 | 0.02 | 0.03 |
| TCF20 | ENSG00000100207 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.01 | 0.03 | 0.02 | 0.08 | 0.00 | 0.03 | 0.00 | 0.04 | 0.04 | 0.04 | 0.06 | 0.03 | 0.02 | 0.01 | 0.04 | 0.00 | 0.02 | 0.03 | 0.00 | 0.03 | 0.01 | 0.06 | 0.05 | 0.04 | 0.05 | 0.03 | 0.04 | 0.05 | 0.02 | 0.00 | 0.03 | 0.06 | 0.00 | 0.00 | 0.03 | 0.04 | 0.02 | 0.32 | 0.04 | 0.05 | 0.03 | 0.08 | 0.11 | 0.23 | 0.05 | 0.07 | 0.00 | 0.03 | 0.00 | 0.00 | 0.06 | 0.07 | 0.00 | 0.04 | 0.01 | 0.07 | 0.00 | 0.00 | 0.28 | 0.01 |
| INSRR | ENSG00000027644 | 0.03 | 0.00 | 0.01 | 0.01 | 0.00 | 0.03 | 0.01 | 0.05 | 0.33 | 0.01 | 0.02 | 0.00 | 0.11 | 0.00 | 0.28 | 0.00 | 0.23 | 0.00 | 0.06 | 0.00 | 0.24 | 0.00 | 0.13 | 0.00 | 0.03 | 0.00 | 0.11 | 0.01 | 0.07 | 0.00 | 0.32 | 0.00 | 0.43 | 0.01 | 0.11 | 0.02 | 0.07 | 0.00 | 0.00 | 0.01 | 0.27 | 0.01 | 0.44 | 0.02 | 0.16 | 0.00 | 0.16 | 0.00 | 0.50 | 0.01 | 0.36 | 0.02 | 0.10 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.05 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.16 | 0.01 |
| PLAA | ENSG00000137055 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.03 | 0.05 | 0.11 | 0.00 | 0.02 | 0.01 | 0.55 | 0.05 | 0.09 | 0.15 | 0.17 | 0.05 | 0.10 | 0.11 | 0.13 | 0.03 | 0.11 | 0.01 | 0.01 | 0.00 | 0.02 | 0.04 | 0.13 | 0.00 | 0.04 | 0.00 | 0.01 | 0.01 | 0.08 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.06 | 0.09 | 0.12 | 0.01 | 0.04 | 0.03 | 0.02 | 0.03 | 0.11 | 0.13 | 0.13 | 0.02 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.00 | 0.13 | 0.01 | 0.42 | 0.00 | 0.00 | 0.04 | 0.13 |
| ADK | ENSG00000156110 | 0.00 | 0.01 | 0.00 | 0.01 | 0.03 | 0.00 | 0.01 | 0.07 | 0.13 | 0.05 | 0.00 | 0.00 | 0.01 | 0.00 | 0.04 | 0.02 | 0.07 | 0.06 | 0.04 | 0.06 | 0.07 | 0.13 | 0.17 | 0.07 | 0.05 | 0.03 | 0.13 | 0.05 | 0.06 | 0.00 | 0.04 | 0.05 | 0.25 | 0.01 | 0.06 | 0.00 | 0.04 | 0.00 | 0.00 | 0.01 | 0.18 | 0.04 | 0.26 | 0.13 | 0.01 | 0.01 | 0.21 | 0.04 | 0.47 | 0.02 | 0.06 | 0.14 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.03 | 0.00 | 0.00 | 0.01 | 0.02 |
| BAZ2A | ENSG00000076108 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.04 | 0.03 | 0.00 | 0.00 | 0.02 | 0.02 | 0.11 | 0.01 | 0.03 | 0.01 | 0.01 | 0.02 | 0.08 | 0.04 | 0.07 | 0.02 | 0.02 | 0.00 | 0.02 | 0.01 | 0.03 | 0.01 | 0.05 | 0.01 | 0.00 | 0.01 | 0.32 | 0.02 | 0.07 | 0.00 | 0.00 | 0.00 | 0.04 | 0.04 | 0.21 | 0.04 | 0.03 | 0.00 | 0.06 | 0.00 | 0.28 | 0.06 | 0.13 | 0.07 | 0.02 | 0.00 | 0.00 | 0.00 | 0.12 | 0.00 | 0.02 | 0.03 | 0.10 | 0.05 | 0.00 | 0.00 | 0.10 | 0.03 |
| ADAM9 | ENSG00000168615 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.07 | 0.07 | 0.37 | 0.06 | 0.00 | 0.00 | 0.04 | 0.00 | 0.18 | 0.03 | 0.79 | 0.03 | 0.26 | 0.02 | 0.28 | 0.05 | 0.07 | 0.04 | 0.20 | 0.03 | 0.14 | 0.04 | 0.06 | 0.00 | 0.09 | 0.06 | 0.03 | 0.01 | 0.09 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.61 | 0.04 | 0.21 | 0.10 | 0.09 | 0.03 | 0.12 | 0.03 | 0.71 | 0.11 | 0.20 | 0.06 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.04 | 0.04 |
| BPNT1 | ENSG00000162813 | 0.01 | 0.02 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.06 | 0.09 | 0.06 | 0.02 | 0.02 | 0.05 | 0.01 | 0.08 | 0.01 | 0.12 | 0.01 | 0.05 | 0.00 | 0.20 | 0.03 | 0.06 | 0.01 | 0.03 | 0.00 | 0.06 | 0.02 | 0.00 | 0.01 | 0.13 | 0.02 | 0.16 | 0.02 | 0.08 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.22 | 0.02 | 0.28 | 0.12 | 0.06 | 0.01 | 0.07 | 0.02 | 0.16 | 0.00 | 0.05 | 0.21 | 0.02 | 0.03 | 0.01 | 0.00 | 0.07 | 0.07 | 0.00 | 0.02 | 0.01 | 0.06 | 0.09 | 0.00 | 0.11 | 0.03 |
| CAPN15 | ENSG00000103326 | 0.01 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.02 | 0.01 | 0.03 | 0.15 | 0.00 | 0.00 | 0.04 | 0.02 | 0.06 | 0.05 | 0.05 | 0.09 | 0.03 | 0.03 | 0.02 | 0.14 | 0.05 | 0.09 | 0.03 | 0.04 | 0.03 | 0.03 | 0.01 | 0.03 | 0.03 | 0.06 | 0.00 | 0.05 | 0.14 | 0.02 | 0.00 | 0.02 | 0.00 | 0.00 | 0.08 | 0.03 | 0.14 | 0.22 | 0.10 | 0.06 | 0.09 | 0.05 | 0.14 | 0.19 | 0.08 | 0.09 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.06 | 0.01 | 0.00 | 0.02 | 0.03 | 0.00 | 0.00 | 0.04 | 0.04 |
| MAST3 | ENSG00000099308 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.00 | 0.03 | 0.05 | 0.01 | 0.03 | 0.02 | 0.09 | 0.02 | 0.05 | 0.02 | 0.11 | 0.01 | 0.05 | 0.02 | 0.01 | 0.00 | 0.01 | 0.04 | 0.01 | 0.02 | 0.09 | 0.03 | 0.06 | 0.03 | 0.13 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.02 | 0.53 | 0.04 | 0.02 | 0.02 | 0.19 | 0.03 | 0.33 | 0.07 | 0.07 | 0.02 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.03 | 0.01 |
| NEK1 | ENSG00000137601 | 0.00 | 0.03 | 0.00 | 0.02 | 0.06 | 0.02 | 0.04 | 0.02 | 0.05 | 0.14 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.09 | 0.02 | 0.17 | 0.02 | 0.09 | 0.08 | 0.08 | 0.07 | 0.12 | 0.04 | 0.07 | 0.02 | 0.05 | 0.00 | 0.05 | 0.06 | 0.11 | 0.00 | 0.17 | 0.14 | 0.08 | 0.00 | 0.03 | 0.00 | 0.00 | 0.06 | 0.09 | 0.10 | 0.31 | 0.05 | 0.10 | 0.02 | 0.06 | 0.12 | 0.10 | 0.11 | 0.18 | 0.01 | 0.00 | 0.02 | 0.00 | 0.03 | 0.09 | 0.00 | 0.12 | 0.00 | 0.07 | 0.00 | 0.00 | 0.05 | 0.05 |
| SLC41A1 | ENSG00000133065 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.02 | 0.06 | 0.06 | 0.01 | 0.00 | 0.10 | 0.00 | 0.12 | 0.01 | 0.09 | 0.01 | 0.05 | 0.00 | 0.17 | 0.07 | 0.06 | 0.02 | 0.04 | 0.00 | 0.12 | 0.02 | 0.00 | 0.00 | 0.19 | 0.01 | 0.18 | 0.02 | 0.03 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.28 | 0.01 | 0.28 | 0.09 | 0.07 | 0.00 | 0.14 | 0.01 | 0.26 | 0.04 | 0.05 | 0.17 | 0.05 | 0.02 | 0.01 | 0.00 | 0.21 | 0.04 | 0.00 | 0.01 | 0.05 | 0.02 | 0.09 | 0.00 | 0.16 | 0.02 |
| CORIN | ENSG00000145244 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.03 | 0.04 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.09 | 0.02 | 0.15 | 0.03 | 0.04 | 0.02 | 0.12 | 0.03 | 0.04 | 0.03 | 0.03 | 0.01 | 0.01 | 0.03 | 0.02 | 0.02 | 0.05 | 0.00 | 0.00 | 0.07 | 0.04 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.01 | 0.16 | 0.03 | 0.01 | 0.02 | 0.02 | 0.01 | 0.04 | 0.00 | 0.11 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.02 | 0.01 | 0.01 | 0.05 | 0.00 | 0.03 | 0.01 |
| GNPTG | ENSG00000090581 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.15 | 0.00 | 0.00 | 0.04 | 0.02 | 0.05 | 0.04 | 0.04 | 0.08 | 0.03 | 0.03 | 0.03 | 0.12 | 0.04 | 0.08 | 0.03 | 0.04 | 0.03 | 0.03 | 0.01 | 0.02 | 0.04 | 0.03 | 0.00 | 0.05 | 0.16 | 0.02 | 0.00 | 0.02 | 0.00 | 0.00 | 0.10 | 0.02 | 0.12 | 0.19 | 0.10 | 0.05 | 0.03 | 0.04 | 0.17 | 0.19 | 0.09 | 0.03 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.04 | 0.01 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.05 | 0.02 |
| CALR | ENSG00000179218 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.05 | 0.05 | 0.01 | 0.00 | 0.09 | 0.00 | 0.00 | 0.05 | 0.09 | 0.05 | 0.07 | 0.02 | 0.11 | 0.05 | 0.03 | 0.03 | 0.00 | 0.01 | 0.01 | 0.02 | 0.01 | 0.02 | 0.04 | 0.10 | 0.00 | 0.01 | 0.17 | 0.03 | 0.00 | 0.00 | 0.00 | 0.01 | 0.08 | 0.04 | 0.77 | 0.11 | 0.14 | 0.04 | 0.23 | 0.03 | 0.25 | 0.14 | 0.17 | 0.03 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.01 | 0.01 | 0.03 | 0.01 | 0.02 | 0.00 | 0.02 | 0.02 |
| BOK | ENSG00000176720 | 0.01 | 0.08 | 0.04 | 0.05 | 0.00 | 0.10 | 0.02 | 0.04 | 0.00 | 0.32 | 0.00 | 0.01 | 0.00 | 0.07 | 0.05 | 0.05 | 0.03 | 0.20 | 0.02 | 0.18 | 0.04 | 0.18 | 0.03 | 0.10 | 0.02 | 0.03 | 0.04 | 0.04 | 0.04 | 0.04 | 0.03 | 0.09 | 0.05 | 0.01 | 0.05 | 0.11 | 0.00 | 0.01 | 0.00 | 0.01 | 0.03 | 0.12 | 0.22 | 0.30 | 0.02 | 0.38 | 0.03 | 0.08 | 0.13 | 0.09 | 0.05 | 0.53 | 0.03 | 0.05 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.15 | 0.00 | 0.04 | 0.04 | 0.05 | 0.01 | 0.14 |
| MAN2A2 | ENSG00000196547 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.02 | 0.04 | 0.03 | 0.03 | 0.00 | 0.06 | 0.00 | 0.06 | 0.01 | 0.20 | 0.00 | 0.06 | 0.02 | 0.22 | 0.01 | 0.24 | 0.01 | 0.05 | 0.01 | 0.06 | 0.00 | 0.06 | 0.00 | 0.06 | 0.05 | 0.05 | 0.01 | 0.07 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.15 | 0.02 | 0.34 | 0.08 | 0.18 | 0.01 | 0.07 | 0.02 | 0.37 | 0.01 | 0.16 | 0.03 | 0.00 | 0.01 | 0.00 | 0.00 | 0.06 | 0.00 | 0.02 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.20 | 0.01 |
| PRKX | ENSG00000183943 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.06 | 0.05 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.07 | 0.10 | 0.06 | 0.03 | 0.02 | 0.06 | 0.09 | 0.07 | 0.04 | 0.02 | 0.02 | 0.07 | 0.08 | 0.00 | 0.01 | 0.01 | 0.03 | 0.02 | 0.01 | 0.09 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.06 | 0.05 | 0.18 | 0.19 | 0.08 | 0.02 | 0.06 | 0.04 | 0.09 | 0.13 | 0.16 | 0.11 | 0.05 | 0.02 | 0.00 | 0.00 | 0.00 | 0.04 | 0.03 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.02 |
|
Showing page 274 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.