Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
PARP3 | ENSG00000041880 | 0.00 | 0.18 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.03 | 0.03 | 0.15 | 0.00 | 0.01 | 0.00 | 0.57 | 0.01 | 0.06 | 0.00 | 0.11 | 0.00 | 0.06 | 0.02 | 0.13 | 0.00 | 0.10 | 0.00 | 0.06 | 0.01 | 0.08 | 0.00 | 0.04 | 0.03 | 0.06 | 0.00 | 0.20 | 0.07 | 0.02 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.17 | 0.06 | 0.20 | 0.01 | 0.06 | 0.07 | 0.06 | 0.00 | 0.29 | 0.05 | 0.15 | 0.05 | 0.01 | 0.00 | 0.01 | 0.00 | 0.06 | 0.00 | 0.06 | 0.02 | 0.04 | 0.00 | 0.03 | 0.02 | 0.05 |
SLC44A5 | ENSG00000137968 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.11 | 0.05 | 0.00 | 0.00 | 0.00 | 0.20 | 0.04 | 0.07 | 0.07 | 0.06 | 0.01 | 0.06 | 0.01 | 0.10 | 0.03 | 0.05 | 0.01 | 0.08 | 0.03 | 0.06 | 0.00 | 0.01 | 0.02 | 0.03 | 0.00 | 0.08 | 0.05 | 0.04 | 0.00 | 0.19 | 0.00 | 0.00 | 0.05 | 0.07 | 0.13 | 0.17 | 0.03 | 0.03 | 0.01 | 0.02 | 0.07 | 0.06 | 0.20 | 0.04 | 0.04 | 0.03 | 0.02 | 0.01 | 0.00 | 0.03 | 0.01 | 0.01 | 0.01 | 0.05 | 0.03 | 0.05 | 0.05 | 0.07 |
SLK | ENSG00000065613 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.10 | 0.03 | 0.09 | 0.00 | 0.02 | 0.01 | 0.20 | 0.02 | 0.04 | 0.02 | 0.08 | 0.00 | 0.04 | 0.05 | 0.07 | 0.05 | 0.08 | 0.00 | 0.10 | 0.01 | 0.07 | 0.01 | 0.03 | 0.02 | 0.07 | 0.11 | 0.17 | 0.06 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.03 | 0.10 | 0.07 | 0.31 | 0.01 | 0.07 | 0.03 | 0.08 | 0.03 | 0.11 | 0.03 | 0.04 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.07 | 0.00 | 0.07 | 0.00 | 0.05 | 0.00 | 0.00 | 0.02 | 0.04 |
LPAR6 | ENSG00000139679 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.39 | 0.02 | 0.34 | 0.00 | 0.00 | 0.00 | 0.19 | 0.01 | 0.08 | 0.01 | 0.18 | 0.02 | 0.15 | 0.05 | 0.16 | 0.10 | 0.05 | 0.10 | 0.04 | 0.10 | 0.04 | 0.01 | 0.03 | 0.00 | 0.35 | 0.00 | 0.09 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.20 | 0.03 | 0.44 | 0.01 | 0.24 | 0.00 | 0.08 | 0.03 | 0.44 | 0.00 | 0.76 | 0.00 | 0.02 | 0.00 | 0.00 | 0.03 | 0.23 | 0.01 | 0.09 | 0.00 | 0.19 | 0.00 | 0.00 | 0.01 | 0.05 |
AZIN1 | ENSG00000155096 | 0.01 | 0.00 | 0.01 | 0.00 | 0.21 | 0.00 | 0.08 | 0.01 | 0.60 | 0.01 | 0.02 | 0.00 | 0.02 | 0.01 | 0.19 | 0.01 | 0.23 | 0.01 | 0.17 | 0.00 | 0.38 | 0.00 | 0.23 | 0.01 | 0.13 | 0.01 | 0.21 | 0.00 | 0.04 | 0.01 | 0.31 | 0.00 | 0.25 | 0.01 | 0.04 | 0.00 | 0.00 | 0.03 | 0.00 | 0.00 | 0.48 | 0.01 | 0.70 | 0.07 | 0.14 | 0.00 | 0.11 | 0.01 | 0.49 | 0.00 | 0.15 | 0.05 | 0.08 | 0.00 | 0.00 | 0.00 | 0.08 | 0.02 | 0.14 | 0.00 | 0.01 | 0.01 | 0.42 | 0.00 | 0.14 | 0.00 |
TNKS | ENSG00000173273 | 0.01 | 0.02 | 0.01 | 0.01 | 0.00 | 0.01 | 0.01 | 0.14 | 0.02 | 0.14 | 0.00 | 0.00 | 0.02 | 0.03 | 0.04 | 0.07 | 0.03 | 0.12 | 0.00 | 0.08 | 0.18 | 0.06 | 0.19 | 0.03 | 0.01 | 0.10 | 0.00 | 0.20 | 0.01 | 0.05 | 0.02 | 0.12 | 0.00 | 0.01 | 0.05 | 0.02 | 0.00 | 0.02 | 0.00 | 0.00 | 0.03 | 0.15 | 0.04 | 0.41 | 0.01 | 0.05 | 0.01 | 0.09 | 0.10 | 0.24 | 0.04 | 0.09 | 0.02 | 0.01 | 0.00 | 0.00 | 0.04 | 0.06 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.01 | 0.02 | 0.03 |
BAD | ENSG00000002330 | 0.01 | 0.00 | 0.00 | 0.01 | 0.07 | 0.00 | 0.03 | 0.01 | 0.12 | 0.01 | 0.00 | 0.00 | 0.08 | 0.00 | 0.06 | 0.03 | 0.08 | 0.02 | 0.19 | 0.03 | 0.11 | 0.05 | 0.02 | 0.03 | 0.01 | 0.01 | 0.02 | 0.03 | 0.00 | 0.02 | 0.02 | 0.03 | 0.13 | 0.07 | 0.07 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.08 | 0.09 | 0.16 | 0.05 | 0.09 | 0.01 | 0.10 | 0.03 | 0.55 | 0.08 | 0.07 | 0.03 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.08 | 0.05 |
CASP9 | ENSG00000132906 | 0.00 | 0.06 | 0.01 | 0.08 | 0.00 | 0.00 | 0.01 | 0.04 | 0.09 | 0.08 | 0.00 | 0.03 | 0.04 | 0.26 | 0.06 | 0.06 | 0.06 | 0.11 | 0.04 | 0.10 | 0.12 | 0.09 | 0.08 | 0.08 | 0.01 | 0.15 | 0.00 | 0.21 | 0.02 | 0.06 | 0.02 | 0.21 | 0.00 | 1.11 | 0.01 | 0.11 | 0.01 | 0.09 | 0.00 | 0.00 | 0.02 | 0.20 | 0.17 | 0.38 | 0.06 | 0.08 | 0.10 | 0.11 | 0.08 | 0.25 | 0.19 | 0.17 | 0.05 | 0.09 | 0.02 | 0.00 | 0.00 | 0.07 | 0.00 | 0.02 | 0.05 | 0.09 | 0.00 | 0.07 | 0.07 | 0.09 |
KDM5C | ENSG00000126012 | 0.01 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.04 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.02 | 0.07 | 0.03 | 0.04 | 0.03 | 0.05 | 0.04 | 0.03 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.01 | 0.24 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.05 | 0.01 | 0.25 | 0.05 | 0.02 | 0.03 | 0.05 | 0.01 | 0.19 | 0.06 | 0.21 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.09 | 0.00 | 0.03 | 0.00 | 0.02 | 0.00 | 0.03 | 0.00 | 0.01 | 0.00 |
KLHL21 | ENSG00000162413 | 0.00 | 0.06 | 0.01 | 0.09 | 0.00 | 0.00 | 0.01 | 0.05 | 0.10 | 0.08 | 0.00 | 0.02 | 0.04 | 0.31 | 0.07 | 0.05 | 0.09 | 0.11 | 0.06 | 0.08 | 0.18 | 0.07 | 0.10 | 0.09 | 0.02 | 0.15 | 0.00 | 0.20 | 0.04 | 0.06 | 0.03 | 0.31 | 0.00 | 1.09 | 0.03 | 0.23 | 0.01 | 0.11 | 0.00 | 0.00 | 0.03 | 0.19 | 0.26 | 0.34 | 0.06 | 0.10 | 0.07 | 0.11 | 0.08 | 0.27 | 0.17 | 0.25 | 0.08 | 0.12 | 0.02 | 0.01 | 0.00 | 0.15 | 0.00 | 0.06 | 0.03 | 0.28 | 0.00 | 0.05 | 0.07 | 0.13 |
CAMKMT | ENSG00000143919 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.07 | 0.08 | 0.00 | 0.00 | 0.00 | 0.01 | 0.05 | 0.07 | 0.01 | 0.16 | 0.02 | 0.04 | 0.02 | 0.05 | 0.03 | 0.02 | 0.03 | 0.00 | 0.03 | 0.02 | 0.03 | 0.01 | 0.02 | 0.06 | 0.02 | 0.00 | 0.05 | 0.00 | 0.07 | 0.00 | 0.01 | 0.00 | 0.00 | 0.05 | 0.02 | 0.27 | 0.05 | 0.07 | 0.00 | 0.08 | 0.02 | 0.15 | 0.02 | 0.05 | 0.05 | 0.12 | 0.01 | 0.00 | 0.01 | 0.10 | 0.02 | 0.01 | 0.00 | 0.00 | 0.01 | 0.03 | 0.00 | 0.01 | 0.01 |
C3AR1 | ENSG00000171860 | 0.01 | 0.01 | 0.00 | 0.01 | 0.02 | 0.00 | 0.01 | 0.07 | 0.09 | 0.03 | 0.01 | 0.00 | 0.00 | 0.05 | 0.05 | 0.07 | 0.14 | 0.01 | 0.11 | 0.02 | 0.09 | 0.02 | 0.04 | 0.07 | 0.04 | 0.02 | 0.08 | 0.03 | 0.02 | 0.07 | 0.01 | 0.05 | 0.14 | 0.05 | 0.05 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.11 | 0.05 | 0.32 | 0.09 | 0.06 | 0.02 | 0.03 | 0.03 | 0.00 | 0.03 | 0.14 | 0.11 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.12 | 0.01 | 0.03 | 0.02 | 0.00 | 0.01 | 0.04 | 0.04 |
PKD2 | ENSG00000118762 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.03 | 0.11 | 0.06 | 0.00 | 0.00 | 0.00 | 0.06 | 0.02 | 0.03 | 0.06 | 0.04 | 0.04 | 0.02 | 0.04 | 0.07 | 0.03 | 0.06 | 0.01 | 0.02 | 0.00 | 0.01 | 0.00 | 0.01 | 0.02 | 0.11 | 0.00 | 0.03 | 0.04 | 0.02 | 0.02 | 0.02 | 0.00 | 0.00 | 0.04 | 0.04 | 0.04 | 0.23 | 0.01 | 0.03 | 0.02 | 0.02 | 0.07 | 0.09 | 0.05 | 0.07 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.05 |
NQO2 | ENSG00000124588 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.05 | 0.19 | 0.10 | 0.00 | 0.05 | 0.02 | 0.01 | 0.09 | 0.02 | 0.09 | 0.09 | 0.05 | 0.06 | 0.10 | 0.23 | 0.05 | 0.11 | 0.02 | 0.03 | 0.02 | 0.04 | 0.00 | 0.07 | 0.19 | 0.02 | 0.06 | 0.08 | 0.08 | 0.05 | 0.01 | 0.01 | 0.00 | 0.00 | 0.10 | 0.08 | 0.44 | 0.10 | 0.10 | 0.06 | 0.09 | 0.03 | 0.21 | 0.05 | 0.06 | 0.14 | 0.04 | 0.03 | 0.00 | 0.00 | 0.10 | 0.01 | 0.02 | 0.04 | 0.03 | 0.03 | 0.22 | 0.00 | 0.22 | 0.01 |
KLK11 | ENSG00000167757 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.00 | 0.13 | 0.04 | 0.00 | 0.00 | 0.00 | 0.06 | 0.02 | 0.08 | 0.07 | 0.10 | 0.03 | 0.02 | 0.07 | 0.03 | 0.09 | 0.03 | 0.02 | 0.02 | 0.02 | 0.04 | 0.04 | 0.04 | 0.05 | 0.03 | 0.00 | 0.07 | 0.23 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.12 | 0.04 | 0.11 | 0.31 | 0.07 | 0.07 | 0.04 | 0.06 | 0.22 | 0.13 | 0.02 | 0.18 | 0.00 | 0.04 | 0.01 | 0.00 | 0.13 | 0.03 | 0.01 | 0.16 | 0.01 | 0.15 | 0.00 | 0.00 | 0.03 | 0.03 |
GSN | ENSG00000148180 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.03 | 0.05 | 0.00 | 0.01 | 0.01 | 0.01 | 0.05 | 0.02 | 0.06 | 0.02 | 0.05 | 0.01 | 0.11 | 0.02 | 0.07 | 0.02 | 0.01 | 0.01 | 0.05 | 0.03 | 0.00 | 0.01 | 0.04 | 0.04 | 0.06 | 0.04 | 0.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.04 | 0.10 | 0.15 | 0.02 | 0.01 | 0.02 | 0.04 | 0.00 | 0.15 | 0.06 | 0.04 | 0.03 | 0.02 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.01 | 0.03 | 0.01 | 0.00 | 0.00 | 0.02 | 0.01 |
DAG1 | ENSG00000173402 | 0.00 | 0.18 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.02 | 0.03 | 0.15 | 0.00 | 0.01 | 0.00 | 0.54 | 0.01 | 0.06 | 0.00 | 0.10 | 0.00 | 0.06 | 0.01 | 0.13 | 0.02 | 0.11 | 0.00 | 0.06 | 0.01 | 0.06 | 0.00 | 0.04 | 0.04 | 0.06 | 0.00 | 0.24 | 0.02 | 0.02 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.17 | 0.09 | 0.19 | 0.00 | 0.06 | 0.05 | 0.05 | 0.04 | 0.30 | 0.04 | 0.16 | 0.02 | 0.03 | 0.00 | 0.01 | 0.00 | 0.16 | 0.00 | 0.05 | 0.02 | 0.04 | 0.00 | 0.03 | 0.01 | 0.04 |
LSS | ENSG00000160285 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.00 | 0.04 | 0.07 | 0.04 | 0.00 | 0.02 | 0.02 | 0.01 | 0.06 | 0.02 | 0.06 | 0.07 | 0.03 | 0.07 | 0.07 | 0.06 | 0.02 | 0.06 | 0.01 | 0.02 | 0.02 | 0.09 | 0.02 | 0.01 | 0.04 | 0.03 | 0.05 | 0.07 | 0.01 | 0.08 | 0.01 | 0.00 | 0.00 | 0.00 | 0.12 | 0.02 | 0.21 | 0.18 | 0.05 | 0.05 | 0.04 | 0.03 | 0.06 | 0.16 | 0.13 | 0.18 | 0.04 | 0.01 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.03 | 0.03 | 0.00 | 0.02 | 0.04 |
MAP3K13 | ENSG00000073803 | 0.05 | 0.00 | 0.03 | 0.01 | 0.00 | 0.01 | 0.03 | 0.04 | 0.17 | 0.01 | 0.00 | 0.00 | 0.00 | 0.07 | 0.15 | 0.05 | 1.77 | 0.00 | 0.62 | 0.00 | 0.67 | 0.02 | 0.23 | 0.01 | 0.05 | 0.01 | 0.06 | 0.02 | 0.03 | 0.02 | 0.12 | 0.02 | 0.12 | 0.01 | 0.10 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.20 | 0.02 | 1.10 | 0.03 | 0.62 | 0.00 | 0.33 | 0.01 | 0.88 | 0.09 | 0.11 | 0.09 | 0.24 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 | 0.03 | 0.01 | 0.15 | 0.03 | 0.00 | 0.00 | 0.04 | 0.04 |
HCK | ENSG00000101336 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.31 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.10 | 0.01 | 0.23 | 0.00 | 0.18 | 0.00 | 0.08 | 0.00 | 0.07 | 0.00 | 0.16 | 0.00 | 0.23 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.05 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.02 | 0.28 | 0.02 | 0.21 | 0.00 | 0.18 | 0.00 | 1.49 | 0.00 | 0.12 | 0.02 | 0.12 | 0.00 | 0.05 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 |
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