Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 261 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| LAMC1 | ENSG00000135862 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.03 | 0.24 | 0.02 | 0.02 | 0.00 | 0.10 | 0.03 | 0.10 | 0.00 | 0.15 | 0.01 | 0.04 | 0.00 | 0.15 | 0.02 | 0.10 | 0.00 | 0.03 | 0.00 | 0.12 | 0.01 | 0.04 | 0.00 | 0.15 | 0.02 | 0.20 | 0.01 | 0.00 | 0.05 | 0.02 | 0.00 | 0.01 | 0.00 | 0.17 | 0.01 | 0.39 | 0.03 | 0.08 | 0.01 | 0.12 | 0.00 | 0.49 | 0.03 | 0.26 | 0.04 | 0.07 | 0.00 | 0.01 | 0.00 | 0.30 | 0.02 | 0.01 | 0.01 | 0.02 | 0.01 | 0.04 | 0.00 | 0.12 | 0.02 |
| AAK1 | ENSG00000115977 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.04 | 0.01 | 0.18 | 0.00 | 0.04 | 0.00 | 0.15 | 0.01 | 0.06 | 0.01 | 0.00 | 0.01 | 0.02 | 0.01 | 0.00 | 0.01 | 0.02 | 0.05 | 0.00 | 0.08 | 0.03 | 0.04 | 0.00 | 0.01 | 0.00 | 0.00 | 0.06 | 0.01 | 0.17 | 0.05 | 0.03 | 0.00 | 0.10 | 0.01 | 0.18 | 0.00 | 0.06 | 0.04 | 0.03 | 0.04 | 0.00 | 0.00 | 0.04 | 0.02 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.01 |
| VRK1 | ENSG00000100749 | 0.00 | 0.02 | 0.01 | 0.01 | 0.00 | 0.04 | 0.01 | 0.04 | 0.05 | 0.06 | 0.00 | 0.00 | 0.00 | 0.07 | 0.04 | 0.05 | 0.15 | 0.02 | 0.06 | 0.04 | 0.07 | 0.05 | 0.03 | 0.06 | 0.00 | 0.04 | 0.01 | 0.02 | 0.01 | 0.02 | 0.00 | 0.11 | 0.00 | 0.31 | 0.14 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.05 | 0.08 | 0.21 | 0.17 | 0.07 | 0.09 | 0.04 | 0.03 | 0.06 | 0.02 | 0.11 | 0.10 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.09 | 0.04 | 0.07 | 0.03 | 0.01 | 0.01 | 0.06 |
| KCNJ12 | ENSG00000184185 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.02 | 0.15 | 0.07 | 0.03 | 0.01 | 0.01 | 0.03 | 0.07 | 0.04 | 0.09 | 0.06 | 0.03 | 0.05 | 0.04 | 0.11 | 0.05 | 0.08 | 0.07 | 0.03 | 0.05 | 0.08 | 0.04 | 0.01 | 0.07 | 0.04 | 0.09 | 0.01 | 0.00 | 0.02 | 0.00 | 0.05 | 0.00 | 0.00 | 0.12 | 0.06 | 0.05 | 0.12 | 0.06 | 0.06 | 0.10 | 0.06 | 0.13 | 0.20 | 0.69 | 0.08 | 0.07 | 0.03 | 0.00 | 0.00 | 0.10 | 0.00 | 0.01 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.05 | 0.03 |
| INSL3 | ENSG00000248099 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.00 | 0.03 | 0.05 | 0.01 | 0.02 | 0.02 | 0.10 | 0.03 | 0.05 | 0.02 | 0.12 | 0.01 | 0.03 | 0.02 | 0.02 | 0.00 | 0.01 | 0.04 | 0.01 | 0.02 | 0.08 | 0.03 | 0.06 | 0.03 | 0.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.02 | 0.58 | 0.03 | 0.02 | 0.01 | 0.22 | 0.02 | 0.25 | 0.07 | 0.08 | 0.02 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.01 | 0.02 | 0.00 | 0.04 | 0.01 |
| SCN2A | ENSG00000136531 | 0.02 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.01 | 0.10 | 0.07 | 0.05 | 0.00 | 0.01 | 0.00 | 0.00 | 0.07 | 0.01 | 0.11 | 0.03 | 0.07 | 0.01 | 0.10 | 0.03 | 0.03 | 0.05 | 0.01 | 0.02 | 0.01 | 0.02 | 0.02 | 0.01 | 0.04 | 0.06 | 0.00 | 0.01 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.03 | 0.29 | 0.05 | 0.07 | 0.01 | 0.05 | 0.01 | 0.03 | 0.00 | 0.06 | 0.08 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.11 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.02 |
| FCAMR | ENSG00000162897 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.02 | 0.07 | 0.06 | 0.01 | 0.00 | 0.07 | 0.01 | 0.12 | 0.01 | 0.10 | 0.01 | 0.05 | 0.00 | 0.19 | 0.06 | 0.12 | 0.01 | 0.04 | 0.00 | 0.12 | 0.02 | 0.00 | 0.00 | 0.19 | 0.01 | 0.18 | 0.02 | 0.01 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.28 | 0.01 | 0.22 | 0.11 | 0.07 | 0.00 | 0.07 | 0.02 | 0.20 | 0.04 | 0.04 | 0.18 | 0.03 | 0.02 | 0.01 | 0.00 | 0.16 | 0.10 | 0.00 | 0.01 | 0.04 | 0.02 | 0.09 | 0.00 | 0.15 | 0.02 |
| PI4KB | ENSG00000143393 | 0.03 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.07 | 0.00 | 0.57 | 0.01 | 0.02 | 0.00 | 0.11 | 0.02 | 0.42 | 0.00 | 0.30 | 0.00 | 0.08 | 0.01 | 0.27 | 0.00 | 0.22 | 0.00 | 0.03 | 0.00 | 0.17 | 0.00 | 0.06 | 0.00 | 0.38 | 0.00 | 0.43 | 0.01 | 0.23 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.36 | 0.01 | 0.71 | 0.02 | 0.22 | 0.00 | 0.34 | 0.00 | 0.84 | 0.00 | 0.47 | 0.02 | 0.12 | 0.01 | 0.00 | 0.00 | 0.24 | 0.00 | 0.02 | 0.00 | 0.06 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 |
| IGF2R | ENSG00000197081 | 0.00 | 0.06 | 0.00 | 0.01 | 0.00 | 0.05 | 0.00 | 0.04 | 0.02 | 0.08 | 0.00 | 0.02 | 0.00 | 0.18 | 0.02 | 0.06 | 0.07 | 0.05 | 0.03 | 0.04 | 0.08 | 0.05 | 0.07 | 0.07 | 0.02 | 0.01 | 0.03 | 0.03 | 0.00 | 0.03 | 0.02 | 0.12 | 0.00 | 0.18 | 0.09 | 0.03 | 0.00 | 0.02 | 0.00 | 0.00 | 0.05 | 0.12 | 0.07 | 0.44 | 0.00 | 0.10 | 0.03 | 0.04 | 0.08 | 0.05 | 0.19 | 0.06 | 0.01 | 0.05 | 0.00 | 0.00 | 0.06 | 0.02 | 0.00 | 0.05 | 0.00 | 0.10 | 0.06 | 0.06 | 0.01 | 0.15 |
| PIP | ENSG00000159763 | 0.01 | 0.01 | 0.05 | 0.00 | 0.05 | 0.02 | 0.02 | 0.03 | 0.05 | 0.03 | 0.00 | 0.01 | 0.04 | 0.03 | 0.08 | 0.02 | 0.08 | 0.06 | 0.02 | 0.15 | 0.04 | 0.20 | 0.03 | 0.10 | 0.02 | 0.01 | 0.01 | 0.03 | 0.02 | 0.04 | 0.04 | 0.05 | 0.00 | 0.11 | 0.06 | 0.09 | 0.00 | 0.02 | 0.00 | 0.00 | 0.09 | 0.04 | 0.53 | 0.04 | 0.03 | 0.09 | 0.04 | 0.05 | 0.05 | 0.14 | 0.12 | 0.11 | 0.02 | 0.04 | 0.00 | 0.05 | 0.02 | 0.09 | 0.11 | 0.01 | 0.04 | 0.02 | 0.00 | 0.03 | 0.21 | 0.02 |
| CHD2 | ENSG00000173575 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.01 | 0.05 | 0.03 | 0.03 | 0.00 | 0.06 | 0.00 | 0.08 | 0.01 | 0.23 | 0.00 | 0.08 | 0.02 | 0.21 | 0.03 | 0.27 | 0.01 | 0.04 | 0.01 | 0.06 | 0.02 | 0.06 | 0.00 | 0.07 | 0.06 | 0.05 | 0.01 | 0.06 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.02 | 0.36 | 0.08 | 0.17 | 0.01 | 0.06 | 0.02 | 0.27 | 0.00 | 0.17 | 0.04 | 0.00 | 0.01 | 0.00 | 0.00 | 0.06 | 0.00 | 0.02 | 0.01 | 0.02 | 0.01 | 0.00 | 0.00 | 0.21 | 0.02 |
| IL32 | ENSG00000008517 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.17 | 0.00 | 0.00 | 0.04 | 0.02 | 0.04 | 0.03 | 0.04 | 0.09 | 0.04 | 0.03 | 0.03 | 0.08 | 0.03 | 0.08 | 0.03 | 0.03 | 0.02 | 0.02 | 0.01 | 0.02 | 0.03 | 0.02 | 0.05 | 0.05 | 0.11 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.02 | 0.09 | 0.19 | 0.10 | 0.02 | 0.05 | 0.05 | 0.08 | 0.05 | 0.09 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.05 | 0.01 |
| PRKG2 | ENSG00000138669 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.02 | 0.08 | 0.04 | 0.00 | 0.00 | 0.02 | 0.08 | 0.04 | 0.03 | 0.09 | 0.05 | 0.04 | 0.03 | 0.03 | 0.06 | 0.03 | 0.05 | 0.01 | 0.01 | 0.03 | 0.01 | 0.01 | 0.00 | 0.02 | 0.10 | 0.05 | 0.03 | 0.06 | 0.02 | 0.02 | 0.02 | 0.00 | 0.00 | 0.05 | 0.04 | 0.09 | 0.20 | 0.03 | 0.03 | 0.02 | 0.02 | 0.02 | 0.09 | 0.06 | 0.05 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.05 | 0.00 | 0.03 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.02 |
| CR2 | ENSG00000117322 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.03 | 0.06 | 0.06 | 0.01 | 0.00 | 0.07 | 0.01 | 0.12 | 0.01 | 0.08 | 0.01 | 0.05 | 0.00 | 0.16 | 0.06 | 0.07 | 0.02 | 0.04 | 0.00 | 0.12 | 0.02 | 0.00 | 0.00 | 0.16 | 0.01 | 0.18 | 0.02 | 0.01 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.25 | 0.01 | 0.20 | 0.12 | 0.06 | 0.00 | 0.07 | 0.02 | 0.13 | 0.04 | 0.03 | 0.17 | 0.02 | 0.03 | 0.01 | 0.00 | 0.16 | 0.10 | 0.00 | 0.02 | 0.03 | 0.02 | 0.09 | 0.00 | 0.14 | 0.02 |
| ATP11B | ENSG00000058063 | 0.05 | 0.00 | 0.04 | 0.00 | 0.00 | 0.01 | 0.05 | 0.03 | 0.22 | 0.00 | 0.00 | 0.00 | 0.01 | 0.10 | 0.16 | 0.04 | 2.09 | 0.00 | 0.73 | 0.00 | 0.75 | 0.02 | 0.26 | 0.01 | 0.04 | 0.00 | 0.06 | 0.03 | 0.03 | 0.01 | 0.11 | 0.02 | 0.12 | 0.01 | 0.10 | 0.03 | 0.00 | 0.10 | 0.00 | 0.00 | 0.22 | 0.01 | 1.12 | 0.02 | 0.64 | 0.00 | 0.36 | 0.01 | 0.86 | 0.08 | 0.11 | 0.09 | 0.20 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 | 0.07 | 0.00 | 0.23 | 0.00 | 0.00 | 0.00 | 0.02 | 0.04 |
| KEAP1 | ENSG00000079999 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.02 | 0.11 | 0.04 | 0.00 | 0.01 | 0.09 | 0.01 | 0.02 | 0.06 | 0.08 | 0.06 | 0.05 | 0.04 | 0.07 | 0.06 | 0.06 | 0.04 | 0.03 | 0.01 | 0.02 | 0.03 | 0.01 | 0.03 | 0.02 | 0.12 | 0.00 | 0.01 | 0.11 | 0.03 | 0.00 | 0.00 | 0.00 | 0.01 | 0.10 | 0.04 | 0.58 | 0.19 | 0.13 | 0.05 | 0.24 | 0.07 | 0.81 | 0.13 | 0.28 | 0.02 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.04 | 0.01 | 0.02 | 0.02 | 0.02 | 0.02 |
| CEACAM1 | ENSG00000079385 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.02 | 0.00 | 0.08 | 0.13 | 0.03 | 0.00 | 0.00 | 0.14 | 0.05 | 0.11 | 0.05 | 0.15 | 0.07 | 0.01 | 0.02 | 0.03 | 0.07 | 0.04 | 0.03 | 0.02 | 0.02 | 0.02 | 0.03 | 0.03 | 0.03 | 0.06 | 0.03 | 0.12 | 0.01 | 0.14 | 0.04 | 0.00 | 0.02 | 0.00 | 0.00 | 0.06 | 0.05 | 0.19 | 0.27 | 0.11 | 0.05 | 0.05 | 0.04 | 0.09 | 0.17 | 0.16 | 0.12 | 0.00 | 0.04 | 0.01 | 0.00 | 0.05 | 0.06 | 0.01 | 0.11 | 0.04 | 0.09 | 0.00 | 0.00 | 0.03 | 0.03 |
| IGFBP5 | ENSG00000115461 | 0.01 | 0.07 | 0.04 | 0.03 | 0.00 | 0.03 | 0.01 | 0.03 | 0.01 | 0.26 | 0.00 | 0.00 | 0.00 | 0.12 | 0.02 | 0.03 | 0.04 | 0.19 | 0.00 | 0.18 | 0.03 | 0.11 | 0.05 | 0.03 | 0.02 | 0.02 | 0.02 | 0.02 | 0.06 | 0.03 | 0.03 | 0.04 | 0.00 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.04 | 0.05 | 0.20 | 0.16 | 0.03 | 0.34 | 0.03 | 0.03 | 0.15 | 0.05 | 0.06 | 0.22 | 0.08 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.02 | 0.01 | 0.01 | 0.02 | 0.02 | 0.02 | 0.03 |
| SLC8A1 | ENSG00000183023 | 0.01 | 0.01 | 0.03 | 0.01 | 0.00 | 0.00 | 0.01 | 0.08 | 0.06 | 0.00 | 0.00 | 0.02 | 0.01 | 0.07 | 0.05 | 0.01 | 0.11 | 0.02 | 0.04 | 0.01 | 0.04 | 0.03 | 0.02 | 0.03 | 0.01 | 0.02 | 0.00 | 0.03 | 0.01 | 0.02 | 0.06 | 0.01 | 0.00 | 0.05 | 0.01 | 0.04 | 0.00 | 0.01 | 0.00 | 0.00 | 0.05 | 0.02 | 0.21 | 0.05 | 0.08 | 0.01 | 0.06 | 0.02 | 0.18 | 0.00 | 0.06 | 0.07 | 0.16 | 0.03 | 0.00 | 0.00 | 0.10 | 0.02 | 0.01 | 0.01 | 0.01 | 0.01 | 0.03 | 0.00 | 0.00 | 0.01 |
| STK17B | ENSG00000081320 | 0.03 | 0.02 | 0.08 | 0.00 | 0.00 | 0.01 | 0.03 | 0.01 | 0.02 | 0.08 | 0.00 | 0.00 | 0.00 | 0.04 | 0.04 | 0.02 | 0.16 | 0.04 | 0.10 | 0.05 | 0.13 | 0.03 | 0.06 | 0.04 | 0.02 | 0.01 | 0.02 | 0.01 | 0.07 | 0.01 | 0.05 | 0.01 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.07 | 0.02 | 0.33 | 0.06 | 0.14 | 0.03 | 0.05 | 0.01 | 0.05 | 0.03 | 0.06 | 0.08 | 0.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.02 | 0.02 | 0.02 |
|
Showing page 261 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.