Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 240 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| SLCO1C1 | ENSG00000139155 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.02 | 0.06 | 0.04 | 0.03 | 0.01 | 0.00 | 0.00 | 0.04 | 0.17 | 0.05 | 0.14 | 0.01 | 0.07 | 0.02 | 0.11 | 0.03 | 0.11 | 0.03 | 0.02 | 0.02 | 0.11 | 0.03 | 0.07 | 0.05 | 0.00 | 0.03 | 0.14 | 0.03 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.04 | 0.32 | 0.07 | 0.01 | 0.01 | 0.04 | 0.01 | 0.15 | 0.03 | 0.16 | 0.10 | 0.59 | 0.00 | 0.01 | 0.01 | 0.00 | 0.04 | 0.06 | 0.01 | 0.02 | 0.04 | 0.00 | 0.00 | 0.06 | 0.01 |
| TNFRSF21 | ENSG00000146072 | 0.00 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.02 | 0.02 | 0.07 | 0.03 | 0.00 | 0.00 | 0.01 | 0.02 | 0.11 | 0.02 | 0.18 | 0.04 | 0.06 | 0.03 | 0.30 | 0.03 | 0.19 | 0.01 | 0.06 | 0.00 | 0.11 | 0.01 | 0.02 | 0.00 | 0.09 | 0.00 | 0.00 | 0.03 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.11 | 0.03 | 0.23 | 0.07 | 0.08 | 0.03 | 0.07 | 0.01 | 0.06 | 0.03 | 0.17 | 0.03 | 0.02 | 0.01 | 0.00 | 0.00 | 0.09 | 0.02 | 0.01 | 0.00 | 0.00 | 0.02 | 0.02 | 0.00 | 0.06 | 0.01 |
| AXL | ENSG00000167601 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.01 | 0.04 | 0.13 | 0.03 | 0.00 | 0.00 | 0.08 | 0.02 | 0.09 | 0.04 | 0.17 | 0.07 | 0.02 | 0.02 | 0.03 | 0.05 | 0.06 | 0.03 | 0.03 | 0.01 | 0.01 | 0.02 | 0.07 | 0.03 | 0.03 | 0.03 | 0.12 | 0.01 | 0.07 | 0.04 | 0.00 | 0.02 | 0.00 | 0.00 | 0.06 | 0.04 | 0.19 | 0.26 | 0.08 | 0.04 | 0.06 | 0.04 | 0.16 | 0.17 | 0.30 | 0.10 | 0.00 | 0.04 | 0.01 | 0.00 | 0.05 | 0.00 | 0.02 | 0.07 | 0.01 | 0.08 | 0.00 | 0.00 | 0.02 | 0.02 |
| KCNN1 | ENSG00000105642 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.00 | 0.03 | 0.05 | 0.01 | 0.02 | 0.02 | 0.11 | 0.03 | 0.04 | 0.02 | 0.11 | 0.01 | 0.03 | 0.02 | 0.01 | 0.00 | 0.01 | 0.04 | 0.01 | 0.02 | 0.09 | 0.02 | 0.06 | 0.03 | 0.09 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.02 | 0.55 | 0.04 | 0.03 | 0.02 | 0.21 | 0.03 | 0.30 | 0.07 | 0.07 | 0.02 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.03 | 0.01 |
| RSF1 | ENSG00000048649 | 0.00 | 0.01 | 0.00 | 0.01 | 0.09 | 0.00 | 0.06 | 0.00 | 0.24 | 0.02 | 0.00 | 0.00 | 0.08 | 0.00 | 0.18 | 0.01 | 0.16 | 0.02 | 0.26 | 0.03 | 0.24 | 0.06 | 0.20 | 0.02 | 0.02 | 0.01 | 0.03 | 0.02 | 0.00 | 0.01 | 0.07 | 0.03 | 0.00 | 0.06 | 0.07 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.64 | 0.03 | 0.79 | 0.02 | 0.17 | 0.01 | 0.16 | 0.02 | 0.17 | 0.17 | 0.22 | 0.05 | 0.02 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.01 | 0.00 | 0.00 | 0.35 | 0.01 |
| ALDH7A1 | ENSG00000164904 | 0.25 | 0.01 | 0.03 | 0.01 | 0.00 | 0.00 | 0.02 | 0.06 | 0.01 | 0.06 | 0.00 | 0.00 | 0.00 | 0.08 | 0.02 | 0.07 | 0.00 | 0.07 | 0.00 | 0.05 | 0.02 | 0.07 | 0.02 | 0.11 | 0.00 | 0.08 | 0.01 | 0.04 | 0.00 | 0.03 | 0.06 | 0.04 | 0.05 | 0.01 | 0.27 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.03 | 0.05 | 0.10 | 0.23 | 0.01 | 0.02 | 0.01 | 0.03 | 0.19 | 0.05 | 0.04 | 0.04 | 0.01 | 0.00 | 0.00 | 0.09 | 0.04 | 0.02 | 0.00 | 0.04 | 0.01 | 0.02 | 0.00 | 0.03 | 0.03 | 0.08 |
| CHD3 | ENSG00000170004 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.25 | 0.02 | 0.03 | 0.00 | 0.01 | 0.00 | 0.03 | 0.01 | 0.05 | 0.01 | 0.02 | 0.01 | 0.04 | 0.03 | 0.04 | 0.01 | 0.02 | 0.00 | 0.02 | 0.00 | 0.03 | 0.01 | 0.02 | 0.01 | 0.16 | 0.00 | 0.12 | 0.02 | 0.05 | 0.00 | 0.03 | 0.00 | 0.00 | 0.01 | 0.06 | 0.08 | 0.05 | 0.00 | 0.04 | 0.03 | 0.04 | 0.06 | 0.15 | 0.15 | 0.35 | 0.00 | 0.02 | 0.02 | 0.01 | 0.00 | 0.10 | 0.01 | 0.00 | 0.00 | 0.06 | 0.00 | 0.00 | 0.01 | 0.05 |
| KMT2D | ENSG00000167548 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.04 | 0.00 | 0.00 | 0.00 | 0.04 | 0.06 | 0.01 | 0.03 | 0.02 | 0.01 | 0.05 | 0.06 | 0.07 | 0.04 | 0.04 | 0.02 | 0.00 | 0.02 | 0.01 | 0.00 | 0.05 | 0.02 | 0.01 | 0.09 | 0.01 | 0.16 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.05 | 0.05 | 0.09 | 0.07 | 0.02 | 0.01 | 0.03 | 0.01 | 0.09 | 0.11 | 0.07 | 0.09 | 0.02 | 0.00 | 0.00 | 0.01 | 0.10 | 0.06 | 0.01 | 0.04 | 0.02 | 0.05 | 0.00 | 0.00 | 0.05 | 0.04 |
| ALDH1L1 | ENSG00000144908 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.02 | 0.05 | 0.02 | 0.00 | 0.01 | 0.00 | 0.01 | 0.04 | 0.01 | 0.13 | 0.02 | 0.05 | 0.00 | 0.10 | 0.04 | 0.06 | 0.02 | 0.00 | 0.00 | 0.04 | 0.01 | 0.00 | 0.00 | 0.03 | 0.01 | 0.00 | 0.05 | 0.03 | 0.02 | 0.00 | 0.05 | 0.00 | 0.00 | 0.03 | 0.03 | 0.23 | 0.04 | 0.08 | 0.00 | 0.05 | 0.01 | 0.09 | 0.09 | 0.06 | 0.06 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.01 | 0.02 | 0.01 | 0.06 | 0.00 | 0.00 | 0.00 | 0.05 |
| CD5 | ENSG00000110448 | 0.01 | 0.00 | 0.00 | 0.01 | 0.09 | 0.00 | 0.01 | 0.01 | 0.11 | 0.01 | 0.00 | 0.00 | 0.12 | 0.00 | 0.06 | 0.01 | 0.06 | 0.02 | 0.13 | 0.02 | 0.14 | 0.02 | 0.05 | 0.03 | 0.01 | 0.01 | 0.05 | 0.02 | 0.00 | 0.02 | 0.03 | 0.02 | 0.11 | 0.09 | 0.09 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.14 | 0.06 | 0.12 | 0.05 | 0.05 | 0.01 | 0.04 | 0.02 | 0.17 | 0.14 | 0.06 | 0.02 | 0.00 | 0.05 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.06 | 0.04 |
| ADCY5 | ENSG00000173175 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.02 | 0.05 | 0.02 | 0.00 | 0.01 | 0.00 | 0.01 | 0.04 | 0.02 | 0.11 | 0.01 | 0.03 | 0.00 | 0.08 | 0.04 | 0.05 | 0.01 | 0.00 | 0.00 | 0.03 | 0.01 | 0.00 | 0.00 | 0.03 | 0.01 | 0.00 | 0.05 | 0.03 | 0.01 | 0.00 | 0.05 | 0.00 | 0.00 | 0.03 | 0.04 | 0.23 | 0.04 | 0.06 | 0.01 | 0.06 | 0.01 | 0.05 | 0.09 | 0.10 | 0.06 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.03 | 0.01 | 0.07 | 0.00 | 0.00 | 0.00 | 0.04 |
| JMJD1C | ENSG00000171988 | 0.00 | 0.01 | 0.00 | 0.01 | 0.03 | 0.00 | 0.02 | 0.06 | 0.03 | 0.05 | 0.00 | 0.01 | 0.01 | 0.02 | 0.04 | 0.03 | 0.08 | 0.06 | 0.06 | 0.03 | 0.08 | 0.10 | 0.10 | 0.05 | 0.02 | 0.05 | 0.00 | 0.05 | 0.01 | 0.00 | 0.02 | 0.03 | 0.25 | 0.01 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.10 | 0.04 | 0.19 | 0.12 | 0.03 | 0.02 | 0.08 | 0.04 | 0.17 | 0.10 | 0.03 | 0.09 | 0.00 | 0.01 | 0.00 | 0.00 | 0.08 | 0.00 | 0.01 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.00 | 0.04 |
| OLFM4 | ENSG00000102837 | 0.00 | 0.02 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.33 | 0.03 | 0.22 | 0.00 | 0.00 | 0.00 | 0.14 | 0.04 | 0.06 | 0.03 | 0.11 | 0.02 | 0.10 | 0.11 | 0.06 | 0.14 | 0.03 | 0.10 | 0.02 | 0.11 | 0.04 | 0.01 | 0.02 | 0.01 | 0.25 | 0.00 | 0.03 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | 0.02 | 0.02 | 0.11 | 0.06 | 0.21 | 0.02 | 0.20 | 0.00 | 0.03 | 0.03 | 0.11 | 0.04 | 0.34 | 0.03 | 0.02 | 0.00 | 0.00 | 0.03 | 0.06 | 0.00 | 0.09 | 0.00 | 0.16 | 0.00 | 0.00 | 0.01 | 0.04 |
| UGCG | ENSG00000148154 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.03 | 0.01 | 0.04 | 0.04 | 0.00 | 0.01 | 0.02 | 0.04 | 0.05 | 0.02 | 0.04 | 0.01 | 0.05 | 0.00 | 0.10 | 0.02 | 0.05 | 0.02 | 0.01 | 0.01 | 0.04 | 0.02 | 0.00 | 0.01 | 0.03 | 0.04 | 0.06 | 0.04 | 0.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.04 | 0.12 | 0.12 | 0.01 | 0.01 | 0.03 | 0.03 | 0.00 | 0.15 | 0.08 | 0.01 | 0.03 | 0.01 | 0.01 | 0.00 | 0.05 | 0.00 | 0.00 | 0.01 | 0.02 | 0.01 | 0.00 | 0.00 | 0.04 | 0.01 |
| NR2F2 | ENSG00000185551 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.03 | 0.04 | 0.03 | 0.03 | 0.00 | 0.06 | 0.00 | 0.07 | 0.02 | 0.23 | 0.02 | 0.09 | 0.01 | 0.24 | 0.02 | 0.25 | 0.01 | 0.04 | 0.02 | 0.06 | 0.02 | 0.05 | 0.00 | 0.07 | 0.06 | 0.05 | 0.01 | 0.05 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.18 | 0.03 | 0.38 | 0.07 | 0.17 | 0.02 | 0.05 | 0.02 | 0.14 | 0.04 | 0.23 | 0.04 | 0.00 | 0.01 | 0.00 | 0.00 | 0.06 | 0.00 | 0.02 | 0.01 | 0.02 | 0.02 | 0.00 | 0.00 | 0.19 | 0.02 |
| C8B | ENSG00000021852 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.07 | 0.08 | 0.04 | 0.00 | 0.00 | 0.06 | 0.03 | 0.06 | 0.06 | 0.05 | 0.04 | 0.05 | 0.03 | 0.04 | 0.04 | 0.02 | 0.04 | 0.00 | 0.06 | 0.00 | 0.04 | 0.00 | 0.01 | 0.04 | 0.05 | 0.00 | 0.25 | 0.04 | 0.03 | 0.00 | 0.17 | 0.00 | 0.00 | 0.09 | 0.05 | 0.29 | 0.12 | 0.08 | 0.02 | 0.04 | 0.02 | 0.00 | 0.06 | 0.30 | 0.02 | 0.04 | 0.03 | 0.02 | 0.00 | 0.00 | 0.03 | 0.00 | 0.01 | 0.02 | 0.01 | 0.00 | 0.07 | 0.03 | 0.03 |
| SLC39A3 | ENSG00000141873 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.05 | 0.04 | 0.13 | 0.02 | 0.00 | 0.03 | 0.10 | 0.01 | 0.09 | 0.02 | 0.12 | 0.01 | 0.13 | 0.05 | 0.15 | 0.01 | 0.09 | 0.01 | 0.05 | 0.01 | 0.10 | 0.00 | 0.07 | 0.02 | 0.13 | 0.00 | 0.03 | 0.07 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.04 | 0.14 | 0.03 | 0.90 | 0.09 | 0.18 | 0.00 | 0.27 | 0.07 | 0.75 | 0.19 | 0.14 | 0.00 | 0.00 | 0.00 | 0.01 | 0.02 | 0.03 | 0.02 | 0.02 | 0.06 | 0.01 | 0.01 | 0.02 | 0.03 | 0.05 |
| EIF2AK3 | ENSG00000172071 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.03 | 0.08 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.03 | 0.02 | 0.08 | 0.02 | 0.06 | 0.01 | 0.09 | 0.01 | 0.01 | 0.01 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.01 | 0.02 | 0.02 | 0.00 | 0.02 | 0.08 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.04 | 0.02 | 0.10 | 0.05 | 0.04 | 0.01 | 0.04 | 0.02 | 0.08 | 0.02 | 0.17 | 0.04 | 0.01 | 0.04 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.01 |
| KIRREL2 | ENSG00000126259 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.02 | 0.01 | 0.01 | 0.19 | 0.03 | 0.00 | 0.00 | 0.07 | 0.03 | 0.25 | 0.01 | 0.43 | 0.02 | 0.06 | 0.02 | 0.21 | 0.02 | 0.08 | 0.03 | 0.05 | 0.00 | 0.04 | 0.00 | 0.09 | 0.00 | 0.04 | 0.01 | 0.12 | 0.03 | 0.00 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.12 | 0.02 | 0.66 | 0.06 | 0.20 | 0.02 | 0.17 | 0.02 | 1.25 | 0.01 | 0.27 | 0.06 | 0.01 | 0.02 | 0.00 | 0.00 | 0.08 | 0.00 | 0.02 | 0.01 | 0.04 | 0.03 | 0.00 | 0.00 | 0.03 | 0.01 |
| PLCB4 | ENSG00000101333 | 0.00 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.02 | 0.02 | 0.04 | 0.02 | 0.00 | 0.00 | 0.00 | 0.03 | 0.05 | 0.04 | 0.14 | 0.02 | 0.07 | 0.02 | 0.09 | 0.02 | 0.05 | 0.01 | 0.06 | 0.04 | 0.04 | 0.06 | 0.00 | 0.02 | 0.02 | 0.01 | 0.00 | 0.03 | 0.05 | 0.06 | 0.00 | 0.01 | 0.01 | 0.00 | 0.05 | 0.05 | 0.23 | 0.06 | 0.06 | 0.02 | 0.06 | 0.01 | 0.03 | 0.12 | 0.09 | 0.05 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.02 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.02 |
|
Showing page 240 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.