Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 234 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| HHIP | ENSG00000164161 | 0.01 | 0.02 | 0.00 | 0.01 | 0.06 | 0.00 | 0.02 | 0.02 | 0.12 | 0.08 | 0.00 | 0.00 | 0.00 | 0.01 | 0.03 | 0.03 | 0.02 | 0.10 | 0.03 | 0.04 | 0.11 | 0.04 | 0.07 | 0.05 | 0.01 | 0.02 | 0.02 | 0.02 | 0.00 | 0.02 | 0.06 | 0.05 | 0.00 | 0.03 | 0.10 | 0.05 | 0.00 | 0.02 | 0.00 | 0.00 | 0.06 | 0.04 | 0.10 | 0.16 | 0.03 | 0.05 | 0.03 | 0.03 | 0.04 | 0.04 | 0.14 | 0.08 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.03 | 0.01 | 0.07 | 0.00 | 0.02 | 0.00 | 0.00 | 0.03 | 0.03 |
| COCH | ENSG00000100473 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.04 | 0.06 | 0.00 | 0.00 | 0.00 | 0.02 | 0.40 | 0.01 | 0.09 | 0.06 | 0.05 | 0.04 | 0.15 | 0.04 | 0.06 | 0.03 | 0.03 | 0.02 | 0.00 | 0.05 | 0.00 | 0.01 | 0.06 | 0.02 | 0.05 | 0.02 | 0.12 | 0.04 | 0.00 | 0.01 | 0.00 | 0.00 | 0.15 | 0.02 | 0.21 | 0.11 | 0.08 | 0.01 | 0.06 | 0.02 | 0.04 | 0.07 | 0.20 | 0.04 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.02 | 0.01 | 0.09 | 0.00 | 0.00 | 0.01 | 0.02 |
| LGALS8 | ENSG00000116977 | 0.01 | 0.02 | 0.01 | 0.01 | 0.00 | 0.00 | 0.02 | 0.08 | 0.11 | 0.03 | 0.02 | 0.02 | 0.05 | 0.05 | 0.09 | 0.01 | 0.13 | 0.02 | 0.08 | 0.00 | 0.20 | 0.03 | 0.12 | 0.01 | 0.03 | 0.02 | 0.08 | 0.02 | 0.01 | 0.01 | 0.16 | 0.01 | 0.23 | 0.02 | 0.04 | 0.03 | 0.00 | 0.04 | 0.00 | 0.00 | 0.26 | 0.02 | 0.50 | 0.09 | 0.09 | 0.02 | 0.12 | 0.02 | 0.30 | 0.01 | 0.07 | 0.24 | 0.04 | 0.02 | 0.03 | 0.00 | 0.06 | 0.12 | 0.00 | 0.03 | 0.02 | 0.05 | 0.08 | 0.03 | 0.17 | 0.02 |
| FXR2 | ENSG00000129245 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.26 | 0.02 | 0.04 | 0.00 | 0.01 | 0.00 | 0.03 | 0.01 | 0.05 | 0.01 | 0.03 | 0.01 | 0.04 | 0.03 | 0.04 | 0.02 | 0.04 | 0.00 | 0.03 | 0.00 | 0.05 | 0.01 | 0.04 | 0.00 | 0.16 | 0.02 | 0.08 | 0.04 | 0.05 | 0.00 | 0.06 | 0.00 | 0.00 | 0.01 | 0.08 | 0.10 | 0.04 | 0.00 | 0.04 | 0.04 | 0.03 | 0.09 | 0.16 | 0.05 | 0.60 | 0.00 | 0.02 | 0.02 | 0.02 | 0.00 | 0.13 | 0.00 | 0.01 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.05 |
| KMT2E | ENSG00000005483 | 0.01 | 0.00 | 0.02 | 0.01 | 0.01 | 0.00 | 0.03 | 0.02 | 0.03 | 0.02 | 0.00 | 0.00 | 0.03 | 0.00 | 0.08 | 0.02 | 0.18 | 0.03 | 0.17 | 0.02 | 0.41 | 0.07 | 0.19 | 0.04 | 0.02 | 0.01 | 0.03 | 0.00 | 0.02 | 0.01 | 0.05 | 0.02 | 0.00 | 0.02 | 0.02 | 0.06 | 0.00 | 0.02 | 0.00 | 0.00 | 0.05 | 0.05 | 0.28 | 0.07 | 0.05 | 0.03 | 0.05 | 0.05 | 0.36 | 0.05 | 0.16 | 0.03 | 0.08 | 0.01 | 0.00 | 0.00 | 0.13 | 0.03 | 0.09 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.06 | 0.04 |
| MMP2 | ENSG00000087245 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.05 | 0.01 | 0.04 | 0.00 | 0.00 | 0.00 | 0.04 | 0.04 | 0.03 | 0.04 | 0.02 | 0.03 | 0.04 | 0.09 | 0.01 | 0.02 | 0.03 | 0.04 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.02 | 0.00 | 0.01 | 0.06 | 0.05 | 0.00 | 0.03 | 0.00 | 0.00 | 0.08 | 0.04 | 0.05 | 0.16 | 0.01 | 0.08 | 0.03 | 0.06 | 0.05 | 0.12 | 0.03 | 0.09 | 0.12 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.02 | 0.03 | 0.00 | 0.03 | 0.00 | 0.05 |
| SLC7A9 | ENSG00000021488 | 0.00 | 0.00 | 0.02 | 0.01 | 0.00 | 0.02 | 0.01 | 0.00 | 0.21 | 0.03 | 0.00 | 0.00 | 0.11 | 0.01 | 0.24 | 0.01 | 0.36 | 0.02 | 0.05 | 0.02 | 0.21 | 0.03 | 0.12 | 0.06 | 0.07 | 0.00 | 0.04 | 0.00 | 0.12 | 0.00 | 0.04 | 0.03 | 0.13 | 0.03 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.13 | 0.01 | 0.69 | 0.04 | 0.14 | 0.01 | 0.23 | 0.02 | 1.57 | 0.00 | 0.25 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.13 | 0.00 | 0.01 | 0.00 | 0.03 | 0.03 | 0.00 | 0.00 | 0.05 | 0.01 |
| GART | ENSG00000159131 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.07 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.04 | 0.02 | 0.06 | 0.02 | 0.06 | 0.00 | 0.07 | 0.00 | 0.03 | 0.01 | 0.01 | 0.02 | 0.01 | 0.00 | 0.01 | 0.01 | 0.05 | 0.03 | 0.13 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.06 | 0.01 | 0.11 | 0.04 | 0.02 | 0.01 | 0.03 | 0.00 | 0.07 | 0.03 | 0.04 | 0.04 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.03 | 0.00 | 0.01 | 0.01 |
| KCNQ5 | ENSG00000185760 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.16 | 0.05 | 0.06 | 0.00 | 0.00 | 0.05 | 0.07 | 0.04 | 0.05 | 0.12 | 0.03 | 0.03 | 0.04 | 0.05 | 0.09 | 0.07 | 0.05 | 0.00 | 0.02 | 0.01 | 0.02 | 0.03 | 0.02 | 0.06 | 0.04 | 0.01 | 0.24 | 0.05 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.08 | 0.07 | 0.12 | 0.10 | 0.02 | 0.01 | 0.04 | 0.01 | 0.06 | 0.11 | 0.02 | 0.14 | 0.03 | 0.00 | 0.00 | 0.01 | 0.01 | 0.09 | 0.00 | 0.01 | 0.00 | 0.06 | 0.06 | 0.06 | 0.04 | 0.05 |
| CATSPER1 | ENSG00000175294 | 0.01 | 0.00 | 0.00 | 0.01 | 0.09 | 0.00 | 0.09 | 0.00 | 0.17 | 0.01 | 0.00 | 0.00 | 0.08 | 0.00 | 0.09 | 0.01 | 0.10 | 0.01 | 0.32 | 0.01 | 0.18 | 0.01 | 0.07 | 0.03 | 0.01 | 0.02 | 0.02 | 0.04 | 0.00 | 0.02 | 0.03 | 0.03 | 0.00 | 0.09 | 0.03 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.15 | 0.05 | 0.22 | 0.03 | 0.13 | 0.00 | 0.05 | 0.02 | 0.26 | 0.06 | 0.12 | 0.03 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.00 | 0.01 | 0.03 | 0.00 | 0.00 | 0.07 | 0.05 |
| ITGA9 | ENSG00000144668 | 0.00 | 0.18 | 0.00 | 0.01 | 0.12 | 0.00 | 0.00 | 0.01 | 0.13 | 0.04 | 0.00 | 0.02 | 0.02 | 0.27 | 0.01 | 0.04 | 0.02 | 0.05 | 0.00 | 0.04 | 0.03 | 0.06 | 0.04 | 0.08 | 0.00 | 0.02 | 0.03 | 0.02 | 0.01 | 0.02 | 0.06 | 0.02 | 0.00 | 0.20 | 0.06 | 0.04 | 0.00 | 0.03 | 0.00 | 0.00 | 0.04 | 0.08 | 0.13 | 0.17 | 0.02 | 0.03 | 0.03 | 0.04 | 0.12 | 0.13 | 0.09 | 0.06 | 0.03 | 0.04 | 0.00 | 0.01 | 0.04 | 0.09 | 0.01 | 0.03 | 0.01 | 0.03 | 0.00 | 0.00 | 0.04 | 0.04 |
| AHSG | ENSG00000145192 | 0.05 | 0.00 | 0.03 | 0.01 | 0.00 | 0.01 | 0.03 | 0.04 | 0.19 | 0.01 | 0.00 | 0.00 | 0.00 | 0.07 | 0.14 | 0.05 | 1.57 | 0.00 | 0.61 | 0.00 | 0.70 | 0.02 | 0.21 | 0.01 | 0.04 | 0.01 | 0.06 | 0.02 | 0.03 | 0.00 | 0.13 | 0.02 | 0.12 | 0.03 | 0.10 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.18 | 0.02 | 1.06 | 0.04 | 0.62 | 0.00 | 0.33 | 0.01 | 0.78 | 0.09 | 0.12 | 0.09 | 0.24 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 | 0.02 | 0.02 | 0.12 | 0.05 | 0.00 | 0.00 | 0.03 | 0.04 |
| THRA | ENSG00000126351 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.04 | 0.15 | 0.02 | 0.00 | 0.01 | 0.01 | 0.04 | 0.11 | 0.01 | 0.14 | 0.04 | 0.10 | 0.01 | 0.65 | 0.02 | 0.63 | 0.01 | 0.19 | 0.00 | 0.11 | 0.02 | 0.08 | 0.02 | 0.03 | 0.04 | 0.02 | 0.01 | 0.01 | 0.17 | 0.01 | 0.11 | 0.00 | 0.00 | 0.66 | 0.07 | 0.12 | 0.15 | 0.08 | 0.02 | 0.19 | 0.05 | 0.41 | 0.10 | 0.05 | 0.13 | 0.01 | 0.01 | 0.00 | 0.02 | 0.04 | 0.00 | 0.00 | 0.01 | 0.01 | 0.04 | 0.00 | 0.05 | 0.02 | 0.03 |
| AGRN | ENSG00000188157 | 0.00 | 0.05 | 0.01 | 0.10 | 0.00 | 0.00 | 0.02 | 0.03 | 0.10 | 0.08 | 0.00 | 0.02 | 0.04 | 0.27 | 0.09 | 0.06 | 0.08 | 0.11 | 0.06 | 0.09 | 0.13 | 0.08 | 0.09 | 0.09 | 0.02 | 0.11 | 0.00 | 0.17 | 0.05 | 0.05 | 0.02 | 0.31 | 0.00 | 1.01 | 0.05 | 0.17 | 0.01 | 0.12 | 0.00 | 0.00 | 0.04 | 0.19 | 0.23 | 0.38 | 0.06 | 0.11 | 0.05 | 0.12 | 0.08 | 0.27 | 0.18 | 0.28 | 0.10 | 0.12 | 0.02 | 0.00 | 0.00 | 0.19 | 0.00 | 0.03 | 0.03 | 0.15 | 0.00 | 0.14 | 0.07 | 0.13 |
| RECK | ENSG00000122707 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.13 | 0.03 | 0.00 | 0.01 | 0.01 | 0.08 | 0.05 | 0.04 | 0.38 | 0.04 | 0.25 | 0.04 | 0.21 | 0.04 | 0.18 | 0.03 | 0.02 | 0.00 | 0.00 | 0.00 | 0.13 | 0.00 | 0.04 | 0.02 | 0.19 | 0.05 | 0.12 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.07 | 0.02 | 0.12 | 0.06 | 0.02 | 0.01 | 0.04 | 0.02 | 0.04 | 0.11 | 0.11 | 0.05 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.04 | 0.05 | 0.00 | 0.03 | 0.10 | 0.05 |
| ITIH3 | ENSG00000162267 | 0.00 | 0.17 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.03 | 0.03 | 0.16 | 0.00 | 0.03 | 0.00 | 0.61 | 0.01 | 0.06 | 0.00 | 0.11 | 0.00 | 0.06 | 0.05 | 0.13 | 0.01 | 0.11 | 0.00 | 0.06 | 0.02 | 0.07 | 0.00 | 0.04 | 0.03 | 0.07 | 0.00 | 0.20 | 0.08 | 0.01 | 0.00 | 0.04 | 0.00 | 0.00 | 0.01 | 0.17 | 0.08 | 0.22 | 0.00 | 0.07 | 0.03 | 0.08 | 0.00 | 0.30 | 0.03 | 0.15 | 0.05 | 0.01 | 0.00 | 0.01 | 0.00 | 0.06 | 0.01 | 0.06 | 0.01 | 0.04 | 0.00 | 0.03 | 0.02 | 0.04 |
| SLC5A6 | ENSG00000138074 | 0.00 | 0.00 | 0.04 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 | 0.09 | 0.01 | 0.00 | 0.00 | 0.03 | 0.07 | 0.06 | 0.01 | 0.10 | 0.01 | 0.03 | 0.01 | 0.05 | 0.05 | 0.04 | 0.03 | 0.01 | 0.00 | 0.02 | 0.02 | 0.01 | 0.04 | 0.11 | 0.00 | 0.00 | 0.05 | 0.06 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.03 | 0.21 | 0.07 | 0.08 | 0.00 | 0.11 | 0.02 | 0.25 | 0.00 | 0.04 | 0.08 | 0.17 | 0.01 | 0.00 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.01 | 0.02 | 0.05 | 0.00 | 0.03 | 0.03 |
| PRKG1 | ENSG00000185532 | 0.00 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.01 | 0.05 | 0.06 | 0.06 | 0.00 | 0.00 | 0.01 | 0.05 | 0.03 | 0.03 | 0.07 | 0.02 | 0.06 | 0.03 | 0.09 | 0.13 | 0.05 | 0.06 | 0.01 | 0.13 | 0.03 | 0.14 | 0.01 | 0.01 | 0.02 | 0.02 | 0.09 | 0.04 | 0.04 | 0.05 | 0.00 | 0.03 | 0.00 | 0.01 | 0.05 | 0.04 | 0.08 | 0.15 | 0.04 | 0.02 | 0.04 | 0.04 | 0.19 | 0.03 | 0.07 | 0.11 | 0.00 | 0.05 | 0.00 | 0.00 | 0.00 | 0.03 | 0.03 | 0.00 | 0.01 | 0.05 | 0.02 | 0.00 | 0.01 | 0.06 |
| TP53BP1 | ENSG00000067369 | 0.00 | 0.01 | 0.00 | 0.02 | 0.14 | 0.00 | 0.01 | 0.06 | 0.02 | 0.06 | 0.00 | 0.00 | 0.02 | 0.33 | 0.01 | 0.09 | 0.02 | 0.08 | 0.02 | 0.04 | 0.04 | 0.05 | 0.01 | 0.07 | 0.01 | 0.08 | 0.00 | 0.06 | 0.00 | 0.04 | 0.00 | 0.03 | 0.00 | 0.07 | 0.02 | 0.09 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.11 | 0.06 | 0.33 | 0.01 | 0.09 | 0.02 | 0.08 | 0.05 | 0.30 | 0.07 | 0.07 | 0.01 | 0.03 | 0.00 | 0.00 | 0.02 | 0.15 | 0.00 | 0.03 | 0.01 | 0.11 | 0.00 | 0.00 | 0.01 | 0.17 |
| TAOK1 | ENSG00000160551 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.28 | 0.01 | 0.05 | 0.00 | 0.00 | 0.05 | 0.07 | 0.01 | 0.07 | 0.04 | 0.04 | 0.02 | 0.15 | 0.04 | 0.13 | 0.01 | 0.09 | 0.01 | 0.06 | 0.00 | 0.04 | 0.01 | 0.04 | 0.00 | 0.06 | 0.02 | 0.05 | 0.05 | 0.00 | 0.15 | 0.00 | 0.00 | 0.34 | 0.04 | 0.11 | 0.11 | 0.02 | 0.03 | 0.11 | 0.03 | 0.19 | 0.09 | 0.02 | 0.19 | 0.00 | 0.02 | 0.00 | 0.03 | 0.04 | 0.00 | 0.00 | 0.02 | 0.01 | 0.03 | 0.00 | 0.03 | 0.03 | 0.04 |
|
Showing page 234 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.