Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 225 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| SLC6A11 | ENSG00000132164 | 0.00 | 0.18 | 0.00 | 0.01 | 0.07 | 0.00 | 0.01 | 0.06 | 0.47 | 0.03 | 0.00 | 0.03 | 0.03 | 0.06 | 0.04 | 0.04 | 0.02 | 0.04 | 0.01 | 0.02 | 0.03 | 0.05 | 0.07 | 0.06 | 0.00 | 0.04 | 0.03 | 0.06 | 0.01 | 0.02 | 0.08 | 0.01 | 0.00 | 0.18 | 0.07 | 0.01 | 0.00 | 0.04 | 0.00 | 0.00 | 0.12 | 0.03 | 0.14 | 0.22 | 0.04 | 0.01 | 0.05 | 0.03 | 0.05 | 0.14 | 0.24 | 0.03 | 0.04 | 0.05 | 0.00 | 0.00 | 0.00 | 0.05 | 0.03 | 0.01 | 0.02 | 0.02 | 0.00 | 0.00 | 0.02 | 0.05 |
| BAX | ENSG00000087088 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.04 | 0.08 | 0.04 | 0.00 | 0.02 | 0.00 | 0.06 | 0.01 | 0.08 | 0.04 | 0.10 | 0.02 | 0.02 | 0.06 | 0.05 | 0.07 | 0.03 | 0.01 | 0.03 | 0.01 | 0.03 | 0.03 | 0.05 | 0.05 | 0.03 | 0.00 | 0.07 | 0.17 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.08 | 0.05 | 0.05 | 0.33 | 0.05 | 0.07 | 0.03 | 0.06 | 0.25 | 0.19 | 0.04 | 0.18 | 0.00 | 0.04 | 0.01 | 0.01 | 0.07 | 0.05 | 0.00 | 0.14 | 0.01 | 0.14 | 0.00 | 0.00 | 0.02 | 0.02 |
| HPSE2 | ENSG00000172987 | 0.00 | 0.01 | 0.00 | 0.02 | 0.03 | 0.00 | 0.02 | 0.11 | 0.01 | 0.10 | 0.00 | 0.02 | 0.00 | 0.19 | 0.01 | 0.04 | 0.02 | 0.09 | 0.01 | 0.06 | 0.02 | 0.09 | 0.01 | 0.09 | 0.01 | 0.10 | 0.00 | 0.06 | 0.01 | 0.03 | 0.03 | 0.06 | 0.16 | 0.18 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.01 | 0.02 | 0.08 | 0.07 | 0.34 | 0.01 | 0.07 | 0.02 | 0.09 | 0.03 | 0.09 | 0.02 | 0.05 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.07 | 0.00 | 0.04 | 0.01 | 0.05 | 0.00 | 0.00 | 0.02 | 0.04 |
| NPR2 | ENSG00000159899 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.12 | 0.03 | 0.00 | 0.00 | 0.01 | 0.09 | 0.06 | 0.03 | 0.39 | 0.04 | 0.29 | 0.04 | 0.27 | 0.03 | 0.18 | 0.02 | 0.02 | 0.00 | 0.01 | 0.00 | 0.19 | 0.00 | 0.03 | 0.02 | 0.19 | 0.01 | 0.14 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.07 | 0.02 | 0.12 | 0.06 | 0.02 | 0.01 | 0.05 | 0.01 | 0.02 | 0.13 | 0.13 | 0.05 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.05 | 0.06 | 0.00 | 0.03 | 0.09 | 0.05 |
| NPNT | ENSG00000168743 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.04 | 0.04 | 0.06 | 0.00 | 0.00 | 0.00 | 0.06 | 0.02 | 0.04 | 0.03 | 0.05 | 0.01 | 0.02 | 0.02 | 0.06 | 0.02 | 0.06 | 0.01 | 0.02 | 0.00 | 0.07 | 0.00 | 0.01 | 0.01 | 0.13 | 0.00 | 0.11 | 0.04 | 0.04 | 0.04 | 0.01 | 0.00 | 0.00 | 0.04 | 0.06 | 0.03 | 0.29 | 0.01 | 0.02 | 0.01 | 0.05 | 0.00 | 0.11 | 0.03 | 0.07 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.03 | 0.00 | 0.02 | 0.00 | 0.00 | 0.02 | 0.05 |
| SLC16A13 | ENSG00000174327 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.20 | 0.04 | 0.03 | 0.00 | 0.02 | 0.00 | 0.02 | 0.01 | 0.05 | 0.01 | 0.02 | 0.01 | 0.03 | 0.03 | 0.03 | 0.01 | 0.02 | 0.00 | 0.02 | 0.00 | 0.03 | 0.02 | 0.03 | 0.00 | 0.15 | 0.03 | 0.08 | 0.02 | 0.08 | 0.00 | 0.03 | 0.00 | 0.00 | 0.01 | 0.08 | 0.10 | 0.04 | 0.01 | 0.03 | 0.04 | 0.03 | 0.06 | 0.24 | 0.06 | 0.35 | 0.00 | 0.02 | 0.01 | 0.01 | 0.00 | 0.06 | 0.00 | 0.01 | 0.00 | 0.07 | 0.00 | 0.00 | 0.02 | 0.04 |
| AMICA1 | ENSG00000160593 | 0.02 | 0.01 | 0.00 | 0.06 | 0.02 | 0.02 | 0.03 | 0.08 | 0.04 | 0.11 | 0.00 | 0.00 | 0.07 | 0.06 | 0.05 | 0.07 | 0.05 | 0.09 | 0.05 | 0.16 | 0.04 | 0.12 | 0.07 | 0.07 | 0.01 | 0.01 | 0.03 | 0.03 | 0.01 | 0.02 | 0.02 | 0.09 | 0.00 | 0.17 | 0.03 | 0.05 | 0.00 | 0.06 | 0.00 | 0.00 | 0.03 | 0.23 | 0.14 | 0.14 | 0.05 | 0.30 | 0.05 | 0.05 | 0.15 | 0.16 | 0.04 | 0.21 | 0.00 | 0.15 | 0.02 | 0.00 | 0.14 | 0.01 | 0.07 | 0.01 | 0.01 | 0.01 | 0.00 | 0.07 | 0.01 | 0.26 |
| TTBK2 | ENSG00000128881 | 0.00 | 0.01 | 0.00 | 0.02 | 0.14 | 0.00 | 0.01 | 0.06 | 0.02 | 0.07 | 0.00 | 0.00 | 0.02 | 0.33 | 0.00 | 0.09 | 0.01 | 0.09 | 0.02 | 0.04 | 0.03 | 0.05 | 0.01 | 0.08 | 0.01 | 0.10 | 0.00 | 0.06 | 0.00 | 0.04 | 0.00 | 0.03 | 0.00 | 0.07 | 0.02 | 0.09 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.11 | 0.04 | 0.37 | 0.00 | 0.09 | 0.01 | 0.08 | 0.05 | 0.44 | 0.06 | 0.08 | 0.01 | 0.03 | 0.00 | 0.00 | 0.02 | 0.15 | 0.00 | 0.03 | 0.01 | 0.12 | 0.00 | 0.00 | 0.01 | 0.17 |
| SLC39A11 | ENSG00000133195 | 0.02 | 0.00 | 0.05 | 0.00 | 0.02 | 0.00 | 0.03 | 0.03 | 0.23 | 0.01 | 0.02 | 0.02 | 0.09 | 0.02 | 0.17 | 0.01 | 0.23 | 0.02 | 0.09 | 0.04 | 0.19 | 0.11 | 0.15 | 0.04 | 0.03 | 0.02 | 0.08 | 0.04 | 0.07 | 0.10 | 0.23 | 0.02 | 0.08 | 0.01 | 0.07 | 0.04 | 0.02 | 0.01 | 0.00 | 0.00 | 0.40 | 0.03 | 0.29 | 0.03 | 0.18 | 0.04 | 0.12 | 0.01 | 0.32 | 0.03 | 0.25 | 0.04 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.01 | 0.04 | 0.02 | 0.14 | 0.01 | 0.24 | 0.01 |
| ALOX15B | ENSG00000179593 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.22 | 0.02 | 0.03 | 0.00 | 0.01 | 0.00 | 0.03 | 0.01 | 0.05 | 0.01 | 0.02 | 0.01 | 0.03 | 0.03 | 0.04 | 0.01 | 0.02 | 0.00 | 0.03 | 0.00 | 0.02 | 0.01 | 0.02 | 0.00 | 0.16 | 0.02 | 0.03 | 0.01 | 0.05 | 0.01 | 0.03 | 0.00 | 0.00 | 0.01 | 0.06 | 0.08 | 0.06 | 0.00 | 0.04 | 0.03 | 0.04 | 0.06 | 0.15 | 0.19 | 0.29 | 0.00 | 0.02 | 0.02 | 0.01 | 0.00 | 0.10 | 0.01 | 0.00 | 0.00 | 0.06 | 0.00 | 0.00 | 0.00 | 0.04 |
| FMO3 | ENSG00000007933 | 0.03 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.42 | 0.01 | 0.02 | 0.02 | 0.10 | 0.03 | 0.12 | 0.01 | 0.23 | 0.01 | 0.04 | 0.00 | 0.20 | 0.01 | 0.11 | 0.01 | 0.03 | 0.00 | 0.12 | 0.00 | 0.05 | 0.00 | 0.23 | 0.01 | 0.22 | 0.01 | 0.00 | 0.04 | 0.04 | 0.00 | 0.00 | 0.00 | 0.18 | 0.02 | 0.32 | 0.02 | 0.15 | 0.00 | 0.10 | 0.00 | 0.29 | 0.00 | 0.53 | 0.02 | 0.10 | 0.00 | 0.00 | 0.00 | 0.30 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.15 | 0.01 |
| APAF1 | ENSG00000120868 | 0.01 | 0.01 | 0.01 | 0.01 | 0.06 | 0.04 | 0.05 | 0.02 | 0.05 | 0.05 | 0.00 | 0.00 | 0.02 | 0.06 | 0.02 | 0.06 | 0.02 | 0.05 | 0.02 | 0.05 | 0.03 | 0.12 | 0.03 | 0.05 | 0.01 | 0.02 | 0.01 | 0.03 | 0.00 | 0.07 | 0.03 | 0.06 | 0.00 | 0.20 | 0.00 | 0.01 | 0.00 | 0.05 | 0.00 | 0.00 | 0.04 | 0.10 | 0.09 | 0.31 | 0.01 | 0.03 | 0.04 | 0.10 | 0.01 | 0.44 | 0.13 | 0.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.08 | 0.01 | 0.02 | 0.01 | 0.02 | 0.00 | 0.00 | 0.01 | 0.08 |
| SLC2A10 | ENSG00000197496 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.14 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.04 | 0.09 | 0.01 | 0.00 | 0.01 | 0.05 | 0.00 | 0.16 | 0.00 | 0.14 | 0.00 | 0.15 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.15 | 0.03 | 0.27 | 0.04 | 0.02 | 0.04 | 0.11 | 0.01 | 0.45 | 0.00 | 0.10 | 0.03 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.07 | 0.00 |
| CYP2C8 | ENSG00000138115 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.11 | 0.02 | 0.10 | 0.00 | 0.02 | 0.00 | 0.16 | 0.01 | 0.03 | 0.02 | 0.07 | 0.01 | 0.06 | 0.02 | 0.08 | 0.01 | 0.10 | 0.00 | 0.09 | 0.00 | 0.06 | 0.01 | 0.03 | 0.02 | 0.06 | 0.16 | 0.07 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.02 | 0.08 | 0.08 | 0.30 | 0.00 | 0.07 | 0.02 | 0.10 | 0.03 | 0.09 | 0.02 | 0.05 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.07 | 0.02 | 0.03 | 0.00 | 0.05 | 0.00 | 0.00 | 0.01 | 0.04 |
| CNTN2 | ENSG00000184144 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.06 | 0.05 | 0.02 | 0.00 | 0.12 | 0.00 | 0.15 | 0.00 | 0.11 | 0.01 | 0.05 | 0.00 | 0.15 | 0.06 | 0.05 | 0.01 | 0.04 | 0.00 | 0.13 | 0.01 | 0.00 | 0.00 | 0.21 | 0.01 | 0.18 | 0.02 | 0.01 | 0.02 | 0.03 | 0.00 | 0.00 | 0.00 | 0.28 | 0.01 | 0.29 | 0.08 | 0.06 | 0.00 | 0.12 | 0.01 | 0.12 | 0.00 | 0.12 | 0.15 | 0.05 | 0.02 | 0.01 | 0.00 | 0.26 | 0.02 | 0.08 | 0.01 | 0.41 | 0.00 | 0.09 | 0.00 | 0.21 | 0.01 |
| CPT1A | ENSG00000110090 | 0.01 | 0.00 | 0.03 | 0.01 | 0.08 | 0.02 | 0.09 | 0.01 | 0.39 | 0.02 | 0.00 | 0.00 | 0.08 | 0.00 | 0.18 | 0.01 | 0.48 | 0.02 | 0.95 | 0.01 | 1.35 | 0.02 | 0.22 | 0.03 | 0.01 | 0.01 | 0.07 | 0.02 | 0.05 | 0.02 | 0.30 | 0.01 | 0.49 | 0.05 | 0.00 | 0.01 | 0.03 | 0.00 | 0.00 | 0.00 | 0.69 | 0.04 | 0.34 | 0.04 | 0.22 | 0.01 | 0.12 | 0.02 | 0.18 | 0.10 | 0.13 | 0.06 | 0.00 | 0.05 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.01 | 0.04 | 0.00 | 0.00 | 0.31 | 0.02 |
| SLC9A5 | ENSG00000135740 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.06 | 0.00 | 0.07 | 0.14 | 0.02 | 0.00 | 0.00 | 0.03 | 0.07 | 0.04 | 0.03 | 0.05 | 0.01 | 0.04 | 0.01 | 0.12 | 0.01 | 0.04 | 0.02 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.00 | 0.02 | 0.04 | 0.05 | 0.01 | 0.23 | 0.02 | 0.01 | 0.02 | 0.00 | 0.01 | 0.02 | 0.05 | 0.04 | 0.32 | 0.03 | 0.02 | 0.03 | 0.08 | 0.09 | 0.14 | 0.02 | 0.04 | 0.15 | 0.01 | 0.00 | 0.05 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.02 | 0.00 | 0.03 | 0.04 | 0.00 |
| CAMK2G | ENSG00000148660 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.00 | 0.01 | 0.05 | 0.11 | 0.03 | 0.00 | 0.00 | 0.01 | 0.00 | 0.03 | 0.02 | 0.07 | 0.03 | 0.04 | 0.03 | 0.07 | 0.05 | 0.17 | 0.04 | 0.04 | 0.03 | 0.09 | 0.03 | 0.02 | 0.00 | 0.06 | 0.03 | 0.25 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.12 | 0.03 | 0.24 | 0.11 | 0.01 | 0.02 | 0.14 | 0.03 | 0.23 | 0.08 | 0.06 | 0.10 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.03 | 0.00 | 0.00 | 0.01 | 0.02 |
| GPR141 | ENSG00000187037 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.02 | 0.09 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.05 | 0.03 | 0.03 | 0.01 | 0.09 | 0.02 | 0.02 | 0.01 | 0.03 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.02 | 0.10 | 0.09 | 0.01 | 0.00 | 0.03 | 0.02 | 0.05 | 0.00 | 0.12 | 0.04 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.02 | 0.01 | 0.00 | 0.06 | 0.01 | 0.00 | 0.00 | 0.04 | 0.03 |
| PVRL1 | ENSG00000110400 | 0.01 | 0.01 | 0.00 | 0.05 | 0.02 | 0.02 | 0.01 | 0.08 | 0.03 | 0.12 | 0.00 | 0.00 | 0.11 | 0.04 | 0.05 | 0.08 | 0.05 | 0.09 | 0.04 | 0.16 | 0.04 | 0.12 | 0.07 | 0.07 | 0.00 | 0.02 | 0.00 | 0.03 | 0.01 | 0.02 | 0.01 | 0.09 | 0.00 | 0.17 | 0.00 | 0.09 | 0.00 | 0.06 | 0.00 | 0.00 | 0.02 | 0.22 | 0.17 | 0.15 | 0.04 | 0.31 | 0.04 | 0.06 | 0.05 | 0.19 | 0.05 | 0.25 | 0.00 | 0.17 | 0.03 | 0.01 | 0.08 | 0.05 | 0.07 | 0.01 | 0.02 | 0.01 | 0.01 | 0.07 | 0.00 | 0.28 |
|
Showing page 225 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.